Fluconazole (Fluconazole 200mg capsules)

 

Overview

Information specific to: Fluconazole 200mg capsules when used in Fungal infections.

Fluconazole (Floo-con-az-ol) is a medicine which is used in certain types of fungal infections.

The information in this Medicine Guide for Fluconazole varies according to the condition being treated and the particular preparation used.

Your medicine

Fluconazole works by killing certain types of fungi. It is used to treat many types of fungal infections. Fluconazole can also be used to prevent fungal infections in people whose immune system is not working properly.

Do not share your medicine with other people. It may not be suitable for them and may harm them.

The pharmacy label on your medicine tells you how much medicine you should take. It also tells you how often you should take your medicine. This is the dose that you and your prescriber have agreed you should take. You should not change the dose of your medicine unless you are told to do so by your prescriber.

If you feel that the medicine is making you unwell or you do not think it is working, then talk to your prescriber.

Whether this medicine is suitable for you

Fluconazole is not suitable for everyone and some people should never use it. Other people should only use it with special care. It is important that the person prescribing this medicine knows your full medical history.

Your prescriber may only prescribe this medicine with special care or may not prescribe it at all if you:

  • are allergic or sensitive to or have had a bad reaction to azoles in the past
  • are allergic or sensitive to or have had a reaction to any of the ingredients in the medicine
  • are on haemodialysis
  • are seriously ill or are having serious underlying medical conditions
  • have AIDS
  • have kidney problems
  • have liver problems
  • have metabolic problems
  • have or have risk factors for certain types of heart problems

Furthermore the prescriber may only prescribe this medicine with special care or may not prescribe it at all for a fungalinfection of the genitals of someone who is under 17 years of age.

As part of the process of assessing suitability to take this medicine a prescriber may also arrange tests:

  • to check that this medicine is having the desired effect
  • to check that this medicine is not having any undesired effects
  • to determine whether or not the medicine is suitable and whether it must be prescribed with extra care

Over time it is possible that Fluconazole can become unsuitable for some people, or they may become unsuitable for it. If at any time it appears that Fluconazole has become unsuitable, it is important that the prescriber is contacted immediately.

Alcohol

Alcohol can interact with certain medicines.

In the case of Fluconazole:

  • there are no known interactions between alcohol and Fluconazole

Diet

Medicines can interact with certain foods. In some cases, this may be harmful and your prescriber may advise you to avoid certain foods.

In the case of Fluconazole:

  • there are no specific foods that you must exclude from your diet when taking Fluconazole

Driving and operating machinery

When taking any medicine you should be aware that it might interfere with your ability to drive or operate machinery safely.

In the case of Fluconazole:

  • this medicine could affect your ability to drive or operate machinery

You should see how this medicine affects you before you judge whether you are safe to drive or operate machinery. If you are in any doubt about whether you should drive or operate machinery, talk to your prescriber.

Family planning and pregnancy

Most medicines, in some way, can affect the development of a baby in the womb. The effect on the baby differs between medicines and also depends on the stage of pregnancy that you have reached when you take the medicine.

In the case of Fluconazole:

  • you should only take this medicine during pregnancy if your doctor thinks that you need it
  • taking this medicine during pregnancy may harm your baby. This can happen if it is taken for long periods of time or if it is taken repeatedly

You need to discuss your specific circumstances with your doctor to weigh up the overall risks and benefits of taking this medicine. You and your doctor can make a decision about whether you are going to take this medicine during pregnancy.

If the decision is that you should not have Fluconazole, then you should discuss whether there is an alternative medicine that you could take during pregnancy.

Breast-feeding

Certain medicines can pass into breast milk and may reach your baby through breast-feeding.

In the case of Fluconazole:

  • breast-feeding is not recommended while taking this medicine

Before you have your baby you should discuss breast-feeding with your doctor or midwife. If you wish to breast-feed you should discuss with your prescriber whether there are any other medicines you could take which would also allow you to breast-feed. You should not stop this medicine without taking advice from your doctor.

Taking other medicines

If you are taking more than one medicine they may interact with each other. At times your prescriber may decide to use medicines that interact, in other cases this may not be appropriate.

The decision to use medicines that interact depends on your specific circumstances. Your prescriber may decide to use medicines that interact, if it is believed that the benefits of taking the medicines together outweigh the risks. In such cases, it may be necessary to alter your dose or monitor you more closely.

Tell your prescriber the names of all the medicines that you are taking so that they can consider all possible interactions. This includes all the medicines which have been prescribed by your GP, hospital doctor, dentist, nurse, health visitor, midwife or pharmacist. You must also tell your prescriber about medicines which you have bought over the counter without prescriptions.

The following medicines may interact with Fluconazole:

  • alfentanil
  • amitriptyline
  • amlodipine
  • amphotericin B
  • astemizole
  • atorvastatin
  • carbamazepine
  • celecoxib
  • chlorpropamide
  • ciclosporin
  • cisapride
  • cyclophosphamide
  • diclofenac
  • erythromycin
  • ethinylestradiol
  • everolimus
  • felodipine
  • fentanyl
  • flurbiprofen
  • fluvastatin
  • glibenclamide
  • glipizide
  • halofantrine
  • ibuprofen
  • isradipine
  • levonorgestrel
  • lornoxicam
  • losartan
  • meloxicam
  • methadone
  • midazolam
  • naproxen
  • nifedipine
  • nortriptyline
  • phenytoin
  • pimozide
  • prednisone
  • quinidine
  • rifabutin
  • rifampicin
  • saquinavir
  • saquinavir/ritonavir
  • simvastatin
  • sirolimus
  • tacrolimus
  • terfenadine
  • theophylline
  • tolbutamide
  • triazolam
  • verapamil
  • vinblastine
  • vincristine
  • vitamin A
  • voriconazole
  • warfarin
  • zidovudine

The following types of medicine may interact with Fluconazole:

  • benzodiazepines
  • calcium channel blockers
  • coumarin anticoagulants
  • cytochrome P450 enzyme inhibitors
  • HMG-CoA reductase inhibitors
  • immunosuppressant medicines
  • medicines that are metabolised by the cytochrome P450 system
  • medicines that prolong the QTc interval
  • non-steroidal anti-inflammatories
  • oral contraceptives
  • oral sulphonylureas
  • p-glycoprotein inhibitors
  • vinca alkaloids

If you are taking Fluconazole and one of the above medicines or types of medicines, make sure your prescriber knows about it.

Complementary preparations and vitamins

Medicines can interact with complementary preparations and vitamins.

Make sure you tell your prescriber the names of all the complementary preparations and vitamins that you are taking or are planning to take.

Your prescriber can then decide whether it is appropriate for you to take combinations that are known to interact.

In the case of Fluconazole:

  • this medicine may interact with vitamin A

If you have been prescribed Fluconazole you should only take something on the above list on the specific advice of your prescriber or pharmacist.

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