Can you help us improve NHS Choices?

Take part in our survey to share your views

Sulpiride (Sulpiride 200mg tablets)



Information specific to: Sulpiride 200mg tablets when used in Schizophrenia and Psychosis.

Sulpiride (Sull-peer-ride) is a medicine which is used in schizophrenia.

The information in this Medicine Guide for Sulpiride varies according to the condition being treated and the particular preparation used.

Your medicine

Sulpiride blocks some of the effects of certain chemicals in the brain which are thought to affect thinking, feelings and behaviour. This can help to treat the symptoms of schizophrenia.

Do not share your medicine with other people. It may not be suitable for them and may harm them.

The pharmacy label on your medicine tells you how much medicine you should take. It also tells you how often you should take your medicine. This is the dose that you and your prescriber have agreed you should take. You should not change the dose of your medicine unless you are told to do so by your prescriber.

If you feel that the medicine is making you unwell or you do not think it is working, then talk to your prescriber.

Whether this medicine is suitable for you

Sulpiride is not suitable for everyone and some people should never use it. Other people should only use it with special care. It is important that the person prescribing this medicine knows your full medical history.

Your prescriber may only prescribe this medicine with special care or may not prescribe it at all if you:

  • are allergic or sensitive to or have had a reaction to any of the ingredients in the medicine
  • are elderly
  • have a tumour that is sensitive to hormones
  • have cerebrovascular problems
  • have certain types of heart or circulation problems
  • have dementia
  • have had a stroke or have risk factors for a stroke
  • have kidney problems
  • have mania
  • have metabolic problems
  • have or have had epilepsy
  • have or have risk factors for thromboembolic problems
  • have Parkinson's disease
  • have phaeochromocytoma
  • have porphyria

Furthermore the prescriber may only prescribe this medicine with special care or may not prescribe it at all for someone who is under 14 years of age.

As part of the process of assessing suitability to take this medicine a prescriber may also arrange tests:

  • to determine whether or not the medicine is suitable and whether it must be prescribed with extra care
  • to check that this medicine is not having any undesired effects

Over time it is possible that Sulpiride can become unsuitable for some people, or they may become unsuitable for it. If at any time it appears that Sulpiride has become unsuitable, it is important that the prescriber is contacted immediately.


Alcohol can interact with certain medicines.

In the case of Sulpiride:

  • alcohol may increase the effects of this medicine

You must not drink any alcohol if you are taking this medicine.


Medicines can interact with certain foods. In some cases, this may be harmful and your prescriber may advise you to avoid certain foods.

In the case of Sulpiride:

  • there are no specific foods that you must exclude from your diet when taking Sulpiride

Driving and operating machinery

When taking any medicine you should be aware that it might interfere with your ability to drive or operate machinery safely.

In the case of Sulpiride:

  • this medicine could affect your ability to drive or operate machinery

You should see how this medicine affects you before you judge whether you are safe to drive or operate machinery. If you are in any doubt about whether you should drive or operate machinery, talk to your prescriber.

Family planning and pregnancy

Most medicines, in some way, can affect the development of a baby in the womb. The effect on the baby differs between medicines and also depends on the stage of pregnancy that you have reached when you take the medicine.

In the case of Sulpiride:

  • the use of this medicine during pregnancy is not recommended
  • if you take this medicine during the late stages of pregnancy, your baby may have some problems or withdrawal symptoms from Sulpiride and may need to have some monitoring after birth

You should discuss your personal circumstances with your doctor if you are pregnant or want to become pregnant. This is so that together you can make a decision about what treatment you may need during your pregnancy.

You should discuss whether there are any other medicines which you could take during pregnancy which would treat your condition.


Certain medicines can pass into breast milk and may reach your baby through breast-feeding.

In the case of Sulpiride:

  • breast-feeding is not recommended while taking this medicine

Before you have your baby you should discuss breast-feeding with your doctor or midwife. They will help you decide what is best for you and your baby based on the benefits and risks associated with this medicine. If you wish to breast-feed you should discuss with your prescriber whether there are any other medicines you could take which would also allow you to breast-feed. You should not stop this medicine without taking advice from your doctor.

Taking other medicines

If you are taking more than one medicine they may interact with each other. At times your prescriber may decide to use medicines that interact, in other cases this may not be appropriate.

The decision to use medicines that interact depends on your specific circumstances. Your prescriber may decide to use medicines that interact, if it is believed that the benefits of taking the medicines together outweigh the risks. In such cases, it may be necessary to alter your dose or monitor you more closely.

Tell your prescriber the names of all the medicines that you are taking so that they can consider all possible interactions. This includes all the medicines which have been prescribed by your GP, hospital doctor, dentist, nurse, health visitor, midwife or pharmacist. You must also tell your prescriber about medicines which you have bought over the counter without prescriptions.

The following medicines may interact with Sulpiride:

  • amiodarone
  • amphotericin B when injected into a vein
  • cisapride
  • clonidine
  • diltiazem
  • disopyramide
  • erythromycin when injected into a vein
  • halofantrine
  • haloperidol
  • imipramine
  • levodopa
  • lithium
  • methadone
  • pentamidine
  • pimozide
  • quinidine
  • ropinirole
  • sotalol
  • sucralfate
  • tetracosactide
  • thioridazine
  • verapamil

The following types of medicine may interact with Sulpiride:

  • analgesics
  • antacids
  • antiarrhythmics
  • antihypertensives
  • anxiolytics
  • barbiturates
  • benzodiazepines
  • beta-blockers
  • calcium channel blockers
  • clonidine derivatives
  • digitalis glycosides
  • glucocorticosteroids
  • medicines that affect electrolyte balance
  • medicines that lower blood pressure
  • medicines that prolong the QTc interval
  • medicines that reduce heart rate
  • medicines which depress the CNS
  • narcotics
  • other antipsychotics
  • potassium depleting medicines
  • sedative antihistamines
  • stimulant laxatives
  • tricyclic antidepressants

If you are taking Sulpiride and one of the above medicines or types of medicines, make sure your prescriber knows about it.

Complementary preparations and vitamins

Medicines can interact with complementary preparations and vitamins. In general, there is not much information available about interactions between medicines and complementary preparations or vitamins.

If you are planning to take or are already taking any complementary preparations and vitamins you should ask your prescriber whether there are any known interactions with Sulpiride.

Your prescriber can advise whether it is appropriate for you to take combinations that are known to interact. They can also discuss with you the possible effect that the complementary preparations and vitamins may have on your condition.

If you experience any unusual effects while taking this medicine in combination with complementary preparations and vitamins, you should tell your prescriber.

Content provided by Datapharm

Printable guides available for this medicine: