Amitriptyline (Amitriptyline 25mg/5ml oral solution sugar free)



Information specific to: Amitriptyline 25mg/5ml oral solution sugar free when used in Depression.

Amitriptyline (Am-ee-trip-till-een hi-droh-clor-ride) is a medicine which is used in depression and nocturnal enuresis.

The information in this Medicine Guide for amitriptyline varies according to the condition being treated and the particular preparation used.

Your medicine

Amitriptyline hydrochloride is used to treat depression. It is thought that Amitriptyline hydrochloride increases the activity and levels of certain chemicals in the brain. This can improve symptoms of depression. Amitriptyline hydrochloride is also used to treat nocturnal enuresis.

Some people who take Amitriptyline hydrochloride and have depression may find that it intensifies depression and suicidal feelings in the early stages of treatment. These people have an increased risk of self-harm or suicide in the early stages of taking Amitriptyline hydrochloride. As Amitriptyline hydrochloride starts to work these risks decrease.

If you are taking Amitriptyline hydrochloride, or you care for someone who is taking Amitriptyline hydrochloride, you need to look out for changes in thoughts or behaviour that could be linked to self-harm or suicide.

If you notice any of these changes or are worried about how Amitriptyline hydrochloride is affecting you or someone you care for, you should contact your prescriber, a mental health professional or call 111 as soon as possible.

It is important that you discuss with your prescriber how long it will take before you can expect to feel any benefits from taking Amitriptyline hydrochloride.

Other information about Amitriptyline hydrochloride:

  • your doctor may start you on a low dose of this medicine and then increase the dose gradually depending on how you respond to treatment

Do not share your medicine with other people. It may not be suitable for them and may harm them.

The pharmacy label on your medicine tells you how much medicine you should take. It also tells you how often you should take your medicine. This is the dose that you and your prescriber have agreed you should take. You should not change the dose of your medicine unless you are told to do so by your prescriber.

If you feel that the medicine is making you unwell or you do not think it is working, then talk to your prescriber.

Whether this medicine is suitable for you

Amitriptyline hydrochloride is not suitable for everyone and some people should never use it. Other people should only use it with special care. It is important that the person prescribing this medicine knows your full medical history.

Your prescriber may only prescribe this medicine with special care or may not prescribe it at all if you:

  • are about to have surgery
  • are allergic or sensitive to or have had a reaction to any of the ingredients in the medicine
  • are breast-feeding
  • are elderly
  • are having electroconvulsive therapy
  • are recovering from a recent heart attack
  • are taking monoamine oxidase inhibitors or have taken them within the last 14 days
  • have cardiovascular problems
  • have had epilepsy
  • have had urinary retention
  • have heart block
  • have heart problems
  • have heart arrhythmias
  • have hyperthyroidism
  • have liver problems
  • have mania
  • have narrow angle glaucoma
  • have or have had thoughts of committing suicide
  • have porphyria
  • have prostate problems
  • have psychosis
  • have raised pressure in the eye
  • have schizophrenia

Furthermore the prescriber may only prescribe this medicine with special care or may not prescribe it at all for a child who is under the age of 16 years.

As part of the process of assessing suitability to take this medicine a prescriber may also arrange tests:

  • to check that this medicine is not having any undesired effects
  • to check that this medicine is having the desired effect

Over time it is possible that Amitriptyline hydrochloride can become unsuitable for some people, or they may become unsuitable for it. If at any time it appears that Amitriptyline hydrochloride has become unsuitable, it is important that the prescriber is contacted immediately.


Alcohol can interact with certain medicines.

In the case of Amitriptyline hydrochloride:

  • this medicine may increase the effects of alcohol

You should seek advice from your prescriber as to whether you may drink alcohol while taking this medicine.


Medicines can interact with certain foods. In some cases, this may be harmful and your prescriber may advise you to avoid certain foods.

In the case of Amitriptyline hydrochloride:

  • there are no specific foods that you must exclude from your diet when taking Amitriptyline hydrochloride

Driving and operating machinery

When taking any medicine you should be aware that it might interfere with your ability to drive or operate machinery safely.

In the case of Amitriptyline hydrochloride:

  • this medicine could affect your ability to drive or operate machinery

You should see how this medicine affects you before you judge whether you are safe to drive or operate machinery. If you are in any doubt about whether you should drive or operate machinery, talk to your prescriber.

Family planning and pregnancy

Most medicines, in some way, can affect the development of a baby in the womb. The effect on the baby differs between medicines and also depends on the stage of pregnancy that you have reached when you take the medicine.

In the case of Amitriptyline hydrochloride:

  • the use of this medicine during pregnancy is not recommended. You should only take this medicine during pregnancy if your doctor thinks that you need it
  • if you take this medicine during the late stages of pregnancy, your baby may have withdrawal symptoms from Amitriptyline hydrochloride after birth

You should discuss your personal circumstances with your doctor if you are pregnant or want to become pregnant. This is so that together you can make a decision about what treatment you may need during your pregnancy.

You should discuss whether there are any other medicines which you could take during pregnancy which would treat your condition.


Certain medicines can pass into breast milk and may reach your baby through breast-feeding.

In the case of Amitriptyline hydrochloride:

  • this medicine passes into breast milk

Women who are taking Amitriptyline hydrochloride must not breast-feed. If you wish to breast-feed you should discuss with your prescriber whether there are any other medicines you could have. You should not stop this medicine without taking advice from your doctor.

Taking other medicines

If you are taking more than one medicine they may interact with each other. At times your prescriber may decide to use medicines that interact, in other cases this may not be appropriate.

The decision to use medicines that interact depends on your specific circumstances. Your prescriber may decide to use medicines that interact, if it is believed that the benefits of taking the medicines together outweigh the risks. In such cases, it may be necessary to alter your dose or monitor you more closely.

Tell your prescriber the names of all the medicines that you are taking so that they can consider all possible interactions. This includes all the medicines which have been prescribed by your GP, hospital doctor, dentist, nurse, health visitor, midwife or pharmacist. You must also tell your prescriber about medicines which you have bought over the counter without prescriptions.

The following medicines may interact with Amitriptyline hydrochloride:

  • adrenaline
  • bethanidine
  • cimetidine
  • clonidine
  • debrisoquine
  • disulfiram
  • ephedrine
  • ethchlorvynol
  • guanethidine
  • isoprenaline
  • methylphenidate
  • noradrenaline
  • phenylephrine
  • phenylpropanolamine
  • ritonavir
  • thioridazine

The following types of medicine may interact with Amitriptyline hydrochloride:

  • anaesthetics
  • anticholinergic agents
  • antidepressants
  • antihypertensives
  • barbiturates
  • medicines that are used to treat thyroid problems
  • medicines which depress the CNS
  • monoamine oxidase inhibitors
  • protease inhibitors
  • sympathomimetics

If you are taking Amitriptyline hydrochloride and one of the above medicines or types of medicines, make sure your prescriber knows about it.

Complementary preparations and vitamins

Medicines can interact with complementary preparations and vitamins.

Make sure you tell your prescriber the names of all the complementary preparations and vitamins that you are taking or are planning to take.

Your prescriber can then decide whether it is appropriate for you to take combinations that are known to interact.

In the case of Amitriptyline hydrochloride:

  • this medicine interacts with St. John's Wort

If you have been prescribed Amitriptyline hydrochloride you should only take something on the above list on the specific advice of your prescriber or pharmacist.

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