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Taking trazodone with other medicines and herbal supplements

Cautions with other medicines

Many medicines can affect the way trazodone works, and trazodone can do the same to other medicines. Both can increase the chances of you having side effects.

Tell your doctor if you're taking any of these medicines before you start trazodone:

  • tranylcypromine, phenelzine or isocarboxazid (for depression), or selegiline (for Parkinson's disease) if you have taken any of these medicines within the last 2 weeks
  • antidepressants, such as amitriptyline or fluoxetine
  • antifungal medicines, such as ketoconazole or itraconazole
  • epilepsy medicines, such as carbamazepine or phenytoin
  • medicines for high blood pressure, such as clonidine
  • sleeping pills, tranquilisers or other sedatives
  • digoxin, a heart medicine
  • erythromycin, an antibiotic
  • levodopa, used to treat Parkinson's disease
  • ritonavir, used to treat HIV infections
  • warfarin, used to prevent blood clots

Mixing trazodone with herbal remedies and supplements

Do not take St John's wort, the herbal remedy for depression, while you're being treated with trazodone as this will increase your risk of side effects.

There's not enough information to say that other herbal remedies and supplements are safe to take with trazodone. They're not tested in the same way as pharmacy and prescription medicines. They're generally not tested for the effect they have on other medicines.

Important: Medicine safety

Tell your doctor or pharmacist if you're taking any other medicines, including herbal remedies, vitamins or supplements.

Page last reviewed: 9 March 2022
Next review due: 9 March 2025