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Causes - Ankylosing spondylitis

In ankylosing spondylitis (AS) several parts of the lower spine become inflamed, including the bones in the spine (vertebrae) and spinal joints.

Over time this can damage the spine and lead to the growth of new bone. In some cases this can cause parts of the spine to join up (fuse) and lose flexibility (ankylosis).

It's not known exactly what causes AS, but in many cases there seems to be a link with a particular gene known as HLA-B27.

HLA-B27 gene

Research has shown more than 9 out of 10 people with AS carry a particular gene known as human leukocyte antigen B27 (HLA-B27).

Having this gene does not necessarily mean you'll develop AS. It's estimated 8 in every 100 people in the general population have the HLA-B27 gene, but most do not have AS.

It's thought having this gene may make you more vulnerable to developing AS. The condition may be triggered by 1 or more environmental factors, although it's not known what these are.

Testing for this gene may be carried out if AS is suspected. However, this test is not a very reliable method of diagnosing the condition because some people can have the HLA-B27 gene but not have ankylosing spondylitis.

Read about how ankylosing spondylitis is diagnosed.

Can ankylosing spondylitis be inherited?

AS can run in families, and the HLA-B27 gene can be inherited from another family member.

If you have AS and tests show you carry the HLA-B27 gene then there is a 1 in 2 chance that you could pass on the gene to any children you have. It is estimated that between 5 to 20% of children with this gene will then go on to develop AS.

Page last reviewed: 11 July 2019
Next review due: 11 July 2022