Felodipine

1. About felodipine

Felodipine is a medicine used to treat high blood pressure.

If you have high blood pressure, taking felodipine helps to prevent future heart disease, heart attacks and strokes.

Felodipine is also used to prevent angina (chest pain caused by heart disease).

This medicine is only available on prescription. It comes as tablets.

2. Key facts

  • Felodipine lowers your blood pressure and makes it easier for your heart to pump blood around your body.
  • It's usual to take felodipine once a day in the morning.
  • If you get severe vomiting or diarrhoea from a stomach bug or illness, tell your doctor. You may need to stop taking felodipine for a while until you feel better.
  • Do not eat grapefruit or drink grapefruit juice while you're taking felodipine. Grapefruit can make side effects worse.
  • Felodipine is also called by various brand names, including Plendil, Cardioplen XL, Folpik XL, Vascalpha and Neofel XL.

3. Who can and can't take felodipine

Adults aged 18 and over can take felodipine.

Felodipine isn't suitable for some people.

To make sure felodipine is safe for you, tell your doctor if you:

  • have had an allergic reaction to felodipine or any other medicine in the past
  • are trying to get pregnant, are already pregnant or if you are breastfeeding
  • have heart failure or heart disease or you've recently had a heart attack
  • have new chest pain or chest pain that lasts longer or is more severe than usual
  • have liver problems

4. How and when to take

Take felodipine as your doctor has told you, and follow the directions on the label. If you're not sure, check with your doctor or pharmacist.

Felodipine comes as 'prolonged release' tablets (sometimes called 'modified release'). This means that the tablets release felodipine slowly and evenly throughout the day.

How much will I take?

Your dose of felodipine depends on why you need the medicine. To decide the correct dose for you, your doctor will check your blood pressure.

The usual starting dose of felodipine for high blood pressure and angina is 5mg once a day.

Elderly patients usually start on a lower dose of 2.5mg once a day.

How to take it

It's usual to take felodipine once a day in the morning. It's best to take it on an empty stomach or after a light meal or snack that isn't too fatty or starchy.

Swallow the tablets whole with a glass of water. Do not break, crush or chew them. Talk to your pharmacist or doctor if you have problems swallowing them.

Do not eat or drink grapefruit or grapefruit juice while you're taking this medicine. Grapefruit juice can make side effects worse.

Will my dose go up or down?

If the starting dose isn't working well enough, your doctor may increase it to 10mg a day.

If you have side effects or your blood pressure goes too low, your doctor may lower your dose to 2.5mg a day.

Important

Take felodipine even if you feel well, as you will still be getting the benefits of the medicine.

What if I forget to take it?

If you forget a dose of felodipine, just take your next dose at the usual time. Do not take a double dose to make up for a forgotten one.

If you forget doses often, it may help to set an alarm to remind you. You could also ask your pharmacist for advice on other ways to help you remember to take your medicine.

What if I take too much?

An overdose of felodipine can cause dizziness and make you feel sick and sleepy.

The amount of felodipine that can lead to an overdose varies from person to person.

Call your doctor or go to A&E straight away if you take too much felodipine by accident

If you need to go to a hospital accident and emergency (A&E) department, do not drive yourself - get someone else to drive you or call for an ambulance.

Take the felodipine box, or the leaflet inside the packet, plus any remaining medicine with you.

5. Side effects

Like all medicines, felodipine can cause side effects, although not everyone gets them. Side effects often improve as your body gets used to the medicine.

Common side effects

These common side effects happen in more than 1 in 100 people. They are usually mild and short-lived.

Talk to your doctor or pharmacist if the side effects bother you or last for more than a few days:

  • headaches
  • dizziness
  • flushing (feeling hot)
  • a pounding heartbeat
  • swollen ankles

Serious side effects

Serious side effects are rare and happen in less than 1 in 1,000 people. Stop taking the medicine and contact a doctor straight away if you get:

  • chest pain that is new or worse - this side effect needs to be checked out as chest pain is a possible symptom of a heart attack

Serious allergic reaction

In rare cases, it's possible to have a serious allergic reaction (anaphylaxis) to felodipine.

Contact a doctor straight away if:

  • you get a skin rash that may include itchy, red, swollen, blistered or peeling skin
  • you're wheezing
  • you get tightness in the chest or throat
  • you have trouble breathing or talking
  • your mouth, face, lips, tongue or throat start swelling

These are warning signs of a serious allergic reaction. A serious allergic reaction is an emergency.

