Psychosis can be caused by a mental (psychological) condition, a general medical condition, or a substance such as alcohol or drugs.
These three main causes are described in more detail below.
The following conditions have been known to trigger psychotic episodes in some people:
- schizophrenia – a mental health condition that causes hallucinations and delusions
- bipolar disorder – a person with bipolar disorder can have episodes of low mood (depression) and highs or elated mood (mania)
- severe stress or anxiety
- severe depression – feelings of persistent sadness, including postnatal depression, which some women experience after having a baby
- lack of sleep
The underlying psychological cause often influences the type of psychotic episode someone experiences.
For example, a person with bipolar disorder is more likely to have grandiose delusions. Someone with depression or schizophrenia is more likely to develop persecutory delusions.
General medical conditions
The following medical conditions have been known to trigger psychotic episodes in some people:
A person can also experience a psychotic episode if they suddenly stop drinking alcohol or taking drugs after using them for a long time. This is known as withdrawal.
It's also possible to experience psychosis after drinking large amounts of alcohol or if you're high on drugs.
Drugs known to trigger psychotic episodes include:
- amphetamine (speed)
- methamphetamine (crystal meth)
- mephedrone (MCAT or miaow)
- MDMA (ecstasy)
- LSD (acid)
- psilocybins (magic mushrooms)
In rare situations, psychosis can also occur as a side effect of some types of medication or as a result of an overdose of that medication.
Never stop taking a prescribed medication unless advised to do so by your GP or another qualified healthcare professional responsible for your care.
See your GP if you're experiencing psychotic side effects caused by medication.
There's been a great deal of research into how psychosis affects the brain and how changes in the brain can trigger symptoms of psychosis.
Researchers believe dopamine plays an important role in psychosis.
Dopamine is a neurotransmitter, one of many chemicals the brain uses to transmit information from one brain cell to another. It's associated with how we feel whether something is significant, important, or interesting.
Disruption to these important brain functions may explain the symptoms of psychosis.
Evidence for the role of dopamine in psychosis comes from several sources, including brain scans and the fact medications known to reduce the effects of dopamine in the brain also reduce the symptoms of psychosis.
Page last reviewed: 23 December 2016
Next review due: 23 December 2019