1. About bisoprolol

Bisoprolol is a medicine used to treat high blood pressure and heart failure.

If you have high blood pressure, taking bisoprolol helps to prevent future heart disease, heart attacks and strokes.

Bisoprolol is also used to prevent chest pain caused by angina. It is also used to treat atrial fibrillation and other conditions that cause an irregular heartbeat.

This medicine is only available on prescription. It comes as tablets.

2. Key facts

  • Bisoprolol slows down your heart rate and makes it easier for your heart to pump blood around your body.
  • Your very first dose of bisoprolol may make you feel dizzy, so take it at bedtime. After that, if you don't feel dizzy, it's best to take it in the morning.
  • It's usual to take bisoprolol once a day in the morning.
  • The main side effects of bisoprolol are feeling dizzy or sick, headache, cold hands or feet, constipation or diarrhoea - these are usually mild and short-lived.
  • Bisoprolol is also known by the brand names Cardicor and Congescor.

3. Who can and can't take bisoprolol

Bisoprolol can be taken by adults aged 18 and over. It isn't suitable for everyone.

To make sure it is safe for you, tell your doctor before starting bisoprolol if you have:

  • had an allergic reaction to bisoprolol or any other medicine in the past
  • low blood pressure or a slow heart rate
  • heart failure which is getting worse, heart disease, or you've recently had a heart attack
  • severe blood circulation problems in your limbs (such as Raynaud's phenomenon), which may make your fingers and toes tingle or turn pale or blue
  • metabolic acidosis - when there is too much acid in your blood
  • a lung disease or severe asthma

4. How and when to take it

It's usual to take bisoprolol once a day in the morning.

Your doctor may advise you to take your first dose before bedtime, because it can make you feel dizzy. After the first dose if you don't feel dizzy, take bisoprolol in the morning.


Take bisoprolol even if you feel well, as you will still be getting the benefits of the medicine.

How much will I take?

Your dose depends on why you need the medicine.

  • For high blood pressure or angina, you will usually start on 5mg to 10mg once a day. If this dose isn't working well enough (your blood pressure doesn't go down enough, or your angina keeps happening), your doctor may increase it up to 20mg.
  • For heart failure, you will usually start at a low dose of 1.25mg a day and increase gradually up to 10mg a day. The dose is usually increased slowly over a few months.

How to take it

Bisoprolol doesn't usually upset your tummy so you can take it with or without food.

Swallow the tablets whole with a drink of water. Some brands have a score line to help you break the tablet to make it easier to swallow. Check the information leaflet for your brand to see if you can do this.

What if I forget to take it?

If you miss a dose of bisoprolol, take it as soon as you remember that day. If you don't remember until the next day, skip the missed dose. Do not take a double dose to make up for a forgotten one.

If you forget doses often, it may help to set an alarm to remind you. You could also ask your pharmacist for advice on other ways to help you remember to take your medicine.

What if I take too much?

If you take too much bisoprolol by accident, contact your doctor or nearest hospital straight away.

An overdose of bisoprolol can slow down your heart rate and make it difficult to breathe. It can also cause dizziness and trembling.

The amount of bisoprolol that can lead to an overdose varies from person to person.

Call your doctor or go to A&E straight away if you take too much bisoprolol

If you need to go to a hospital accident and emergency (A&E) department, do not drive yourself - get someone else to drive you or call for an ambulance.

Take the bisoprolol packet or leaflet inside it plus any remaining medicine with you.

5. Side effects

Like all medicines, bisoprolol can cause side effects in some people but many people have no side effects or only minor ones. Side effects often improve as your body gets used to the medicine.

Common side effects

These common side effects happen in more than 1 in 100 people. They're usually mild and short-lived.

Talk to your doctor or pharmacist if the side effects bother you or last more than a few days:

Serious side effects

It happens rarely, but some people have serious side effects when taking bisoprolol.

Tell a doctor straight away if you have:

  • shortness of breath with a cough which gets worse when you exercise (like walking up stairs), swollen ankles or legs, chest pain, an irregular heartbeat - these are signs of heart problems
  • shortness of breath, wheezing and tightening of the chest - these can be signs of lung problems
  • yellow skin or eyes - these can be signs of liver problems

Serious allergic reaction

In rare cases, bisoprolol may cause a serious allergic reaction.

Contact a doctor straight away if:

  • you get a skin rash that may include itchy, red, swollen, blistered or peeling skin
  • you're wheezing
  • you get tightness in the chest or throat
  • you have trouble breathing or talking
  • your mouth, face, lips, tongue or throat start swelling

These are warning signs of a serious allergic reaction. A serious allergic reaction is an emergency.

These are not all the side effects of bisoprolol. For a full list, see the leaflet inside your medicine packet.


You can report any suspected side effect to the UK safety scheme.

6. How to cope with side effects

What to do about:

  • headaches - make sure you rest and drink plenty of fluids. Don't drink too much alcohol. Ask your pharmacist to recommend a painkiller. Headaches usually go away after the first week of taking bisoprolol. Talk to your doctor if the headaches last longer than a week or are severe.

