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How and when to take isotretinoin capsules

It's important to take isotretinoin capsules as instructed by your doctor.

Dosage and strength

Isotretinoin comes as 10mg or 20mg soft capsules.

The dose of isotretinoin capsules varies from person to person, and depends on your body weight.

The usual starting dose is 0.5mg per kilogram body weight per day (0.5 mg/kg/day). So if you weigh 60kg, your dose will usually start at 30mg a day.

Usually, you take isotretinoin capsules once or twice a day.

Changes to your dose

After a few weeks, your doctor may change your dose of isotretinoin capsules. You may need a higher dose if your acne is not getting better. You may need a lower dose if you have side effects.

Speak to your doctor if you think your dose is too high or too low.

How to take it

Swallow the capsules whole with a drink of water.

Take isotretinoin capsules with food to make sure they work properly. It's best to take them straight after a meal or snack.

How long to take it for

A treatment course of isotretinoin capsules usually lasts for 16 to 24 weeks (around 4 to 6 months). Acne will usually keep getting better for up to 8 weeks after stopping treatment.

Most people have clear skin after that time, but some will need another round of treatment.

If you forget to take it

If you forget to take the capsules, take them as soon as you remember, unless it's nearly time for your next dose. In this case, skip the missed dose and take your next dose at the usual time.

Never take 2 doses at the same time to make up for a forgotten dose. Never take an extra dose to make up for a missed one.

If you often forget doses, it may help to set an alarm to remind you. You could also ask your pharmacist for advice on other ways to help you remember to take your medicine.

If you take too much

Urgent advice: Contact 111 for advice now if:

  • you take more than your prescribed dose of isotretinoin, even if you have no symptoms

Go to 111.nhs.uk or call 111

If you need to go to A&E, take the isotretinoin packet or leaflet inside it plus any remaining medicine with you.

Page last reviewed: 25 February 2022
Next review due: 25 February 2025