Isotretinoin gel (Isotrex)

1. About isotretinoin gel

Isotretinoin gel is an effective treatment for mild to moderate acne (spots).

It can be used on its own or with other creams, gels or antibiotic tablets.

Isotretinoin also comes as capsules that you swallow, if you are looking for information on these, read isotretinoin capsules (Roaccutane).

2. Key facts

  • Isotretinoin gel takes 6 to 8 weeks to work.
  • The most common side effects of isotretinoin gel are red, sore or dry skin and lips. These side effects go away when you stop the treatment.
  • If you're a woman, it's very important not to become pregnant while using isotretinoin gel and for at least 1 month after stopping. Isotretinoin can harm an unborn baby.
  • Isotretinoin gel can make your skin sensitive to sunlight. For safety, stay out of bright sun and use a high factor sun cream even on cloudy days.
  • The brand name for isotretinoin gel is Isotrex.

3. Who can and can't use isotretinoin gel

Isotretinoin gel is for teenagers and adults with mild to moderate acne.

Do not give isotretinoin gel to children under the age of 12 or before puberty.

Isotretinoin gel may not be suitable for some people. Tell your doctor before starting treatment if you:

  • have had an allergic reaction to isotretinoin or any other medicines in the past
  • get eczema
  • have had skin cancer
  • are pregnant or think you could be pregnant, or you're breastfeeding

4. Side effects

Like all medicines, isotretinoin gel can cause side effects, although not everyone gets them. Side effects will usually go away when you stop using the gel.

Common side effects

Common side effects of isotretinoin gel happen in more than 1 in 10 people.

Talk to your doctor or pharmacist if these side effects bother you or don't go away:

  • dry skin or lips
  • red or peeling skin
  • skin irritation or itching
  • skin becoming more sensitive to sunlight

Serious side effects

Sometimes these skin reactions can be more severe. If you have severe burning, peeling, redness or itchiness of your skin, stop using the gel and see a doctor straight away.

Serious allergic reaction

In rare cases, it's possible to have a serious allergic reaction (anaphylaxis) to isotretinoin gel.

Contact a doctor straight away if:

  • you get a skin rash that may include itchy, red, swollen, blistered or peeling skin
  • you're wheezing
  • you get tightness in the chest or throat
  • you have trouble breathing or talking
  • your mouth, face, lips, tongue or throat start swelling

These are warning signs of a serious allergic reaction. A serious allergic reaction is an emergency.

These are not all the side effects of isotretinoin gel. For a full list see the leaflet inside your medicines packet.


You can report any suspected side effect to the UK safety scheme.

5. How to cope with side effects

What to do about:

  • dry skin or lips - apply a moisturiser and lip balm regularly (the best type of moisturiser is an oil-free face moisturiser for sensitive skin) and try to keep your showers shorter than 2 minutes, using lukewarm water rather than hot.
  • red or peeling skin - try using the gel less often, or stop using it for a few days until the irritation goes away, then start again. Speak to your doctor if the symptoms become severe.
  • skin irritation or pain - try using the gel less often (maybe once a day instead of twice, or every other day), or you could stop using the gel for a few days until the irritation goes away and then try using it again. If the irritation doesn't go away, stop using the gel and speak to your doctor.
  • your skin becoming sensitive to sunlight - stay out of bright sun and use a high factor oil-free sun cream (SPF 15 or above) even on cloudy days. Do not use a sunlamp or sunbeds.

6. How to use the gel

Apply isotretinoin gel once or twice a day as instructed by your doctor.

Always wash and dry your skin, and completely remove any make-up, before you apply the gel. This will help it work better.

Put a thin layer of the gel on the affected skin using your fingertips and smooth it in. Apply it to all areas of skin that have acne and not just each spot.

You only need to apply a thin layer of gel. Try not to use too much, especially where the gel could run into your eyes or build up in folds of skin. Using more gel will not make your spots clear up more quickly.

Do not use isotretinoin gel on irritated areas of skin - for example, cuts, burns or sunburn - as it can make the irritation worse.

Only ever use isotretinoin gel on your skin, and keep it away from your mouth, lips and eyes.

What if I forget to use it?

If you forget to apply the gel, skip the missed dose and apply the next dose at the usual time.

Never apply a double dose. Never apply an extra dose to make up for a missed one.

If you often forget doses, it may help to set an alarm to remind you. You could also ask your pharmacist for advice on other ways to help you remember.

What if I use too much?

If you use too much isotretinoin gel or use it more often than you should, it may make your skin red or irritated. If this happens, use the gel less often or stop using it for a few days.

Will the amount I use go up or down?

The dose of isotretinoin gel will probably not change, although if your skin becomes irritated, your doctor may suggest you use it less often for a while.

7. Advice for women

This medicine is likely to harm a baby.

Use reliable contraception to prevent pregnancy while you're using isotretinoin gel. Some brands of contraceptive pill can also help with acne.

If you become pregnant during treatment with isotretinoin gel, stop using it and talk to your doctor straight away.

Do not breastfeed while you're using isotretinoin gel. This medicine can get into breast milk and harm your baby.


Do not use isotretinoin gel if you're pregnant, think you're pregnant or are breastfeeding. This medicine can harm a baby.

8. Cautions with other medicines

Some medicines and isotretinoin gel can interfere with each other and make it more likely that you'll have side effects.

Tell your doctor if you're taking these medicines before you start isotretinoin gel:

  • other acne medicines - using both together may make skin irritation worse
  • benzoyl peroxide cream or gel (another acne treatment) - it may make isotretinoin gel less effective

Mixing isotretinoin gel with herbal remedies and supplements

There's very little information about taking herbal remedies and supplements while you use isotretinoin gel.


For safety, tell your doctor or pharmacist if you're taking any other medicines, including herbal remedies, vitamins or supplements.

9. Common questions

Related conditions

Page last reviewed: 18/01/2019
Next review due: 18/01/2022