1. About diclofenac
Diclofenac is a medicine that reduces swelling (inflammation) and pain.
It's used to treat aches and pains, as well as problems with joints, muscles and bones. These include:
- rheumatoid arthritis and osteoarthritis
- sprains and strains in muscles and ligaments
- back pain
- ankylosing spondylitis – this causes inflammation of the spine and other parts of the body
Diclofenac comes as tablets and capsules, including slow-release tablets and capsules, and suppositories. These are available on prescription only.
Diclofenac gel and plasters for joint pain are available to buy from pharmacies.
It can also be given as an injection or as eyedrops. These are usually only given in hospital.
A high strength diclofenac gel (containing 3% diclofenac) is used to treat actinic keratoses (dry, scaly patches of skin caused by sun damage). This treatment is usually started after assessment by a dermatologist and is not covered here.
2. Key facts
- It's best to take the lowest dose of diclofenac for the shortest time to control your symptoms.
- Take diclofenac tablets or capsules with a meal or snack, or just after eating.
- Common side effects are stomach pain, feeling or being sick and rashes.
- Diclofenac gel and plasters can be used twice a day to target pain in a particular area of your body.
3. Who can and cannot take diclofenac
Most adults can take diclofenac.
Children may be prescribed diclofenac to treat joint problems. Diclofenac tablets, capsules and suppositories are suitable for children aged 6 months and above.
Diclofenac gel is suitable for children aged 14 and above. Diclofenac plasters and patches are suitable for young people aged 16 and above.
Diclofenac is not suitable for some people. To make sure it's safe for you, tell your doctor or pharmacist if you:
- have ever had an allergic reaction to diclofenac or any other medicines
- have an allergy to aspirin or other non-steroidal anti-inflammatory medicines (NSAIDs) such as ibuprofen or naproxen
- have ever had side effects from taking NSAIDs, such as wheezing or other signs of asthma, a runny nose, swelling of the skin (angioedema) or a rash
- have ever had stomach ulcers, bleeding in the stomach or intestines, or a hole in your stomach
- have high blood pressure (hypertension)
- have heart failure, severe liver disease or kidney disease
- have Crohn's disease or ulcerative colitis
- have lupus
- have a blood clotting disorder
- are pregnant, planning to get pregnant, or breastfeeding
4. How and when to take or use diclofenac
Always follow the advice of a pharmacist or doctor, and the instructions that come with your medicine.
Diclofenac tablets, capsules and suppositories
You'll usually take diclofenac tablets, capsules or suppositories 2 to 3 times a day.
The usual dose is 75mg to 150mg a day, depending on what your doctor prescribes for you. Follow your doctor's advice on how many tablets to take, and how many times a day.
If your doctor prescribes diclofenac for your child, they'll use your child's weight to work out the right dose for them.
If you have pain all the time, your doctor may recommend slow-release diclofenac tablets or capsules. You'll usually take these either once a day in the evening, or twice a day. If you're taking slow-release diclofenac twice a day, leave a gap of 10 to 12 hours between your doses.
How to take tablets and capsules
Swallow diclofenac tablets or capsules with a drink of milk. If you need to take them with water, take them after a meal or snack. Taking them with milk or food means they'll be less likely to upset or irritate your stomach.
Swallow them whole, do not crush, break or chew them.
How to use suppositories
Suppositories are medicine that you push gently into your anus (bottom).
- Go to the toilet beforehand if you need to.
- Wash your hands before and after using the medicine. Also clean around your anus with mild soap and water, rinse and pat dry.
- Unwrap the suppository.
- Gently push the suppository into your anus with the pointed end first. It needs to go in about 3 centimetres (1 inch).
- Sit or lie still for about 15 minutes. The suppository will melt inside your anus. This is normal.
You'll usually use the gel 2 to 4 times a day, depending on how strong it is. Check the packaging for more information or speak to your pharmacist.
If you're using the gel twice a day, use it once in the morning and once in the evening. If you're using it 3 or 4 times a day, wait at least 4 hours before putting on any more.
The amount of gel you need depends on the size of the area you want to treat. You'll usually use an amount about the size of a 1 penny or 2 pence piece (2 to 4 grams).
Important: Maximum dose for diclofenac gel
Do not use diclofenac gel more than 4 times in any 24-hour period.
How to use the gel
- Gently squeeze the tube, or press firmly and evenly on the nozzle of the dispenser, to get a small amount of gel.
- Put the gel on the painful or swollen area and slowly rub it in. It may feel cool on your skin. Wash your hands afterwards.
