Rivotril (Rivotril 2mg tablets)



Information specific to: Rivotril 2mg tablets when used in Epilepsy.

Rivotril (Riv-oh-tril) is a medicine which is used in all forms of epilepsy. Rivotril contains clonazepam. It is supplied by Roche Products Limited.

The information in this Medicine Guide for Rivotril varies according to the condition being treated and the particular preparation used.

Your medicine

Rivotril is used to treat epilepsy. People with epilepsy are prone to having periods of uncontrolled electrical activity in the brain. These periods of uncontrolled electrical activity may lead to seizures. Rivotril helps to control electrical activity in the brain. This reduces the chances of having seizures.

Rivotril can also be given by injection to help stop a seizure which has already started.

Rivotril can cause tolerance, dependence and even withdrawal symptoms in some people and you must never stop taking it suddenly. If you need to stop taking Rivotril then it must be stopped gradually.

Other information about Rivotril:

  • your doctor may start you on a low dose of this medicine and then increase the dose depending on how you respond to treatment

Do not share your medicine with other people. It may not be suitable for them and may harm them.

The pharmacy label on your medicine tells you how much medicine you should take. It also tells you how often you should take your medicine. This is the dose that you and your prescriber have agreed you should take. You should not change the dose of your medicine unless you are told to do so by your prescriber.

If you feel that the medicine is making you unwell or you do not think it is working, then talk to your prescriber.

Whether this medicine is suitable for you

Rivotril is not suitable for everyone and some people should never use it. Other people should only use it with special care. It is important that the person prescribing this medicine knows your full medical history.

Your prescriber may only prescribe this medicine with special care or may not prescribe it at all if you:

  • are allergic or sensitive to or have had a bad reaction to benzodiazepines in the past
  • are allergic or sensitive to or have had a reaction to any of the ingredients in the medicine
  • are debilitated
  • are elderly
  • are in a coma
  • are intoxicated with drugs or alcohol
  • have abused alcohol in the past
  • have ataxia
  • have attempted suicide
  • have galactose intolerance
  • have glucose-galactose malabsorption problems
  • have had a recent loss or bereavement
  • have kidney problems
  • have Lapp lactase deficiency
  • have liver problems
  • have lung or breathing problems such as chronic obstructive pulmonary disease
  • have misused drugs in the past
  • have myasthenia gravis
  • have or have had depression
  • have porphyria
  • have sleep apnoea syndrome

Over time it is possible that Rivotril can become unsuitable for some people, or they may become unsuitable for it. If at any time it appears that Rivotril has become unsuitable, it is important that the prescriber is contacted immediately.


Alcohol can interact with certain medicines.

In the case of Rivotril:

  • this medicine may interact with alcohol

You must not drink any alcohol if you are taking this medicine.


Medicines can interact with certain foods. In some cases, this may be harmful and your prescriber may advise you to avoid certain foods.

In the case of Rivotril:

  • there are no specific foods that you must exclude from your diet when taking Rivotril

Driving and operating machinery

When taking any medicine you should be aware that it might interfere with your ability to drive or operate machinery safely.

In the case of Rivotril:

  • this medicine could affect your ability to drive or operate machinery

You should seek advice from your prescriber as to whether you may drive while taking this medicine.

Family planning and pregnancy

Most medicines, in some way, can affect the development of a baby in the womb. The effect on the baby differs between medicines and also depends on the stage of pregnancy that you have reached when you take the medicine.

In the case of Rivotril:

  • if you take this medicine during your pregnancy, your baby may have some problems after birth. Also, if you repeatedly take this medicine during the late stages of pregnancy, your baby may come to be physically dependent on Rivotril. This may lead to your baby having withdrawal symptoms from Rivotril after birth
  • you should only take this medicine during pregnancy if your doctor thinks that you need it

You should discuss your personal circumstances with your doctor if you are pregnant or want to become pregnant. This is so that together you can make a decision about what treatment you may need during your pregnancy.

You should discuss whether there are any other medicines which you could take during pregnancy which would treat your condition.


Certain medicines can pass into breast milk and may reach your baby through breast-feeding.

In the case of Rivotril:

  • women who are taking Rivotril should not breast-feed

Before you have your baby you should discuss breast-feeding with your doctor or midwife. They will help you decide what is best for you and your baby based on the benefits and risks associated with this medicine. If you wish to breast-feed you should discuss with your prescriber whether there are any other medicines you could take which would also allow you to breast-feed. You should not stop this medicine without taking advice from your doctor.

Taking other medicines

If you are taking more than one medicine they may interact with each other. At times your prescriber may decide to use medicines that interact, in other cases this may not be appropriate.

The decision to use medicines that interact depends on your specific circumstances. Your prescriber may decide to use medicines that interact, if it is believed that the benefits of taking the medicines together outweigh the risks. In such cases, it may be necessary to alter your dose or monitor you more closely.

Tell your prescriber the names of all the medicines that you are taking so that they can consider all possible interactions. This includes all the medicines which have been prescribed by your GP, hospital doctor, dentist, nurse, health visitor, midwife or pharmacist. You must also tell your prescriber about medicines which you have bought over the counter without prescriptions.

The following medicines may interact with Rivotril:

  • carbamazepine
  • cimetidine
  • phenobarbital
  • phenytoin
  • primidone
  • rifampicin
  • sodium valproate
  • valproate

The following types of medicine may interact with Rivotril:

  • anaesthetics
  • analgesics
  • antiepileptics
  • hydantoins
  • hypnotics
  • liver enzyme inducers
  • liver enzyme inhibitors
  • medicines that act on the central nervous system
  • medicines which depress the CNS
  • muscle relaxants
  • psychoactive drugs

If you are taking Rivotril and one of the above medicines or types of medicines, make sure your prescriber knows about it.

Complementary preparations and vitamins

Medicines can interact with complementary preparations and vitamins. In general, there is not much information available about interactions between medicines and complementary preparations or vitamins.

If you are planning to take or are already taking any complementary preparations and vitamins you should ask your prescriber whether there are any known interactions with Rivotril.

Your prescriber can advise whether it is appropriate for you to take combinations that are known to interact. They can also discuss with you the possible effect that the complementary preparations and vitamins may have on your condition.

If you experience any unusual effects while taking this medicine in combination with complementary preparations and vitamins, you should tell your prescriber.

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