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Taking sertraline with other medicines and herbal supplements

Cautions with other medicines

Some medicines can affect the way sertraline works and increase the chances of you having side effects.

Tell your doctor if you are taking any of these medicines before starting sertraline:

  • any medicines that affect your heartbeat – sertraline can make your heart beat faster or cause an irregular heartbeat (arrhythmia)
  • any other medicines for depression that you are taking now or have taken in the past – some antidepressants can affect sertraline to cause very high blood pressure even after you've stopped taking them

Mixing sertraline with herbal remedies and supplements

Do not take St John's wort, the herbal remedy for depression, while you're being treated with sertraline as this will increase your risk of side effects.

There's very little information about taking other herbal remedies and supplements with sertraline. It's not possible to say whether they are safe to take together. They're not tested in the same way as pharmacy and prescription medicines.

Important: Medicine safety

Tell your doctor or pharmacist if you're taking any other medicines, including herbal remedies, vitamins or supplements.

Page last reviewed: 2 February 2022
Next review due: 2 February 2025