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About sotrovimab (Xevudy)

Sotrovimab is a biological medicine. It's also known as a neutralising monoclonal antibody (nMAb). It's used to treat COVID-19.

nMAbs are synthetic proteins that act like human antibodies in the immune system. They are made by cloning an antibody that can stick to the spike protein of the virus and neutralise it. They stick to the virus and stop it from getting into your lungs and causing an infection.

If you are eligible for COVID-19 treatment you will usually be offered an antiviral medicine called Paxlovid as a first treatment. However, if it’s not suitable for you, you may be offered sotrovimab.

It's given to you through a drip, usually in your arm (infusion). It will be given in hospital or at a local centre.

If you have tested positive for COVID-19 and are eligible, call your GP, NHS 111 or hospital specialist as soon as possible. This is so they can consider referring you for an assessment for COVID-19 treatment

Find out more about how to get treatments for COVID-19.

Key facts

  • Sotrovimab will keep working in your body and help prevent reinfection from COVID-19 for at least 4 weeks.
  • The dose of sotrovimab is 500mg. It's given to you through a drip, usually in your arm (infusion) over 30 minutes. You'll only need 1 dose.
  • The most common side effects include feeling sick, feeling dizzy, an itchy rash or redness or warmth on your skin.
  • If you feel dizzy after your treatment, do not drive a car, ride a bike, or use tools or machinery.

Page last reviewed: 20 December 2021
Next review due: 20 December 2024