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Other medicines for menopause symptoms

Hormone replacement therapy (HRT) is the most common treatment for menopause symptoms, but it's not suitable for everyone. If you've had breast cancer, for example, you'll usually be advised not to take it.

If you cannot take HRT or do not want to, you may still be able to take other medicines that can help your menopause symptoms.

Ask a GP for advice.

Antidepressants

Antidepressants can help with mood symptoms if you've been diagnosed with depression or anxiety.

There are 2 types of antidepressants – selective serotonin reuptake inhibitors (SSRIs) and serotonin-noradrenaline reuptake inhibitors (SNRIs).

Your doctor will discuss the possible benefits and risks with you.

Side effects of SSRIs and SNRIs can include feeling agitated, shaky or anxious, feeling sick, feeling dizzy and a reduced sex drive.

Any side effects will usually improve over time, but see a GP if they do not.

Clonidine

Clonidine is a prescription medicine that can help reduce hot flushes and night sweats caused by menopause. You take it as tablets 2 times a day.

It does not affect hormone levels, so unlike HRT it does not increase the risk of breast cancer.

Clonidine can also cause side effects such as dry mouth, drowsiness, depression and constipation.

It may take 2 to 4 weeks to notice the effects of clonidine. Speak to a GP if your symptoms do not improve or you have problems with side effects.

Page last reviewed: 7 February 2023
Next review due: 7 February 2026