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Pregnancy, breastfeeding and fertility while taking glimepiride

Glimepiride and pregnancy

Glimepiride is not recommended in pregnancy as there is little information about its safety during pregnancy.

Other medicines used to treat diabetes, such as insulin and metformin, are safe to take while pregnant.

If you are pregnant or thinking of getting pregnant, talk to your doctor as they will need to review your treatment. They will be able to suggest a different medicine that is safer for you to take in pregnancy.

Glimepiride and breastfeeding

Glimepiride is not usually recommended while breastfeeding. We do not know how much glimepiride passes into breast milk, but it is possible it could lower your baby's blood sugar level.

If you are breastfeeding, or planning to breastfeed, talk to your doctor about what's best for you and your baby. They will need to review your treatment and may be able to suggest a different medicine for you, particularly if you're breastfeeding a newborn or premature baby.

If your doctor says it's OK to keep taking it while breastfeeding, contact your health visitor, midwife, pharmacist or doctor as soon as possible if your baby:

  • is not feeding as well as usual
  • is being sick or has diarrhoea
  • seems unusually sleepy or irritable
  • is paler, or more sweaty, than usual
  • seems hungrier than usual
  • is peeing more
  • is causing you any other concerns

Glimepiride and fertility

There's no evidence to suggest that taking glimepiride reduces fertility in either men or women.

Speak to a pharmacist or your doctor if you're trying to get pregnant. They may want to review your treatment.

Non-urgent advice: Tell your doctor if you're:

  • trying to get pregnant
  • pregnant
  • breastfeeding

For more information about how diabetes medicines can affect you and your baby during pregnancy, visit the Best Use of Medicines in Pregnancy (BUMPS) website.

Page last reviewed: 14 March 2022
Next review due: 14 March 2025