Skip to main content

Taking chlorphenamine with other medicines and herbal supplements - Brand names: Piriton, Allerief, Pollenase

Cautions with other medicines

Some medicines and chlorphenamine can affect each other and increase the chances of you having side effects.

Check with your pharmacist or doctor if you're taking any other medicines, including:

  • a type of antidepressant called a monoamine oxidase inhibitor, such as phenelzine
  • phenytoin (an anti-epilepsy medicine)
  • any medicines for anxiety or to help you sleep
  • any medicine that makes you drowsy, gives you a dry mouth, or makes it difficult for you to pee – taking chlorphenamine might make these side effects worse

These are not all the medicines that may cause problems if you take them with chlorphenamine. For a full list, see the leaflet inside your medicine packet.

Taking chlorphenamine with painkillers

It's safe to take chlorphenamine with painkillers like paracetamol or ibuprofen that you buy from a pharmacy or shop.

But if you take chlorphenamine with painkillers that contain codeine (such as co-codamol) or other prescription painkillers, you're more likely to have side effects.

Mixing chlorphenamine with herbal remedies and supplements

There might be a problem taking some herbal remedies and supplements alongside chlorphenamine, especially ones that cause side effects such as sleepiness, a dry mouth or making it difficult to pee.

There's not enough information to say that other herbal remedies and supplements are safe to take with chlorphenamine. They're not tested in the same way as pharmacy and prescription medicines. They're generally not tested for the effect they have on other medicines.

Important: Medicine safety

Tell your doctor or pharmacist if you're taking any other medicines, including herbal remedies, vitamins or supplements.

Page last reviewed: 14 May 2025
Next review due: 14 May 2028