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About eplerenone - Brand name: Inspra

Eplerenone is usually taken for heart failure.

It helps to keep your symptoms of heart failure under control and reduce the risk of your heart getting weaker by:

  • reducing your blood pressure
  • controlling the amount of salt and water in your body
  • improving your heart function

It works by blocking the action of a hormone called aldosterone.

Eplerenone comes as tablets and is only available on prescription.

Key facts

  • You'll usually take eplerenone once a day, but your doctor may tell you to take it every other day if you get side effects or have any problems with your kidneys.
  • Side effects include feeling dizzy, headaches, not being able to sleep, and a cough.
  • Taking eplerenone can raise the levels of potassium in your blood. This can cause muscle cramps and diarrhoea. You'll have regular blood tests while you're taking it.
  • It's important to keep taking eplerenone even if you feel well. You'll still get the benefits of the medicine.
  • If you're on or want to start a low-salt diet, talk to your doctor. Some salt substitutes may increase your potassium levels.

Page last reviewed: 2 February 2024
Next review due: 2 February 2027