Cautions with other medicines
Some medicines and omeprazole can affect each other and make it more likely that you'll have side effects or stop one of the medicines working properly.
Tell your doctor if you're taking these medicines before you start omeprazole treatment:
- heart medicines, such as digoxin
- cilostazol, a medicine that treats peripheral arterial disease (PAD)
- antifungal medicines, such as itraconazole, ketoconazole, posaconazole and voriconazole
- methotrexate, a medicine that treats psoriasis and rheumatoid arthritis
- HIV medicines
- phenytoin, an epilepsy medicine
- rifampicin, an antibiotic
- clopidogrel and warfarin, medicines to prevent or treat blood clots
These are not all the medicines that may not mix well with omeprazole. For a full list, see the leaflet inside your medicine packet.
Taking omeprazole with painkillers
It is safe to take painkillers such as paracetamol or ibuprofen at the same time as omeprazole.
It's best to take ibuprofen with, or just after, a meal so it does not upset your stomach.
Mixing omeprazole with herbal remedies or supplements
Do not take St John's wort, the herbal remedy for depression, while you're taking omeprazole. It may stop omeprazole working as well as it should.
There's not enough information to say that other complementary medicines and herbal remedies are safe to take with omeprazole. They're not tested in the same way as pharmacy and prescription medicines. They're generally not tested for the effect they have on other medicines.
Important: Medicine safety
Tell your doctor or pharmacist if you're taking any other medicines, including herbal remedies, vitamins or supplements.