Multiple myeloma - Causes 

Causes of multiple myeloma 

It is not known exactly what causes the plasma cells inside the bone marrow to become cancerous.

Studies have suggested that the factors listed below may increase your chance of developing multiple myeloma:

  • having a close relative with the condition
  • being obese (extremely overweight)
  • having a diet that's low in fish and/or green vegetables
  • havingĀ HIV or AIDS
  • using hair dyes, or having a job that involves exposure to hair dyes
  • working as a farmer
  • working with meat
  • working with sheet metals
  • working in the petroleum industry
  • working with radiation
  • having a job that exposes you to wood dust
  • having a condition where the immune system attacks healthy tissue, such asĀ rheumatoid arthritis

It's unclear exactly how these risk factors may increase the risk of developing myeloma.

  • show glossary terms

Antibodies
Antibodies and immunoglobins are proteins in the blood. They are produced by the immune system to fight against bacteria, viruses and disease.
Bone marrow
Bone marrow is the soft, spongy tissue in the centre of bones that produces blood cells.
Plasma
Plasma is the liquid part of blood, which holds other blood cells together.

Last reviewed: 06/07/2011

Next review due: 06/07/2013

What is cancer?

Cancer begins with a change in the deoxyribonucleic acid (DNA) that's found in all human cells. DNA provides the cells with a basic set of instructions, such as when to grow and reproduce.

A change to the DNA alters these instructions so that the cells carry on growing and start to multiply uncontrollably.

In the case of multiple myeloma, this leads to an excess of plasma cells inside the bone marrow.