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About dosulepin

Dosulepin is an antidepressant medicine that is used to treat depression.

Occasionally, dosulepin is also used for some types of nerve pain, such as fibromyalgia, and to prevent migraines.

Dosulepin is available on prescription, but usually only if you're already taking it and have not had any serious side effects.

It comes as capsules and tablets.

Key facts

  • Unless recommended by a specialist, dosulepin is no longer prescribed to new patients. This is because of concerns about side effects.
  • For depression, it usually takes 4 to 6 weeks to work fully. It usually takes 2 to 6 weeks to work fully if you're taking it for pain or migraine.
  • Common side effects of dosulepin include constipation, feeling dizzy, a dry mouth, feeling sleepy, difficulty peeing or headaches.
  • If dosulepin makes you feel sleepy, do not drive, cycle or use machinery until you feel better.
  • Dosulepin can cause withdrawal symptoms if you stop taking it suddenly. Talk to your doctor if you're thinking of stopping.

Page last reviewed: 3 March 2022
Next review due: 3 March 2025