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Taking pantoprazole with other medicines and herbal supplements - Brand name: Pantoloc Control

Cautions with other medicines

Some medicines and pantoprazole can affect each other and make you more likely to have side effects or stop one of the medicines working as well.

Tell your doctor before starting to take pantoprazole if you're taking any other medicines, including:

  • antifungal medicines such as itraconazole, posaconazole or voriconazole
  • methotrexate, a medicine used to treat cancer, psoriasis and rheumatoid arthritis
  • HIV medicines
  • rifampicin, an antibiotic
  • medicines that help to prevent blood clots, such as warfarin

These are not all the medicines that may cause problems if you take them with pantoprazole. For a full list, see the leaflet inside your medicine packet.

Mixing pantoprazole with herbal remedies and supplements

Do not take St John's wort, the herbal remedy for depression, while you're taking pantoprazole. St John's wort may stop pantoprazole working as well as it should.

There's not enough information to say that other complementary medicines and herbal remedies are safe to take with pantoprazole. They're not tested in the same way as pharmacy and prescription medicines. They're generally not tested for the effect they have on other medicines.

Important: Medicine safety

Tell your doctor or pharmacist if you're taking any other medicines, including herbal remedies, vitamins or supplements.

Page last reviewed: 31 July 2025
Next review due: 31 July 2028