Diclofenac plasters and patches
Treat only 1 painful area at a time. Do not use more than 2 medicated plasters or patches in any 24-hour period.
How to use plasters and patches
- Stick a medicated plaster or patch over the painful area twice a day, once in the morning and once in the evening. Take the old patch off before you put the new one on.
- Apply gentle pressure with the palm of your hand until it's completely stuck to your skin.
- When you want to take the plaster or patch off, it helps to moisten it with some water first. Once you have taken it off, wash the affected skin and rub it gently in circular movements to remove any leftover glue.
What if I forget to take it?
If you forget to take diclofenac, take it as soon as you remember, unless it's nearly time for your next dose. In this case, skip the missed dose and take the next one at the usual time.
Never take a double dose to make up for a forgotten dose.
If you often forget doses, it may help to set an alarm to remind you. You could also ask your pharmacist for advice on other ways to help you remember your medicine.
What if I take too much?
Taking more than your prescribed dose of diclofenac tablets, capsules or suppositories can be dangerous. It can cause side effects such as:
- stomach ache
- feeling or being sick (vomiting)
- black poo or blood in your vomit – a sign of bleeding in your stomach
- ringing in your ears (tinnitus)
Urgent advice: Contact 111 for advice if:
- you take too many diclofenac tables, capsules or suppositories
Go to 111.nhs.uk or call 111
If you need advice for a child under the age of 5 years, call 111.
If you need to go to hospital, take the diclofenac packet or the leaflet inside it, plus any remaining medicine, with you.
What if I use too many plasters or patches or too much gel?
If you use too many plasters or patches or too much gel by mistake, it's unlikely to do you any harm. But if you use too much and get any side effects, tell your doctor straight away.
5. Taking diclofenac with other painkillers
Diclofenac, aspirin, ibuprofen and naproxen all belong to the same group of medicines called non-steroidal anti-inflammatory drugs (NSAIDs). Taking diclofenac together with other NSAIDs may increase your chances of getting side effects like a stomach ache.
NSAIDs are also used in medicines you can buy from pharmacies, such as cough and cold remedies.
Before taking any other medicines together with diclofenac, check the label to see if they contain ibuprofen, aspirin or other NSAIDs.
6. Side effects
Like all medicines, diclofenac can cause side effects, although not everyone gets them.
Common side effects
Common side effects of diclofenac tablets, capsules and suppositories happen in more than 1 in 100 people.
Talk to your doctor or pharmacist if these side effects bother you or do not go away:
- feeling sick (nausea)
- being sick (vomiting) or diarrhoea
- feeling dizzy or vertigo
- stomach ache, wind or loss of appetite
- mild rash
You're less likely to have side effects with diclofenac gel or plasters. This is because less medicine gets into your body. But you may still get the same side effects, especially if you use a lot on a large area of skin.
Using diclofenac gel or plasters can affect your skin. It can make your skin:
- more sensitive to sunlight than normal
- develop a rash where you applied the gel or plaster
- dry or irritated (eczema)
- itchy or inflamed (dermatitis)
Serious side effects
These serious side effects are rare and happen in less than 1 in 1,000 people.
Call your doctor straight away if:
- you have blood in your vomit or black poo – these could be signs of bleeding in your stomach or gut
- you have severe indigestion, heartburn or stomach pain, vomiting or diarrhoea – these can be signs of an ulcer or inflammation in your stomach or gut
- the whites of your eyes or your skin turn yellow, although this may be less obvious on brown or black skin – this can be a sign of liver problems
- you have a raised, itchy rash, or swollen or puffy skin – these can be signs of hives (urticaria) or oedema (swelling)
- you have breathlessness, tiredness and swollen legs or ankles – these can be signs of heart failure
Immediate action required: Call 999 or go to A&E if:
- you have chest pain, shortness of breath, feel weak or lightheaded, or have an overwhelming feeling of anxiety – these can be signs of a heart attack
- you have weakness on one side of your body, trouble speaking or thinking, loss of balance or blurred eyesight – these can be signs of a stroke
Serious allergic reaction
In rare cases, it's possible to have a serious allergic reaction (anaphylaxis) to diclofenac.
Immediate action required: Call 999 or go to A&E now if:
- you get a skin rash that may include itchy, red, swollen, blistered or peeling skin
- you're wheezing
- you get tightness in the chest or throat
- you have trouble breathing or talking
- your mouth, face, lips, tongue or throat start swelling
You could be having a serious allergic reaction and may need immediate treatment in hospital.
