'Leaky gut syndrome' 

  • Overview


'Leaky gut syndrome' is not a recognised medical diagnosis 

'Leaky gut syndrome' is a proposed condition some health practitioners claim is the cause of a wide range of long-term conditions, including chronic fatigue syndrome and multiple sclerosis (MS).

Proponents of 'leaky gut syndrome' claim that many symptoms and diseases are caused by the immune system reacting to germs, toxins or other large molecules that have been absorbed into the bloodstream via a porous ("leaky") bowel.

There is little evidence to support this theory, and no evidence that so-called "treatments" for "leaky gut syndrome", such as nutritional supplements and a gluten-free diet, have any beneficial effect for most of the conditions they are claimed to help.

While it is true that certain factors can make the bowel more permeable, this probably does not lead to anything more than temporary mild inflammation of an area of the bowel.

This page:

  • explains what we know about the bowel lining – including how this can become more permeable, the effect this has and the few cases where treatment is warranted 
  • explains why we should be sceptical about "leaky gut syndrome"
  • provides advice for anyone suffering unexplained symptoms and links to reliable information that might help you  

The bowel lining: what we know

The inside of the bowel is lined by a single layer of cells that make up the mucosal barrier (the barrier between the inside of the gut and the rest of the body).

This barrier is effective at absorbing nutrients, but prevents most large molecules and germs passing from inside the bowel into the bloodstream and potentially irritating the bowel lining.

Effect of alcohol and certain painkillers

Alcohol, aspirin and non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen are well-known irritants of the bowel lining. They damage the seals between cells, allowing water-soluble substances to pass through the gaps and into the bloodstream.

Gastroenterologists (specialists in diseases of the gut) generally agree that these irritants do not usually cause anything more than just mild inflammation of a particular area of the bowel, and the bowel lining becomes even more porous as a result. At the very worst, the inflammation might be bad enough to cause ulcers in the bowel lining.

The vast majority of people who consume lots of alcohol or regularly take aspirin or ibuprofen have none of the widespread symptoms or health conditions that proponents of "leaky gut syndrome" mention – health problems you would expect if the theory was true.

Effect of certain bowel diseases and treatments

The following diseases and treatments are also known to damage the seals in the bowel lining:

Generally, only in these situations might treatment for a "leaky" bowel be necessary. For example, people with Crohn's disease usually benefit from medication to reduce the bowel inflammation, and may also benefit from a liquid diet (read more about the treatment of Crohn's disease).

Why we should be sceptical about 'leaky gut syndrome'

Unproven theory

Exponents of "leaky gut syndrome" – largely nutritionists and practitioners of complementary and alternative medicine – believe the bowel lining can become irritated and 'leaky' as the result of a much wider range of factors, including an overgrowth of yeast or bacteria in the bowel, a poor diet and the overuse of antibiotics.

They believe that undigested food particles, bacterial toxins and germs can pass through the "leaky" gut wall and into the bloodstream, triggering the immune system and causing persistent inflammation throughout the body. This, they say, is linked to a much wider range of health problems and diseases, including:

The above theory is vague and still largely unproven.


Some scientists and sceptics believe that people who promote "leaky gut syndrome" are either misguided and read too much into the theory, or are deliberately misleading the public to make money from the "treatments" they sell.

The sorts of products sold online include diet books, nutritional supplements (containing probiotics, for example), gluten-free foods and other special diets, such as low sugar or antifungal diets. These have not been proven to be beneficial for many of the conditions they are claimed to help.

Some websites even promote various nutritional "treatments" for autism, despite conflicting evidence. A 2006 review explored the potential effect of manipulating the diet of people with autism, concluding that the dietary treatments were "cumbersome" and not proven to be effective. 

Generally, eliminating foods from the diet is not a good idea unless it's strictly necessary (for example, if you have coeliac disease), as it can lead to nutritional deficiencies. 

Advice and further information

If you have symptoms that are not explained by a diagnosis, it may help to read our page on medically unexplained symptoms. Such mystery symptoms are surprisingly common, accounting for a fifth of all GP consultations in the UK. 

