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Solpadeine Migraine ibuprofen and codeine tablets

  • Overview


Information specific to: Solpadeine Migraine ibuprofen and codeine tablets.

About Solpadeine Migraine ibuprofen and codeine tablets and how it works

This medicine helps relieve mild to moderate pain and aches such as headache, migraine, toothache, period pain, backache, or nerve pain; and pain and inflammation caused by rheumatism or mild arthritic conditions which is not relieved by the usual painkillers paracetamol, ibuprofen or aspirin alone. It contains two main pain-killers: ibuprofen and codeine. Ibuprofen belongs to a class of medicines called Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) and works by blocking the production of some chemicals in the body that cause inflammation, pain and fever. Codeine belongs to a class of medicines called opioid analgesics and relieves pain by helping to reduce the brain's awareness of pain impulses.

This medicine is available as tablets that are taken by mouth. It is best to take this medicine with or after food.

Do not take more than six tablets in 24 hours and leave a gap of at least four hours between doses.

This medicine contains codeine which is addictive and must not be taken for more than three days without medical advice. You may get withdrawal symptoms from the medicine when you stop taking it. It can also make your existing headache worse if taken for a long period of time.

Consult your doctor if you have a persistent headache or if your symptoms do not improve after three days, or if they get worse during treatment with this medicine.

Before using Solpadeine Migraine ibuprofen and codeine tablets

This medicine may not be suitable for everyone and some people must never take it. Check the leaflet that comes with your medicine to make sure that the medicine is suitable before taking it.

Always get advice from a healthcare professional before taking this medicine if:

  • you are allergic or sensitive to or have had a reaction to the medicines ibuprofen or codeine or any of the ingredients in the medicine
  • you have had hypersensitivity reactions in the past such as rhinitis, angioedema or urticaria after taking aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs)
  • this medicine is for a child under 12 years of age
  • you have or have had gastro-intestinal bleeding or perforation in the past after taking non-steroidal anti-inflammatory drugs (NSAIDs)
  • you have or have had a peptic ulcer
  • you have or have had asthma or allergic diseases
  • you have an auto-immune disorder such as systemic lupus erythematosus or mixed connective tissue disease
  • you have liver problems
  • you have kidney problems
  • you have or have had high blood pressure
  • you have or have had gastrointestinal problems
  • you have had a cholecystectomy
  • you have bowel problems such as ulcerative colitis or Crohn’s disease
  • you are elderly
  • you have or have had heart and circulation problems
  • you have or have had a stroke
  • you have high levels of cholesterol in your blood
  • you smoke
  • you have galactose intolerance
  • you have Lapp lactase deficiency
  • you have glucose-galactose malabsorption
  • you have problems metabolising medicines
  • you have been told that you liver converts codeine into morphine rapidly
  • you are under 18 years of age and have had your tonsils or adenoids removed because of obstructive sleep apnoea syndrome
  • this medicine is for a child with a compromised respiratory function including lung problems, neuromuscular disorders, heart problems, infections of the upper respiratory tract, major surgery or multiple trauma

Medicines interactions

If you are taking more than one medicine they may interact with each other. Before taking this medicine consult your doctor or pharmacist if you are taking or have recently taken any other medicines including vitamins, supplements and herbal or complementary preparations.

The following medicines may interact with this medicine:

  • monoamine oxidase inhibitors - do not take this medicine if you are currently taking these medicines or have taken them within the last 14 days
  • aspirin
  • other NSAIDs including cyclo-oxygenase-2 selective inhibitors
  • anti-coagulants such as warfarin
  • diuretics
  • antihypertensives
  • medicines that cause bleeding or other gastrointestinal effects such as corticosteroids, antiplatelets or selective serotonin-reuptake inhibitors (SSRIs)
  • lithium
  • methotrexate
  • zidovudine
  • aminoglycosides
  • cardiac glycosides
  • central nervous system depressants including anaesthetics , hypnotics , sedatives , tricyclic antidepressants and psychotics such as phenothiazines
  • domperidone
  • sulfonylureas
  • metoclopramide
  • ciclosporin
  • mifepristone
  • tacrolimus
  • quinolone antibiotics

Possible side effects of Solpadeine Migraine ibuprofen and codeine tablets

Most medicines can cause some side-effects but not everyone having the same medicine will get the same side-effects.

The following side-effects have been associated with people taking this medicine:

  • hypersensitivity reactions including allergic reactions, asthma, bronchospasm, low blood pressure, anaphylaxis or shock. Stop taking this medicine and seek immediate medical help if your face, tongue or throat swell, you have breathing difficulties or your heart rate is fast
  • gastro-intestinal bleeding, ulceration or perforation - these could be fatal. Stop taking this medicine and seek immediate medical advice if you have unusual stomach pain, discomfort, or have signs of gastro-intestinal bleeding such as vomiting blood or blood in stools
  • skin problems such as Stevens-Johnson Syndrome, erythema multiforme or toxic epidermal necrolysis. Stop taking this medicine and seek immediate medical advice if you get skin reactions such as urticaria, itching or skin rashes
  • aseptic meningitis - this has been reported in people who have autoimmune disorders such as systemic lupus erythematosus or mixed connective tissue disease. Seek immediate medical advice if you get symptoms such as a stiff neck, headache, nausea, vomiting, fever or are disorientated
  • blood and bone marrow problems - seek medical advice if you get symptoms such as fever, sore throat, mouth ulcers, flu-like symptoms, feel very tired or have unexplained bleeding and bruising
  • long-term use of codeine containing medicines may lead to addiction and withdrawal symptoms such as restlessness or irritability when the medicine is stopped
  • headache - long-term use of a painkiller for headaches can make them worse
  • worsening of asthma and bronchospasm
  • stomach pain
  • acute pancreatitis - this may happen in people who have had their gallbladder removed and take this medicine
  • nausea
  • drowsiness
  • indigestion
  • diarrhoea
  • flatulence
  • constipation
  • vomiting
  • ulcerative stomatitis
  • gastritis
  • worsening of ulcerative colitis or Crohn’s disease
  • dizziness
  • kidney problems or worsening of existing kidney problems
  • liver problems
  • hearing problems
  • high blood pressure
  • heart problems such as heart failure
  • thromboembolic events such as a stroke or heart attack
  • oedema
  • fluid retention
  • impaired female fertility
  • dry mouth
  • sweating

If you experience other side effects or have any other worrying symptoms while you are taking this medicine, seek medical advice.

Pregnancy and breast-feeding

Do not take this medicine if you are trying to become pregnant, are pregnant, or are breast-feeding.

Other important information

Make sure that you read the leaflet that comes with your medicine to check what dose you should take and if there is anything that you need to do if you take more than the recommended dose. If you are in any doubt about whether this medicine is suitable for you, speak to your doctor or pharmacist.

This medicine may affect your ability to drive or operate machinery. Do not drive or operate machinery until you know how this medicine affects you.

This medicine may interact with alcohol. It is best to avoid alcoholic drinks while you are taking this medicine.

Keep all medicines out of the sight and reach of children.

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