  • feeling dizzy or weak - if bisoprolol makes you feel dizzy or weak, stop what you're doing and sit or lie down until you feel better. Don't drive or use tools or machinery if you're feeling tired. Don't drink alcohol as it will make you feel worse.

  • cold hands or feet - put your hands or feet under warm running water, massage them and wriggle your fingers and toes. Don't smoke or have drinks with caffeine in - these can make your blood vessels narrower and restrict your blood flow. Smoking also makes your skin colder. Try wearing mittens (they're warmer than gloves) and warm socks. Don't wear tight watches or bracelets.
  • feeling sick or vomiting - stick to simple meals and don't eat rich or spicy food. It might help to take your bisoprolol after you've eaten. If you're vomiting, try small frequent sips of water.
  • diarrhoea - drink plenty of water or other fluids. It may also help to take oral rehydration solutions, which you can buy from a pharmacy, to prevent dehydration. Don't take any other medicines to treat diarrhoea without speaking to a pharmacist or doctor.
  • constipation - eat more high-fibre foods such as fresh fruit, vegetables and cereals, and drink plenty of water. Try to exercise more regularly, for example, by going for a daily walk or run. If this doesn't help, talk to your pharmacist or doctor. Watch this short video about how to treat constipation.

7. Pregnancy and breastfeeding

Bisoprolol is not usually recommended in pregnancy or when breastfeeding.

If you're trying to get pregnant or you're already pregnant, talk to your doctor about the benefits and possible harms of taking bisoprolol.

There may be other blood pressure-lowering medicines that are safer for you. Labetalol is a similar medicine that is often recommended for high blood pressure in pregnancy.

Bisoprolol and breastfeeding

There's not a lot of information about the safety of bisoprolol if you're breastfeeding.

Small amounts of bisoprolol may get into breast milk and this can cause low blood pressure in your baby.

Talk to your doctor as other medicines for high blood pressure might be better while you're breastfeeding.

Tell your doctor if you're:

  • trying to get pregnant
  • pregnant
  • breastfeeding

8. Cautions with other medicines

There are some medicines that may interfere with the way bisoprolol works.

Tell your doctor if you're taking:

  • other medicines for high blood pressure. The combination with bisoprolol can sometimes lower your blood pressure too much. This may make you feel dizzy or faint. If this keeps happening to you, tell your doctor - they may change your dose
  • other medicines which can lower your blood pressure such as some antidepressants, nitrates (for chest pain), baclofen (a muscle relaxant), medicines for an enlarged prostate gland like tamsulosin, or Parkinson's disease medicines, such as co-careldopa and levodopa
  • non steroidal anti-inflammatory medicines (NSAIDs), such as ibuprofen - they can stop bisoprolol from working as well as it should
  • steroids, like prednisolone
  • cough medicines that contain pseudoephedrine or xylometazoline
  • medicines for diabetes - bisoprolol may make it more difficult to recognise the warning signs of low blood sugar
  • medicines for allergies, such as ephedrine, noradrenaline or adrenaline
  • medicines for asthma or chronic obstructive pulmonary disease (COPD)
  • rifampicin, an antibiotic

Mixing bisoprolol with herbal remedies or supplements

There's very little information about taking herbal remedies and supplements with bisoprolol.


For safety, tell your doctor or pharmacist if you're taking any other medicines, including herbal medicines, vitamins or supplements.

9. Common questions

How does bisoprolol work?

Bisoprolol is a type of medicine called a beta blocker.

Like other beta blockers, bisoprolol works by changing the way your body responds to some nerve impulses, especially in the heart.

It slows down your heart rate and makes it easier for your heart to pump blood around your body.

How long does bisoprolol take to work?

Bisoprolol starts to work after about 2 hours to reduce high blood pressure but it can take 2 to 6 weeks to fully take effect.

If you're taking bisoprolol for high blood pressure, you may not feel any different when you take bisoprolol. This doesn't mean the medicine isn't working and it's important to keep taking it.

If you're taking bisoprolol for angina, it will probably take a couple of weeks before you feel better. Until then, you'll still have bouts of chest pain. You may even find the pain gets worse to start with. Make sure you have your medicine (spray or tablets) for treating angina attacks with you at all times, and use it if you need to.

If you're taking bisoprolol for heart failure, it may take several weeks, even months, before you feel better.

How long will I take it for?

Usually, treatment with bisoprolol is long term, even for the rest of your life.

Is it safe to take for a long time?

Bisoprolol is generally safe to take for a long time. In fact, it works best when you take it for a long time.

What will happen if I stop taking it?

Talk to your doctor if you want to stop taking bisoprolol.

Stopping bisoprolol can make your blood pressure rise and this may increase your risk of heart attack and stroke.

If you're bothered by side effects, your doctor may be able to prescribe a different blood pressure-lowering medicine.

