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Taking valproic acid with other medicines and herbal supplements - Brand names: Belvo, Depakote, Convulex, Syonell

Cautions with other medicines

There are some medicines that may affect how valproic acid works. Valproic acid can also affect the way other medicines work.

Tell your doctor if you're taking:

  • any other medicines for epilepsy such as carbamazepine
  • medicines for preventing blood clots such as warfarin
  • aspirin
  • cimetidine, a medicine for stomach ulcers
  • medicines to treat HIV and AIDS such as ritonavir
  • antibiotics such as erythromycin
  • medicines for depression or other mental health problems, such as venlafaxine, quetiapine or diazepam
  • cholesterol-lowering medicines such as cholestyramine
  • medicines to prevent malaria such as mefloquine or chloroquine

Mixing valproic acid with herbal remedies and supplements

It's not possible to say whether complementary medicines, herbal remedies and supplements are safe to take with valproic acid. They're not tested in the same way as pharmacy and prescription medicines. They're generally not tested for the effect they have on other medicines.

Important: Medicine safety

Tell your doctor or pharmacist if you're taking any other medicines, including herbal remedies, vitamins or supplements.

Page last reviewed: 11 March 2025
Next review due: 11 March 2028