Protamine (Protamine sulphate 50mg/5ml solution for injection ampoules)



Information specific to: Protamine sulphate 50mg/5ml solution for injection ampoules when used in Heparin overdose.

Protamine (Proh-tam-een sul-fate) is a medicine which is used in blocking the effects of heparin.

The information in this Medicine Guide for Protamine varies according to the condition being treated and the particular preparation used.

Your medicine

Protamine sulphate is used to stop the effects of a medicine called heparin. Heparin is used to prevent blood from clotting but too much heparin can increase the risks of serious bleeding. Protamine sulphate reduces the risk of serious bleeding by stopping the effect of heparin on the blood.

Protamine sulphate is usually given to you by a healthcare professional. The person responsible for giving you your medicine will make sure that you get the right dose.

If you feel that the medicine is making you unwell or you do not think it is working, then talk to your prescriber or someone involved in your medical care.

Whether this medicine is suitable for you

Protamine sulphate is not suitable for everyone and some people should never use it. Other people should only use it with special care. It is important that the person prescribing this medicine knows your full medical history.

Your prescriber may only prescribe this medicine with special care or may not prescribe it at all if you:

  • are allergic or sensitive to or have had a reaction to any of the ingredients in the medicine
  • are allergic to fish
  • are male and are infertile or have had a vasectomy
  • have diabetes that is controlled by insulin
  • have had a recent heart procedure or recent heart surgery

Furthermore the prescriber may only prescribe this medicine with special care or may not prescribe it at all for a child.

As part of the process of assessing suitability to take this medicine a prescriber may also arrange tests:

  • to check that this medicine is having the desired effect
  • to check that this medicine is not having any undesired effects

Over time it is possible that Protamine sulphate can become unsuitable for some people, or they may become unsuitable for it. If at any time it appears that Protamine sulphate has become unsuitable, it is important that the prescriber is contacted immediately.


In the case of Protamine sulphate:

  • there are no known interactions between alcohol and Protamine sulphate


Medicines can interact with certain foods. In some cases, this may be harmful and your prescriber may advise you to avoid certain foods.

In the case of Protamine sulphate:

  • there are no specific foods that you must exclude from your diet when having Protamine sulphate

Driving and operating machinery

When taking any medicine you should be aware that it might interfere with your ability to drive or operate machinery safely.

Like all medicines Protamine sulphate can cause side effects. You should see how this medicine affects you and then judge if you are safe to drive or operate machinery. If you are in any doubt, talk to your prescriber.

Family planning and pregnancy

Most medicines, in some way, can affect the development of a baby in the womb. The effect on the baby differs between medicines and also depends on the stage of pregnancy that you have reached when you take the medicine.

In the case of Protamine sulphate:

  • you should only have this medicine during pregnancy if your doctor thinks that you need it

You need to discuss your specific circumstances with your doctor to weigh up the overall risks and benefits of taking this medicine. You and your doctor can make a decision about whether you are going to take this medicine during pregnancy.

If the decision is that you should not have Protamine sulphate, then you should discuss whether there is an alternative medicine that you could take during pregnancy.


Certain medicines can pass into breast milk and may reach your baby through breast-feeding.

In the case of Protamine sulphate:

  • you should only have this medicine while breast-feeding if your doctor thinks you need it

Before you have your baby you should discuss breast-feeding with your doctor or midwife. They will help you decide what is best for you and your baby based on the benefits and risks associated with this medicine. You should only breast-feed your baby while taking this medicine on the advice of your doctor or midwife.

Taking other medicines

There are no known important interactions between Protamine sulphate and other medicines. If you experience any unusual symptoms while having Protamine sulphate and other medicines you should tell your prescriber.

Complementary preparations and vitamins

Medicines can interact with complementary preparations and vitamins. In general, there is not much information available about interactions between medicines and complementary preparations or vitamins.

If you are planning to take or are already taking any complementary preparations and vitamins you should ask your prescriber whether there are any known interactions with Protamine sulphate.

Your prescriber can advise whether it is appropriate for you to take combinations that are known to interact. They can also discuss with you the possible effect that the complementary preparations and vitamins may have on your condition.

If you experience any unusual effects while taking this medicine in combination with complementary preparations and vitamins, you should tell your prescriber.

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