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About sitagliptin

Sitagliptin is a medicine used to treat type 2 diabetes.

Type 2 diabetes is a condition where the body does not make enough insulin, or the insulin that it makes does not work properly. This can cause high blood sugar levels (hyperglycaemia).

Sitagliptin is prescribed for people who still have high blood sugar, even though they have a sensible diet and exercise regularly.

It works by increasing the amount of insulin that your body makes. Insulin is the hormone that controls sugar levels in your blood.

Sitagliptin is only available on prescription. It comes as tablets.

It also comes as tablets containing a mixture of sitagliptin and another diabetes medicine called metformin. This is known by the brand name Janumet.

Key facts

  • Sitagliptin starts to work within a few hours. You need to take it every day to make sure your blood sugar stays as stable as possible.
  • You take sitagliptin once a day.
  • The most common side effect of sitagliptin is headaches.
  • This medicine does not usually make you put on weight.
  • If you have diabetes, you're entitled to free prescriptions for all of your medicines, not just your diabetes ones.

Page last reviewed: 11 February 2022
Next review due: 11 February 2025