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Canesten Oral And Cream Duo

  • Overview


Information specific to: Canesten Oral And Cream Duo.

About Canesten Oral And Cream Duo and how it works

This combination of Fluconazole and Clotrimazole is used to treat vaginal or penile thrush.

This medicine consists of two items: a capsule containing fluconazole and a cream containing clotrimazole. These ingredients are both antifungals and are used together to treat fungal infections. The fluconazole capsule treats the main infection and the clotrimazole cream helps relieve the superficial symptoms such as itching and soreness.

The capsule in the pack is to be taken by mouth. You should swallow it whole with a glass of water. It can be taken with or without food.

The cream is for external use and needs to be applied on the genitals two or three times a day.

Women should apply the cream until symptoms of the infection disappear but should speak to a doctor if their symptoms get worse or do not improve within seven days of having the capsule.

Male sexual partners who are being treated with the cream may use it for up to two weeks but should speak to their doctor if their symptoms get worse or do not improve within seven days.

Before using Canesten Oral And Cream Duo

This medicine may not be suitable for everyone and some people must never have it. Check the leaflet that comes with your medicine to make sure that the medicine is suitable before having it.

Always get advice from a healthcare professional before having this medicine if:

  • you are allergic or sensitive to or have had a reaction to fluconazole, clotrimazole or any of the ingredients in either of the medicines or to imidazole antifungals
  • this medicine is for someone under 16 years of age or over 60 years of age
  • you are not sure if you have thrush and this is the first time you have had these symptoms
  • you have had more than two infections of thrush in the last six months
  • you or your partner have a history of a sexually transmitted disease
  • you have liver problems
  • you have kidney problems
  • you have pain or difficulty in passing urine
  • you have had unexplained jaundice
  • you have or have had heart problems including heart rhythm problems
  • you have a long standing illness or disease
  • you have a family history of galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption
  • you are taking other medicines
  • you are a female and any one of the following apply:
  • you are a male and any one of the following apply:
    • you have had an allergy or sensitivity to vaginal antifungal products
    • you have irregular vaginal bleeding
    • you have abnormal vaginal bleeding or a blood stained discharge
    • you have ulcers, blisters or sores on the vagina or vulva
    • you have lower abdominal pain
    • you have a burning sensation when passing urine
    • you have fever or chills
    • you are feeling sick or vomiting
    • you have diarrhoea
    • you have a foul smelling discharge from the vagina
    • your sexual partner does not have thrush
    • you have abnormal discharge from your penis
    • you have ulcers, blisters or sores on your penis
    • your penis smells
    • you have pain or difficulty in passing urine

Medicines interactions

If you are taking or using more than one medicine they may interact with each other. Before taking this medicine consult your doctor or pharmacist if you are taking or have recently taken any other medicines including vitamins, supplements and herbal or complementary preparations.

The following medicines may interact with this medicine:

  • antihistamines such as terfenadine
  • ergot derivatives such as dihydroergotamine, ergoloid mesylates, ergonovine, ergotamine, methylergonovine, methysergide
  • carbamazepine
  • phenobarbital
  • rifapentine
  • sirolimus
  • losartan
  • fentanyl
  • methadone
  • cisapride
  • anticoagulants such as warfarin
  • sulphonylureas such as chlorpropamide, glibenclamide, glipizide and tolbutamide
  • hydrochlorothiazide
  • benzodiazepines such as midazolam
  • phenytoin
  • rifampicin
  • rifabutin
  • ciclosporin
  • tacrolimus
  • theophylline
  • zidovudine
  • anti-arrhythmics
  • medicines metabolised by the cytochrome P450 system such as astemizole

Possible side effects of Canesten Oral And Cream Duo

Most medicines can cause some side-effects but not everyone having the same medicine will get the same side-effects.

The following side-effects have been associated with people having this medicine:

  • allergic reactions, anaphylaxis and shock to the capsule or to the cream may occur - seek immediate medical advice if you get any of the following symptoms:
  • feeling sick or vomiting
  • taste changes
  • stomach distension, pain and discomfort
  • diarrhoea
  • wind
  • headaches
  • heart rhythm problems
  • abnormal ECG (electrocardiogram) heart tracing
  • high blood cholesterol and triglyceride levels
  • blood problems
  • low levels of potassium
  • liver problems with symptoms such as abnormal liver test results, yellowing of the skin or eyes, dark urine or pale stools - some of these liver problems can be fatal
  • skin reactions including dermatitis, discomfort, urticaria, oedema, redness, peeling of the skin, stinging, irritation, blistering of the skin, mouth, eyes or genitals, toxic epidermal necrolysis, and Stevens-Johnson syndrome
  • seizures
  • hair loss
  • recurrent infection such as colds and flu
    • a rash
    • swallowing or breathing problems
    • swelling of the lips, face, throat or tongue
    • weakness, lowering of blood pressure and feeling dizzy or faint
    • nausea
    • worsening of pain, burning sensations, swelling, itching or redness of the skin

If you experience other side effects or have any other worrying symptoms while you are using this medicine, seek medical advice.

Pregnancy and breast-feeding

Do not have this medicine if you are trying to become pregnant, are pregnant or are breast-feeding.

Other important information

Make sure that you read the leaflet that comes with your medicine to check what dose you should have and if there is anything that you need to do if you have more than the recommended dose. If you are in any doubt about whether this medicine is suitable for you, speak to your doctor or pharmacist.

The clotrimazole cream in this medicine pack may make rubber contraceptives such as condoms and diaphragms less effective. It is best you take other precautions for at least five days after using the cream.

The oral capsule may cause dizziness and affect your ability to drive or operate machinery. Do not drive or operate machinery until you know how this medicine affects you.

Keep all medicines out of the sight and reach of children.

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