Cautions with other medicines
Some medicines affect the way co-codamol works. Co-codamol can also stop some medicines working as well as they should.
Tell your doctor if you're taking:
- sleeping pills or tranquillisers – particularly benzodiazepines such as diazepam, temazepam or lorazepam
- antidepressants – some types do not mix with co-codamol
- medicines to stop you feeling or being sick such as domperidone or metoclopramide
- medicines that help to prevent blood clots (anticoagulants) such as warfarin
- medicines to treat infections, particularly rifampicin or ciprofloxacin
- epilepsy medicines
Taking co-codamol with other painkillers
It's safe to take co-codamol with ibuprofen and aspirin.
Do not take co-codamol with paracetamol, or other medicines that contain paracetamol, unless you've been advised to by a doctor. Co-codamol already contains paracetamol so you could be at risk of paracetamol overdose.
Medicines that have paracetamol in them include painkillers like Tramacet and co-dydramol, migraine remedies, and some cough and cold remedies like Lemsip and Night Nurse.
Important
Before taking co-codamol with any other medicines, check the label to see whether they contain paracetamol.
Mixing co-codamol with herbal remedies and supplements
There's not enough information to say that complementary medicines, herbal remedies and supplements are safe to take with co-codamol.
They're not tested in the same way as pharmacy and prescription medicines. They're generally not tested for the effect they have on other medicines.
Important: Medicine safety
Tell your doctor or pharmacist if you're taking any other medicines, including herbal remedies, vitamins or supplements.