These are not all the side effects of felodipine. For a full list see the leaflet inside your medicines packet.

Information:

You can report any suspected side effect to the UK safety scheme.

6. How to cope with side effects

What to do about:

  • headaches - make sure you rest and drink plenty of fluids. Don't drink too much alcohol. Ask your pharmacist to recommend a painkiller. Headaches should usually go away after the first week of taking felodipine. Talk to your doctor if they last longer than a week or are severe.
  • feeling dizzy - if felodipine makes you feel dizzy, stop what you're doing and sit or lie down until you feel better
  • flushing - try cutting down on coffee, tea and alcohol. It might help to keep the room cool and use a fan. You could also spray your face with cool water or sip cold or iced drinks. The flushing should go away after a few days. If it doesn't go away, or if it's causing you problems, contact your doctor.
  • swollen ankles - raise your legs while you're sitting down

7. Pregnancy and breastfeeding

Felodipine is not recommended in pregnancy or when breastfeeding.

If you're trying to get pregnant or you're already pregnant, talk to your doctor about the benefits and possible harms of taking felodipine. There are usually other medicines that are safer for you.

Felodipine and breastfeeding

Small amounts of felodipine may get into breast milk, but it's not known if this is harmful to the baby. Talk to your doctor as other medicines might be better while you're breastfeeding.

Tell your doctor if you're:

  • trying to get pregnant
  • pregnant
  • breastfeeding

8. Cautions with other medicines

If you take other medicines that lower blood pressure with felodipine, the combination can sometimes lower your blood pressure too much. This may make you feel dizzy or faint. If this keeps happening to you, tell your doctor as your dose may need to be changed.

Some medicines can interfere with the way felodipine works.

Tell your doctor if you're taking any of these medicines before starting felodipine:

  • anti-epilepsy medicines: carbamazepine, phenytoin, phenobarbital (phenobarbitone) or primidone
  • antibiotics: clarithromycin, erythromycin or rifampicin
  • the antifungal itraconazole
  • medicines for HIV or HCV (hepatitis C virus)
  • medicines to reduce immune reactions such as ciclosporin or tacrolimus

Mixing felodipine with herbal remedies or supplements

To be safe, speak to your pharmacist or doctor before taking any herbal or alternative remedies with felodipine.

St John's wort, a herbal medicine taken for depression, is thought to interfere with the way felodipine works. Talk to your doctor if you're thinking about taking St John's wort.

Important

Tell your doctor or pharmacist if you're taking any other medicines, including herbal remedies, vitamins or supplements.

9. Common questions

How does felodipine work?

Felodipine is a type of medicine called a calcium channel blocker.

Like other calcium channel blockers, it relaxes and widens blood vessels. It does this by blocking calcium going into muscles in the heart and blood vessels. Muscles need calcium to contract, so when you block the calcium, it makes the muscle cells relax. This lowers your blood pressure and makes it easier for your heart to pump blood around your body.

In angina, felodipine works by improving the blood supply to your heart. Angina is chest pain that comes on when not enough blood gets to the muscles of the heart. It usually happens because the arteries to the heart have become hardened and narrowed.

Felodipine widens the arteries so more oxygen gets to the heart which prevents chest pain.

How long does felodipine take to work?

Felodipine starts to work on the day you start taking it, but it may take a couple of weeks for full effect.

If you're taking felodipine for high blood pressure, you may not have any symptoms. In this case, you may not feel any different when you take it. This doesn't mean that the medicine isn't working and it's important to keep taking it. Your doctor will check to see how well it is working.

If you're taking felodipine for angina, it will probably take a couple of weeks before you feel better. Until then, you'll still get chest pain. Make sure you have your medicine (spray or tablets) for treating angina attacks with you at all times, and use it if you need to. Keep taking felodipine every day and you should have fewer attacks within a couple of weeks. Talk to your doctor if your chest pain (angina) does not get any better after a couple of weeks. If it gets worse (happens more often or is more severe) tell your doctor immediately.

How long will I take it for?

Usually, treatment with felodipine is long term, even for the rest of your life.

Is felodipine safe to take for a long time?

Felodipine is generally safe to take for a long time. In fact, it works best when you take it for a long time.

Can I come off felodipine now my blood pressure is lower?

Even if felodipine lowers your blood pressure successfully, it's best to carry on taking it. If you stop taking felodipine, your blood pressure could rise back up again.

If you are taking felodipine for angina, stopping it will increase your chances of having more angina attacks.

