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Taking pioglitazone with other medicines and herbal supplements

Cautions with other medicines

Some medicines affect the way pioglitazone works. Your doctor may need to adjust your dose of pioglitazone. They may also recommend checking your blood sugar levels more often.

Tell your doctor if you're taking any of these medicines before starting to take pioglitazone:

  • gemfibrozil, a medicine used to reduce cholesterol
  • rifampicin, an antibiotic used to treat tuberculosis (TB)

Taking pioglitazone with painkillers

It's safe to take paracetamol with pioglitazone.

Check with your doctor or pharmacist before taking ibuprofen with pioglitazone. This is particularly important if you have heart problems or if you're at risk of getting heart problems.

Mixing pioglitazone with herbal remedies and supplements

There's not enough information to say that herbal remedies or supplements are safe to take with pioglitazone. They're not tested in the same way as pharmacy and prescription medicines. They're generally not tested for the effect they have on other medicines.

Important: Medicine safety

Tell your doctor or pharmacist if you're taking any other medicines, including herbal remedies, vitamins or supplements.

Page last reviewed: 14 March 2022
Next review due: 14 March 2025