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Taking doxycycline with other medicines and herbal supplements

Cautions with other medicines

There are some medicines that do not mix well with doxycycline. Before taking it, tell your doctor if you're already taking any of these medicines:

  • indigestion remedies (antacids)
  • stomach ulcer medicines that contain bismuth such as Pepto-Bismol
  • other antibiotics, such as rifampicin
  • acne medicines containing vitamin A, such as isotretinoin
  • warfarin, a medicine to help prevent blood clots
  • medicines for epilepsy, such as phenytoin or carbamazepine
  • ciclosporin, a medicine that calms down your immune system

A typhoid vaccine given by mouth (orally) may not work properly if you're taking doxycycline. It is OK to have the typhoid vaccine that comes as an injection when taking antibiotics, as it is not a live vaccine.

Mixing doxycycline with herbal remedies and supplements

Tell your doctor if you're taking any supplements including:

  • anything which contains aluminium, bismuth, calcium, magnesium or zinc
  • iron supplements

Important: Medicine safety

Tell your doctor or pharmacist if you're taking any other medicines, including herbal remedies, vitamins or supplements.

Page last reviewed: 19 January 2022
Next review due: 19 January 2025