These are not all the side effects of diclofenac. For a full list, see the leaflet inside your medicine packet.
You can report any suspected side effect using the Yellow Card safety scheme.
7. How to cope with side effects of diclofenac
What to do about:
- feeling sick (nausea) – take diclofenac with or after a meal or snack. It may also help if you avoid rich or spicy food.
- being sick (vomiting) or diarrhoea – drink plenty of water or other fluids. If you're being sick, try small frequent sips of water. Speak to a pharmacist if you have signs of dehydration, such as peeing less than usual or having dark, strong-smelling pee. Speak to a doctor if being sick or diarrhoea lasts for longer than 3 days. Do not take any other medicines without speaking to a pharmacist or doctor.
- feeling dizzy or vertigo – if you feel dizzy or unsteady, stop what you're doing and sit or lie down until you feel better. Do not drive or cycle, or use tools or machinery, if you're feeling dizzy or lightheaded. As your body gets used to diclofenac, these side effects should wear off.
- headaches – make sure you rest and drink plenty of fluids. Do not drink too much alcohol. Ask your pharmacist to recommend an alternative painkiller. Headaches should usually go away after the first week of taking diclofenac. Talk to your doctor if they last longer than a week or are severe.
- stomach ache, wind or loss of appetite – try not to eat foods that cause wind (like peas, lentils, beans and onions). Eat smaller meals, eat and drink slowly, and exercise regularly.
- a mild rash and dry or irritated, itchy or inflamed skin – use an emollient cream or ointment to moisturise, soothe and hydrate the affected area. If it does not get better within a week or you're worried, speak to a pharmacist or doctor.
- skin being more sensitive to sunlight – stay out of bright sun and use a high factor sun cream (SPF 15 or above), even on cloudy days. Do not use a sunlamp or sunbeds.
8. Pregnancy and breastfeeding
Diclofenac and pregnancy
Diclofenac is not usually recommended in pregnancy.
This is because diclofenac may cause problems for your unborn baby. For example it can affect your baby's circulation and it can cause you to have too little amniotic fluid surrounding your baby in the womb.
Your doctor will only advise you to take diclofenac while you're pregnant if the benefits of taking the medicine clearly outweigh the risks.
There may be other treatments that are safer for you. Paracetamol is generally the best painkiller to take during pregnancy.
Diclofenac and breastfeeding
You can take diclofenac while breastfeeding. Only very small amounts get into breast milk which are unlikely to cause side effects in your baby. Many breastfeeding mothers have used it without any problems.
If you notice that your baby is not feeding as well as usual, or if you have any other concerns about your baby, talk to your midwife, health visitor, pharmacist or doctor as soon as possible.
Non-urgent advice: Tell your doctor if you're:
- trying to get pregnant
For more information about how this medicine can affect you and your baby, read this leaflet on diclofenac on the Best Use of Medicines in Pregnancy (BUMPs) website.
9. Cautions with other medicines
There are some medicines that affect the way diclofenac works. Tell your doctor if you're taking:
- other anti-inflammatory medicines, such as aspirin or ibuprofen
- antibiotics, such as ciprofloxacin, levofloxacin, moxifloxacin, nalidixic acid, norfloxacin or ofloxacin
- anticoagulants (sometimes called "blood thinners"), such as warfarin
- medicines for heart problems, such as digoxin, and medicines for high blood pressure
- medicines to lower cholesterol, such as colestipol and cholestyramine
- medicines to treat seizures, such as phenytoin
- medicines that reduce the activity of your immune system (immunosuppressants), such as ciclosporin or tacrolimus
- selective serotonin reuptake inhibitor (SSRI) antidepressants like citalopram or sertraline
- steroid medicines, such as hydrocortisone or prednisolone
- tablets that make you pee more (diuretics), such as furosemide or bumetanide
- lithium, which is used to treat mental health problems
- methotrexate, which is used to treat some inflammatory diseases and cancers
- mifepristone, which is used for ending a pregnancy (abortion)
- zidovudine, which is used to treat HIV
Mixing diclofenac with herbal remedies or supplements
It's not possible to say that complementary medicines or herbal remedies are safe to take with diclofenac.
They're not tested in the same way as prescription medicines or medicines sold in pharmacies. They're generally not tested for the effect they can have on other medicines.
Important: Medicine safety
Tell your doctor or pharmacist if you're taking any other medicines, including herbal medicines, vitamins or supplements.
