The symptoms of syphilis are similar for men and women. They're often mild and difficult to recognise, and you may pass on the infection without knowing you have it.
The symptoms tend to change over time and may come and go.
Even if the symptoms do improve, there's still a risk you could pass the infection on or develop serious problems if you don't get treatment.
Early symptoms of syphilis
The first symptoms of syphilis usually develop around 2 or 3 weeks after infection, although they can start later than this.
This stage of the infection is known as "primary syphilis".
- the main symptom is a small, painless sore or ulcer called a chancre that you might not notice
- the sore will typically be on the penis, vagina, or around the anus, although it can sometimes appear in the mouth or on the lips, fingers or buttocks
- most people only have one sore, but some people have several
- you may also have swollen glands in your neck, groin or armpits
These symptoms usually pass within 2 to 8 weeks. But if the infection isn't treated, it may progress to a second stage.
Later symptoms of syphilis
Further symptoms may develop a few weeks after the initial symptoms have passed. This is known as "secondary syphilis".
Symptoms of secondary syphilis include:
- a blotchy red rash that can appear anywhere on the body, but often develops on the palms of the hands or soles of the feet
- small skin growths (similar to genital warts) – on women these often appear on the vulva and for both men and women they may appear around the anus
- white patches in the mouth
- flu-like symptoms, such as tiredness, headaches, joint pains and a high temperature (fever)
- swollen glands
- occasionally, patchy hair loss
These symptoms usually pass within a few weeks, although they may come and go over several months before they disappear.
You'll still be infected even if you don't have symptoms. This is known as "latent syphilis" and it can last for decades and lead to serious problems if not treated.
It's still possible to pass on the infection during this stage, although this usually only happens within 2 years of becoming infected.
Serious problems if left untreated
Without treatment, a syphilis infection can last for years or decades without causing any symptoms.
Eventually, it can spread to parts of the body such as the brain or nerves and cause serious and potentially life-threatening problems. This is known as "tertiary syphilis".
People with tertiary syphilis may experience:
- dementia symptoms
- loss of co-ordination
- vision problems or blindness
- heart problems
Syphilis is still treatable at this stage, but it's sometimes not possible to reverse any damage that's already been done.
Page last reviewed: 7 February 2019
Next review due: 7 February 2022