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Taking nitrofurantoin with other medicines and herbal supplements - Brand name: Macrobid

Cautions with other medicines

There are some medicines that do not mix well with nitrofurantoin.

Tell your doctor if you're taking any other medicines before you start taking nitrofurantoin, including:

  • indigestion remedies known as antacids, particularly those that contain magnesium
  • cystitis remedies you can buy from a pharmacy
  • antibiotics known as quinolones, including nalidixic acid, ciprofloxacin, levofloxacin, norfloxacin, ofloxacin and moxifloxacin

Typhoid vaccines given by mouth may not work properly if you're taking nitrofurantoin. It does not affect typhoid vaccines given by injection.

These are not all the medicines that may cause problems if you take them with nitrofurantoin. For a full list, see the leaflet inside your medicine packet

Mixing nitrofurantoin with herbal remedies and supplements

There's very little information about taking herbal remedies with nitrofurantoin. They're not tested in the same way as pharmacy and prescription medicines. They're generally not tested for the effect they have on other medicines.

Important: Medicine safety

Tell your doctor or pharmacist if you're taking any other medicines, including herbal remedies, vitamins or supplements.

Page last reviewed: 6 January 2026
Next review due: 6 January 2029