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Taking melatonin with other medicines and herbal supplements - Brand names: Circadin, Adaflex, Ceyesto, Slenyto, Syncrodin

Cautions with other medicines

Some medicines and melatonin can affect each other and increase your risk of side effects.

Lots of medicines may increase or decrease the drowsy-making (sedating) effects of melatonin.

Tell your doctor or pharmacist if you're taking any of these medicines before taking melatonin:

Mixing melatonin with herbal remedies and supplements

Do not take any herbal remedies that make you feel sleepy while taking melatonin.

They can increase the sedating effects of your medicine and make you feel much more drowsy.

There's not enough information to say that other, non-drowsy herbal remedies and supplements are safe to take with melatonin. They're not tested in the same way as pharmacy and prescription medicines. They're generally not tested for the effect they have on other medicines.

Important: Medicine safety

Tell your doctor or pharmacist if you're taking any other medicines, including herbal remedies, vitamins or supplements.

Page last reviewed: 13 February 2023
Next review due: 13 February 2026