Obesity 

Treating obesity 

Important safety advice about the weight-loss medication sibutramine (Reductil)

In January 2010, the European Medicine Agency (EMA) recommended that medications containing sibutramine should be withdrawn across the European Union due to a concern over its safety.

In the UK, the main licensed medication that contains sibutramine is called Reductil. Other medications that contain sibutramine include Reduxade and Zelium.

The EMA has recommended that medication that contains sibutramine should be withdrawn because research has shown that people taking the medication have an increased risk of having a heart attack or stroke.

If you are currently taking Reductil, or any other medication that contains sibutramine, you should make an appointment to see your GP to discuss alternative methods of losing weight.

If you wish to stop taking the medication before seeing your GP, it is safe to do so although you may experience some temporary side effects, such as headaches and an increased appetite.

See the European Medicine Agency website for more information about the EMA’s recommendation to withdraw sibutramine.

The aim of treatment for obesity is to lose weight in order to improve your general quality of life, both physically and psychologically (see symptoms). For example, losing weight may help you sleep better, or help you to improve your self-esteem.

The best way to treat obesity is to reduce the amount of calories in your diet and to exercise more. The type of diet and exercise that will benefit you, and that you can follow safely, will vary from person to person. You should visit your GP before making any significant changes to your lifestyle.

Diet advice

A healthy diet should contain:

  • meals based on starchy, high-fibre carbohydrates, such as wholegrain bread, pasta and rice
  • at least five portions of fruit and vegetables every day
  • a moderate amount of low-fat protein, milk and dairy products
  • a very small amount of foods that are high in fat, sugar or salt

In order to lose weight, you need to eat a healthy diet and reduce the amount of calories in your diet. This will mean changing your eating habits. You need to do this a way that you find acceptable, and that you can maintain long-term (see tips for weight loss, in the box to the right).

Types of diet

Your GP may recommend a calorie-controlled diet. This will be based on how much you are currently eating, and then attempting to cut the amount of calories you eat every day by around 600. Alternatively, you may be advised to follow a low-fat diet. See diet for tips to cut down the amount of fat and sugar in your diet.

A calorie-controlled or low-fat diet should only be attempted with expert support and advice. You should also have a follow-up appointment with your GP to check your progress.

If you attempt a low-calorie diet (only 1,000-1,600 calories a day) without the advice of a health professional, you may miss out some of the vital nutrients you need to stay healthy.

Very-low-calorie diets (VLCDs) may be used by people who are obese and have reached a plateau in their weight loss. NICE defines VLCDs as being less than 1,000 calories a day. They should only be used with expert support and any diet of less than 600 calories a day should be used only under the supervision of a qualified health professional.

A number of published studies suggest that VLCDs are effective in helping obese people to lose weight. For example, a 2009 randomised controlled trial concluded that there was an average weight loss of 31kg for obese patients who followed a very-low-calorie diet compared with 4kg for those following a low-carbohydrate/high-protein diet. 

Diets that are very restrictive, for example those that cut out entire food groups, should not be used. This includes diets that cut out all carbohydrates or proteins. These diets are not usually sustainable in the long-term, and may be harmful. 

Further information

There is much more information on losing weight in the Live Well section of the website. This section contains information on:

Children and diet

As children are still growing, they may need to follow a special kind of diet to make sure that they are still getting all the nutrients they need to develop healthily. If your child is overweight or obese, consult your GP before making any significant changes to their diet.

Increase your exercise

Research suggests that increasing the amount of exercise you do is an effective way to lose weight, and the results are even better when combined with changes to your diet.

The advice from your GP about exercise will vary depending on how fit you are to start with, and what it is safe for you to do. You should start by decreasing the amount of time you are physically inactive, such as how long you spend watching television or sitting at a computer.

You should then build up slowly to at least 150 minutes (2 hours and 30 minutes) of moderate-intensity aerobic activity (i.e. cycling or fast walking) every week.

Moderate intensity means that you are breathing slightly more than normal, but you can still comfortably talk as you exercise.

Types of exercise

The most effective types of exercise are ‘aerobic’ activities. Aerobic activities are any kind of rhythmic, moderate intensity exercises that use the large muscles in your legs and buttocks. The exercise should raise your heart rate and make you breathe harder. 

Recommended types of physical exercise include:

  • activities that can be incorporate into everyday life, such as brisk walking, gardening, or cycling,
  • supervised exercise programmes, and
  • activities such as swimming, walking (where you aim to walk a certain number of steps a day), and stair climbing.