If you need blood pressure-lowering medicines, you'll probably need to take them for the rest of your life.

Remember, by keeping your blood pressure low, you're protecting yourself against having a heart attack or stroke in the future.

What will happen if I stop taking it?

Talk to your doctor if you want to stop taking felodipine.

Stopping felodipine may cause your blood pressure to rise - and this may increase your risk of heart attack and stroke.

If you are taking it for angina, stopping it will make it more likely you will have more angina attacks.

If you're bothered by side effects, your doctor may be able to prescribe you a different medicine.

Can I drink alcohol with it?

Yes, you can drink alcohol with felodipine. However, drinking alcohol can increase the blood pressure-lowering effect of felodipine, which can make you feel dizzy or light-headed. If this happens to you, it's best to stop drinking alcohol while you're taking it.

Are there similar medicines to felodipine?

For high blood pressure

There are several other calcium channel blockers which lower blood pressure in the same way as felodipine. They include amlodipine, nifedipine, lacidipine and lercanidipine.

There are also lots of other types of medicines to lower your blood pressure. They work in a different way to calcium channel blockers and include:

  • ACE inhibitors - for example ramipril and lisinopril
  • angiotensin receptor blockers - for example candesartan
  • beta-blockers - for example bisoprolol
  • diuretics (water tablets) - for example [bendroflumethiazide]https://beta.nhs.uk/medicines/bendroflumethiazide/)

If you can't take felodipine or other calcium channel blockers because of side effects, you may be able to switch to another medicine. Your doctor will advise which one is best for you depending on your age, ethnicity and medical history.

For angina

There are other calcium channel blockers, such as diltiazem and verapamil, which are used for angina. There are also other medicines for angina which work in a different way. They include:

  • beta-blockers - for example bisoprolol
  • nitrates - for example isosorbide dinitrate
Is felodipine addictive?

No, there's no evidence that felodipine is addictive.

Will it affect my contraception?

Felodipine won't affect any type of contraception.

However, some types of hormonal methods of contraception, like the combined contraceptive pill and contraceptive patch, aren't usually recommended for women taking felodipine and other medicines for high blood pressure. This is because some hormonal contraceptives can raise your blood pressure and stop felodipine working properly.

Talk to your doctor if you're taking combined hormonal contraceptives.

Will it affect my fertility?

It's unlikely that felodipine affects fertility in men or women.

However, there is not enough information available to be able to say for certain whether or not felodipine has any effect on fertility. If you are trying for a baby, or are having problems conceiving while on felodipine then speak to your doctor.

Is there any food or drink I need to avoid?

Do not eat grapefruit or drink grapefruit juice. Grapefruit can make the side effects of felodipine worse.

Otherwise, you can eat and drink normally while taking felodipine.

Can I drive or ride a bike?

Felodipine can make some people feel dizzy. If this happens to you, do nt drive a car, ride a bike, or use tools or machinery until you feel better.

Can lifestyle changes help?

You can boost the health of your heart by making some key lifestyle changes. These will also help if you have high blood pressure or angina.

  • Stop smoking - smoking increases your heart rate and blood pressure. Quitting smoking brings down your blood pressure and relieves heart failure symptoms. Try and avoid secondhand smoke.
  • Drink alcohol sensible - drinking too much alcohol raises blood pressure over time. It makes heart failure worse too. Men and women shouldn't drink more than 14 units of alcohol a week.
  • Be more active - regular exercise lowers blood pressure by keeping your heart and blood vessels in good condition. It doesn’t need to be too energetic - walking every day is enough.
  • Eat healthily - aim to eat a diet that includes plenty of fruit and veg, wholegrains, fat-free or low-fat dairy products and lean proteins. It's a good idea to cut down on salt too. Eating too much salt is the biggest cause of high blood pressure
  • the more salt you eat, the higher your blood pressure will be. Aim for no more than 6g of salt a day.
  • Manage stress - when you're anxious or upset, your heart beats faster, you breathe more heavily and your blood pressure often goes up. This can make heart failure worse too. Find ways to reduce stress in your life. To give your heart a rest, try napping or putting your feet up when possible. Spend time with friends and family to be social and help avoid stress.
  • Vaccinations - if you have heart failure, it's recommended that you have a flu jab every year and a pneumonia vaccination every 5 years. Ask your doctor about these vaccinations. You can have them free on the NHS.

Page last reviewed: 09/08/2017
Next review due: 09/08/2020