10. Common questions about diclofenac
How does diclofenac work?
Diclofenac is a non-steroidal anti-inflammatory drug (NSAID). It works by reducing hormones that cause inflammation and pain in the body.
When you apply diclofenac gel, plasters or patches to your skin, it works in the same way as when you take it as a tablet or capsule. But the gel, plaster or patch only works on the area you have put it on.
When will I feel better?
Diclofenac takes 20 to 30 minutes to work if you take it as tablets or capsules.
Suppositories take a few hours to work. There's no difference in how well the tablets, capsules or suppositories work. The doses of diclofenac are the same for each.
If you're using diclofenac gel, plasters or patches on your skin, it usually takes 1 to 2 days to work. For arthritis, you may need to use the gel for up to 7 days on the painful joint to feel the full effect.
How long will I take it for?
Depending on why you're taking diclofenac, you may only need to take it for a short time. For example, if you have a sore back or toothache, you may only need to take diclofenac for 1 or 2 days.
You may need to take it for longer if you have a long-term condition, such as rheumatoid arthritis.
If you need to take diclofenac tablets or capsules for a long time, your doctor may prescribe a medicine to protect your stomach from side effects. It's best to take the lowest dose of diclofenac for the shortest time to control your symptoms.
Talk to your doctor if you're unsure how long you need to take it for.
Is it safe to take long term?
Diclofenac tablets and capsules can cause an ulcer in your stomach or gut if you take them for a long time or in big doses.
It's best to take the lowest dose that works for the shortest possible time.
If you need to take diclofenac very often or you're taking a big dose, talk to your doctor about the best way to treat your pain.
Are there other painkillers I can try?
The type of painkiller that's best depends on what type of pain you have and the cause of your pain.
If you need to take an NSAID long term, your doctor or pharmacist may recommend ibuprofen or naproxen instead of diclofenac. This is because they're less likely to cause heart problems.
Diclofenac does not work for some types of pain, such as nerve pain. Your doctor will have to prescribe a different medicine to treat peripheral neuropathy (nerve pain).
Why do I need to be careful about stomach ulcers?
Diclofenac tablets and capsules can cause an ulcer in your stomach or gut if you take them for a long time or in big doses, or if you're elderly or in poor general health.
Your doctor may tell you not to take diclofenac if you have a stomach ulcer or have had one in the past. If you need to take diclofenac but you're at risk of getting a stomach ulcer, your doctor may prescribe another medicine for you to take alongside diclofenac to protect your stomach.
It's important to take your diclofenac tablets or capsules after a meal or snack, or with a drink of milk. They'll be less likely to upset or irritate your stomach.
The most common symptom of a stomach ulcer is a burning or gnawing pain in the centre of the stomach. But stomach ulcers are not always painful and some people may have other symptoms, such as indigestion, heartburn and feeling sick.
If you're prone to stomach ulcers or have had one before, take paracetamol instead of diclofenac as it's gentler on your stomach.
Important: Stomach ulcers
Stop taking diclofenac and contact your doctor if you think you may have symptoms of a stomach ulcer. These can include intense pain in the centre of your stomach, indigestion, heartburn and feeling sick.
Is it addictive?
No, diclofenac is not addictive, but it's important to always take it as prescribed.
What will happen if I stop taking it?
When you stop taking diclofenac tablets or capsules, or stop using the suppositories, the effects will wear off after about 15 hours.
When you stop using the gel, plasters or patches, the effects will wear off after 1 or 2 days.
Will it affect my fertility?
Taking anti-inflammatory medicines, like diclofenac, in large doses or for a long time can affect ovulation in women. This may make it more difficult to get pregnant.
Do not take diclofenac if you're trying to get pregnant, or if you're having tests for infertility.
Paracetamol is a better painkiller in these situations.
Can I drink alcohol with it?
Yes, you can drink alcohol while taking diclofenac. But drinking too much alcohol may irritate your stomach.
Try to keep to the recommended guidelines of no more than 14 units of alcohol a week. A standard glass of wine (175ml) is 2 units. A pint of lager or beer is usually 2 to 3 units of alcohol.
Is there any food or drink I need to avoid?
Apart from not drinking too much alcohol, you can eat and drink normally while taking diclofenac.
Can I drive or ride a bike?
It happens rarely, but some people can feel tired, dizzy or sleepy when they take diclofenac. They may also have problems with their eyesight.
If diclofenac affects you in this way, do not drive or ride a bike until it passes and you feel OK again.