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Madopar (Madopar 50mg/12.5mg capsules)

Side effects

Information specific to: Madopar 50mg/12.5mg capsules when used in Parkinson's disease.


A medicine is only made available to the public if the clinical trials have shown that the benefits of taking the medicine outweigh the risks.

Once a medicine has been licensed, information on the medicine's effects, both intended and unintended, is continuously recorded and updated.

Some side-effects may be serious while others may only be a mild inconvenience.

Everyone's reaction to a medicine is different. It is difficult to predict which side-effects you will have from taking a particular medicine, or whether you will have any side-effects at all. The important thing is to tell your prescriber or pharmacist if you are having problems with your medicine.

The frequency of these side-effects is unknown

  • a drop in blood pressure on standing or sitting up
  • abnormal laboratory test results
  • abnormal muscle movements or problems controlling muscle movement - this may affect the arms, legs, face or other body parts
  • aggressive behaviour
  • behavioural changes such as an urge to gamble, to buy or to shop, increased libido, hypersexuality, an unusual increase in appetite or binge eating. You or your carer should seek medical advice if there are any changes to your behaviour
  • blood problems
  • delusions
  • depression
  • difficulty sleeping
  • dopamine dysregulation syndrome - this may lead to excessive use of Madopar
  • dose tolerance when Madopar has been taken for a long time - this may lead to periods of time where movement suddenly becomes difficult, where your symptoms return before you take your next dose of Madopar or sudden changes from good symptom control to poor symptom control
  • euphoria
  • feeling agitated
  • feeling anxious
  • feeling drowsy
  • feelings of disorientation
  • flushing
  • gastrointestinal bleeding
  • gastrointestinal problems such as nausea, vomiting, diarrhoea or a loss of appetite - you may reduce the chances of these side-effects from happening by taking Madopar with some food or liquid
  • hallucinations
  • heart problems
  • hypersensitivity reactions
  • itching
  • loss of taste or taste changes
  • may affect the results for certain tests
  • mouth colour changes including the tongue, tooth or saliva
  • neuroleptic malignant syndrome may occur when this medicine is stopped abruptly - seek immediate medical advice if you have fever, muscle rigidity or psychological changes
  • psychiatric problems
  • psychosis or psychotic-like behaviour
  • restless legs syndrome - this may happen if Madopar is taken for a long period of time
  • skin rash or rashes
  • sleepiness - this may be excessive or occur very suddenly at any time of the day. If this happens you must seek medical advice
  • sweating
  • urine colour changes - this may include the urine becoming red in colour

If you feel unwell or if you have concerns about a side-effect, you will need to seek advice. If you feel very ill, get medical help straight away. Contact your prescriber, pharmacist, nurse or call 111.

Content provided by Datapharm

Yellow Card scheme

The Yellow card Scheme is vital in helping the MHRA monitor the safety of the medicines and vaccines that are on the market.

Before a medicine is granted a licence so that it can be made available in the United Kingdom, it must pass strict tests and checks to ensure that it is acceptably safe and effective. All effective medicines however, can cause side effects.