Chose physical activities that you enjoy, as you are more likely to continue doing them.

Further information

For more information, see the fitness section of Live Well. This includes information on:

Children and exercise

Children should be encouraged to do at least 60 minutes of moderate activity each day. The activity can be in one session, or several sessions that last 10 minutes, or more. As with adults, children who are overweight, or obese, may need to do more than 60 minutes of exercise. You should check with your GP before your child starts a new exercise programme.

Medication

Medication for obesity may be available from your GP in some cases. You need to show you can lose weight on a calorie controlled diet before it is considered. Medication is normally one part of a weight loss programme, and requires a long-term change in lifestyle for lasting results.

The only medication currently prescribed is orlistat. See the box to the left for information on sibutramine, which is no longer used due to safety concerns.

Orlistat

Ortlisat works by blocking the action of an enzyme (a protein that speeds-up and controls chemical reactions in the body) that is used to digest fat. The undigested fat is not absorbed into your body, and is passed out with your faeces (stools). As you are absorbing less fat, you should lose weight.

One orlistat capsule is taken with each main meal (a maximum of three capsules a day). You can take the capsule either before, during, or up to one hour after each meal.

If you miss a meal, or the meal does not contain any fat, you may not need to take the orlistat capsule. Your GP should explain this to you, or you can check the patient information leaflet that comes with your medication.

You have to have made significant effort to lose weight through diet, exercise or changing your lifestyle before taking orlistat. Even then, orlistat is only prescribed if you are on a low calorie diet and you have:

  • a body mass index (BMI) of 28 or more, and other conditions related to weight, such as high blood pressure (hypertension), or
  • a BMI of 30 or more.

Treatment with orlistat must be combined with a low fat diet and other weight loss strategies, such as doing more exercise. If you are prescribed orlistat, you will also be offered advice and support about diet, exercise and making lifestyle changes.

Treatment with orlistat should only continue beyond three months if you have lost 5% of your body weight. Orlistat usually starts to affect how you digest fat within 1-2 days. If orlistat has not worked after three months, it is unlikely to be an effective treatment for you.

If you have type 2 diabetes (a condition caused by too much glucose in the blood), it may take you longer to lose weight using orlistat. Your target weight loss after three months may therefore be slightly lower.

If orlistat is successful after three months, your prescription may be continued for up to a year. After that, your GP will review your condition and decide whether you should continue with orlistat or not. 

Side effects and warnings

Side effects of orlistat include:

  • fatty or oily stools,
  • needing the toilet urgently,
  • passing stools more frequently,
  • oily discharge from your rectum (the storage area at the end of the bowel that holds the stools) - you may have oily spots on your underwear, 
  • flatulence (wind),
  • abdominal (stomach) pain,
  • headaches, and
  • upper respiratory tract infections – such as a cold or sore throat. 

Side effects are much less likely if you stick to a low fat diet.

Women taking an oral contraceptive pill are advised to use an additional method of contraception, such as a condom, if they experience severe diarrhoea while taking orlistat. This is because if you have diarrhoea, your contraceptive pill may not be absorbed by your body, and so may not be effective.

Orlistat is not prescribed to:

  • pregnant women
  • breastfeeding women
  • children

Children and medication

The use of medication to treat obesity is usually not recommended for children (under 18 years of age). In exceptional circumstances, for example if their obesity places their life in danger, orlistat may be considered for children over 12 years of age, with specialist supervision.

Last reviewed: 25/02/2010

Next review due: 25/02/2012

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Comments are personal views. Any information they give has not been checked and may not be accurate.

User363614 said on 03 September 2011

The explanation of the use of orlistat is an admission that 'a calorie is a calorie, is a calorie' can't be true. Our body is reliant on the use of enzymes and hormones for digestion. It is therefore naive to think that all foods are digested with equal efficiency.

Focussing on eating foods with a low caloric content does not address the key issues of appetite control, and blood sugar control, which are essential for the prevention of obesity.

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Tips for weight loss

  • Set realistic weight loss goals – aim for 5-10kg (11-22lb) over three months. This is around 0.5kg (1.1lb) a week, but reduce this target if it seems too difficult.
  • Eat regular meals and try reducing the size of your portions.
  • Contact a local slimming club if you think this may help you.
  • Tell your friends and family that you are trying to lose weight, as they can help motivate you.
  • Drink less alcohol, as it is high in calories. 
  • Consider using a food diary to keep track of the amount of calories you are eating, and the changes you are making to your diet.

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