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Lamotrigine (Lamotrigine 100mg dispersible tablets sugar free)



Information specific to: Lamotrigine 100mg dispersible tablets sugar free when used in Epilepsy.

Lamotrigine (Lam-ot-rij-een) is a medicine which is used in generalised epilepsy, partial epilepsy, bipolar disorder, Lennox-Gastaut syndrome and absence seizures.

The information in this Medicine Guide for lamotrigine varies according to the condition being treated and the particular preparation used.

Your medicine

Lamotrigine is used to treat epilepsy. People with epilepsy are prone to having periods of uncontrolled electrical activity in the brain. These periods of uncontrolled electrical activity may lead to seizures. Lamotrigine helps to control electrical activity in the brain. This reduces the chances of having seizures.

Lamotrigine is also used to treat depressive episodes in people who have bipolar disorder.

Other information about Lamotrigine:

  • your doctor may start you on a low dose of this medicine and then increase the dose depending on how you respond to treatment

Do not share your medicine with other people. It may not be suitable for them and may harm them.

The pharmacy label on your medicine tells you how much medicine you should take. It also tells you how often you should take your medicine. This is the dose that you and your prescriber have agreed you should take. You should not change the dose of your medicine unless you are told to do so by your prescriber.

If you feel that the medicine is making you unwell or you do not think it is working, then talk to your prescriber.

Whether this medicine is suitable for you

Lamotrigine is not suitable for everyone and some people should never use it. Other people should only use it with special care. It is important that the person prescribing this medicine knows your full medical history.

Your prescriber may only prescribe this medicine with special care or may not prescribe it at all if you:

  • are allergic or sensitive to or have had a reaction to any of the ingredients in the medicine
  • have had a rash or an allergic reaction after taking medicines containing Lamotrigine or other antiepileptic medicines
  • have had meningitis caused by previous treatment with Lamotrigine
  • have had Stevens-Johnson syndrome, toxic epidermal necrolysis or skin problems caused by previous treatment with Lamotrigine
  • have kidney problems
  • have liver problems
  • have or have had thoughts of committing suicide
  • have Parkinson's disease

Furthermore the prescriber may only prescribe this medicine with special care or may not prescribe it at all for a child who is under two years of age.

Over time it is possible that Lamotrigine can become unsuitable for some people, or they may become unsuitable for it. If at any time it appears that Lamotrigine has become unsuitable, it is important that the prescriber is contacted immediately.


Alcohol can interact with certain medicines.

In the case of Lamotrigine:

  • there are no known interactions between alcohol and Lamotrigine


Medicines can interact with certain foods. In some cases, this may be harmful and your prescriber may advise you to avoid certain foods.

In the case of Lamotrigine:

  • there are no specific foods that you must exclude from your diet when taking Lamotrigine

Driving and operating machinery

When taking any medicine you should be aware that it might interfere with your ability to drive or operate machinery safely.

In the case of Lamotrigine:

  • this medicine could affect your ability to drive or operate machinery

You should seek advice from your prescriber as to whether you may drive while taking this medicine.

Family planning and pregnancy

Most medicines, in some way, can affect the development of a baby in the womb. The effect on the baby differs between medicines and also depends on the stage of pregnancy that you have reached when you take the medicine.

In the case of Lamotrigine:

  • if you are taking Lamotrigine and are planning to have a baby you must contact your prescriber
  • the use of this medicine during pregnancy is not recommended. You should only take this medicine during pregnancy if your doctor thinks that you need it
  • if you are taking Lamotrigine and could become pregnant, you must use effective contraception or abstain from penetrative sex. You must contact your prescriber if you become pregnant, or think you have become pregnant, while taking Lamotrigine
  • this medicine can make some oral contraceptive pills less effective. If this could affect you, it is important that you discuss contraception with your prescriber. If you are taking Lamotrigine and an oral contraceptive pill and you experience any change in your bleeding patterns you should contact your prescriber.

You need to discuss your specific circumstances with your doctor to weigh up the overall risks and benefits of taking this medicine. You and your doctor can make a decision about whether you are going to take this medicine during pregnancy.

If the decision is that you should not have Lamotrigine, then you should discuss whether there is an alternative medicine that you could take during pregnancy.


Certain medicines can pass into breast milk and may reach your baby through breast-feeding.

In the case of Lamotrigine:

  • this medicine passes into breast milk. Taking Lamotrigine and breast-feeding may affect your baby

Before you have your baby you should discuss breast-feeding with your doctor or midwife. They will help you decide what is best for you and your baby based on the benefits and risks associated with this medicine. You should only breast-feed your baby while taking this medicine on the advice of your doctor or midwife.

Taking other medicines

If you are taking more than one medicine they may interact with each other. At times your prescriber may decide to use medicines that interact, in other cases this may not be appropriate.

The decision to use medicines that interact depends on your specific circumstances. Your prescriber may decide to use medicines that interact, if it is believed that the benefits of taking the medicines together outweigh the risks. In such cases, it may be necessary to alter your dose or monitor you more closely.

Tell your prescriber the names of all the medicines that you are taking so that they can consider all possible interactions. This includes all the medicines which have been prescribed by your GP, hospital doctor, dentist, nurse, health visitor, midwife or pharmacist. You must also tell your prescriber about medicines which you have bought over the counter without prescriptions.

The following medicines may interact with Lamotrigine:

  • aripiprazole
  • atazanavir/ritonavir
  • bupropion
  • carbamazepine
  • ethinylestradiol/levonorgestrel
  • gabapentin
  • lopinavir/ritonavir
  • metformin
  • olanzapine
  • oxcarbazepine
  • phenobarbital
  • phenytoin
  • primidone
  • rifampicin
  • risperidone
  • topiramate
  • valproate
  • varenicline

The following types of medicine may interact with Lamotrigine:

  • hormone replacement therapy
  • oral contraceptives

If you are taking Lamotrigine and one of the above medicines or types of medicines, make sure your prescriber knows about it.

Complementary preparations and vitamins

Medicines can interact with complementary preparations and vitamins. In general, there is not much information available about interactions between medicines and complementary preparations or vitamins.

If you are planning to take or are already taking any complementary preparations and vitamins you should ask your prescriber whether there are any known interactions with Lamotrigine.

Your prescriber can advise whether it is appropriate for you to take combinations that are known to interact. They can also discuss with you the possible effect that the complementary preparations and vitamins may have on your condition.

If you experience any unusual effects while taking this medicine in combination with complementary preparations and vitamins, you should tell your prescriber.

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