If you stop taking bisoprolol, it will take 2 to 3 days for it to be completely out of your body.

How does it compare with other heart medicines?

Bisoprolol works as well as other beta blockers for reducing blood pressure but it's less likely to cause side effects. That's because bisoprolol works mainly on the heart. Other beta blockers, such as propranolol, work on the heart but affect other parts of the body as well.

There are lots of other medicines to lower your blood pressure and treat chest pain or heart failure. They work in a different way to beta blockers and include:

  • ACE inhibitors - for example ramipril and lisinopril
  • angiotensin receptor blockers - for example candesartan
  • calcium channel blockers - for example amlodipine
  • diuretics (tablets which make you pee more) - for example furosemide.

Beta blockers aren't usually the first choice treatment for high blood pressure. The medicine your doctor prescribes depends on your age and ethnicity.

  • if you're under 55, you'll usually be offered an ACE inhibitor or an angiotensin receptor blocker
  • if you're 55 or older, or you're any age and of black African or Caribbean origin, you'll usually be offered a calcium channel blocker

Sometimes you may have to try other blood pressure-lowering medicines if you get side effects. Many people need to take a combination of different blood pressure-lowering tablets.

Will I need to stop bisoprolol before surgery?

Tell your doctor that you're taking bisoprolol if you're going to have a general anaesthetic (be put to sleep) for an operation. Or if you're going to have a major operation, such as a Caesarean section, without a general anaesthetic.

Your doctor may advise you to stop taking bisoprolol 48 hours before surgery. This is because if you have bisoprolol with some general anaesthetics it can lower your blood pressure too much.

Can I drink alcohol with it?

Drinking alcohol can increase the blood pressure-lowering effect of bisoprolol, which can make you feel dizzy or light-headed.

During the first few days of taking bisoprolol or after an increase in your dose, it is best to stop drinking alcohol until you see how the medicine affects you.

If you find bisoprolol makes you feel dizzy it's best to stop drinking alcohol.

Is there any food or drink I need to avoid?

You can eat and drink normally while taking bisoprolol.

Eating a healthy, balanced diet can help if you have high blood pressure or heart failure.

Will it affect my contraception?

Bisoprolol won't stop your contraception working.

However, some types of hormonal methods of contraception, like the combined contraceptive pill and contraceptive patch, aren't usually recommended for women taking bisoprolol and other medicines for high blood pressure. This is because some hormonal contraceptives can raise your blood pressure and stop bisoprolol working properly.

Talk to your doctor if you're taking combined hormonal contraceptives.

Will it affect my fertility?

It's unlikely that bisoprolol affects fertility in men or women. However there's not enough evidence to say for certain.

If you're trying for a baby, or you're having problems getting pregnant while on bisoprolol, speak to your doctor.

Will it affect my sex life?

Some people on bisoprolol say their sex drive goes down or they can't get an erection. However, this isn't a common side effect and there isn't enough evidence to say for sure that bisoprolol is causing it.

If you're having problems with your sex life, talk to your doctor.

Do I need to avoid playing sports?

You don't need to stop playing sports if you take bisoprolol. But don't push yourself too much.

Regular exercise is good for you because it lowers blood pressure by keeping your heart and blood vessels in good condition.

Be aware, though, that in some sports bisoprolol is not allowed if you're competing at a high level.

Can I drive or ride a bike?

Bisoprolol can make some people feel dizzy - especially when you first start taking it or after taking a bigger dose.

If this happens to you, don't drive a car, ride a bike, or use tools or machinery.

Can lifestyle changes help?

You can boost the health of your heart by making some key lifestyle changes. These will also help if you have high blood pressure.

  • Stop smoking - smoking increases your heart rate and blood pressure. Quitting smoking brings down your blood pressure and relieves heart failure symptoms. Try and avoid secondhand smoke.
  • Drink alcohol sensibly - drinking too much alcohol raises blood pressure over time. It makes heart failure worse too. Men and women shouldn't drink more than 14 units of alcohol a week.
  • Be more active - regular exercise lowers blood pressure by keeping your heart and blood vessels in good condition. It doesn't need to be too energetic - walking every day is enough.
  • Eat healthily - aim to eat a diet that includes plenty of fruit and veg, wholegrains, fat-free or low-fat dairy products and lean proteins. It's a good idea to cut down on salt too. Eating too much salt is the biggest cause of high blood pressure - the more salt you eat, the higher your blood pressure will be. Aim for no more than 6g of salt a day.
  • Manage stress - when you're anxious or upset, your heart beats faster, you breathe more heavily and your blood pressure often goes up. This can make heart failure worse too. Find ways to reduce stress in your life. To give your heart a rest, try napping or putting your feet up when possible. Spend time with friends and family to be social and help avoid stress.
  • Vaccinations - if you have heart failure, it's recommended that you have a flu jab every year and a pneumonia vaccination every 5 years. Ask your doctor about these vaccinations. You can have them free on the NHS.

Page last reviewed: 20/12/2017
Next review due: 20/12/2020