If you have been diagnosed with a particular health condition, you can look it up in our A-Z index of treatments and conditions, where you will find reliable, evidence-based information about its treatment.

Generally, it is wise to view "holistic" and "natural health" websites with scepticism – do not assume that the information they provide is correct or based on scientific fact or evidence.

Read more about the role of evidence in medicine and what we mean when we say a treatment "works"

Page last reviewed: 09/04/2013

Next review due: 09/04/2015


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The 9 comments posted are personal views. Any information they give has not been checked and may not be accurate.

blueisbetter said on 08 November 2014

For 25 years now `i have been from dietician to gastroenterologist, without proper examination of the gut. My IBS symptoms have worsened over the years. My diet is appalling. No-one seems to help or take me seriously.
I cannot understand the NHS approach.
A senior dietician told me that no-one in the NHS has really researched IBS thoroughly over time to determine the causes. How do they know that intestinal candidiasis is not a factor then?
If someone can give relief and advice which works for you why diss it?
I was thinking of getting some tests done for the above condition and was in a dilemma until I read the reviews here from ordinary people with debilitating symptoms ignored by the NHS. I will definitely get tests done now.

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GinaB4 said on 02 November 2014

Take no notice of this article. The NHS are just pulling wool over our eyes because all they want is some hard evidence as proof simply because they do not believe this exists. If you can afford to, go for private treatment. GPs are unlikely to help you in this case.

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JavierStroud said on 29 October 2014

Decide for yourself whether this is a real condition or not….

Leaky gut and autoimmune diseases.Fasano A.
Clin Rev Allergy Immunol. 2012 Feb;42(1):71-8.

The article is convincing.

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ChrisDS said on 24 October 2014

Completely cutting out all beans and pears is tha only treatment you need really. Bean sprouts are a nono, soya beans are only bean in name!

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KTCdf said on 19 May 2014

LGS has different symptoms in different people (can be gut, skin, weight or mental health related). Below are the symptoms that I had & the treatments that worked for me. This may or may not work for you but could be worth a try!

* chronic diarreah
* stomach cramps, indigestion, nausea everyday, aggravated by eating
* exhaustion
* joint pain and muscle aches
* extensive food intolerances
* inability to concentrate/focus

* Anti-candida diet (as awful as this is, it does work)- essentially, you have to exclude ALL refined sugars, wheat, dairy and yeast (inc most alcohol) for 6 weeks - 3 months.
* Kineseology treatment - this is to test the levels of inflammation in the body and how severe the reactions are to various foods. Kineseologists also prescribe supplements to heal the gut & strengthen the immune system.
* Acupuncture (reflexology or reiki are other options) to re balance & strengthen immune system & organs affected by the damage caused by candida over the years.
* Chiropractic (for joints)
* Yoga (pilates or tai chi also good) to gently improve physical strength & stamina.
* A lot of rest. Fresh air. Plain diet & a lot of water.

This is not a quick fix and requires a lot of effort. I know it works because if I slack for a while, my symptoms return.

I hope this helps someone. The more information that is out there about potential treatments, the less people will have their lives ruined by this debilitating condition.

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KTCdf said on 19 May 2014

It is really disappointing that the medical profession continue to disregard this condition due to lack of "proof". 1000s of people are incredibly sick with this debilitating illness & complementary therapies are currently the only treatments that actually work.

I have been chronically ill for over 14 years with IBS, multiple food intolerances and chronic fatigue. I had to leave a successful career, stop exercising & virtually stop socialising due to having to spend most of my time either in bed or in the bathroom. I have been told by numerous Doctors that there is nothing that they can do due to "lack of proof or understanding" of these symptoms.

I, like many others was forced to turn to complementary therapists because there literally was nowhere else to go. I have been treated for the last 2 years & am now well on my way back to good health. I was able to start a part time job & have increased it to full time. I am now able to do gentle exercise & can eat more food. I am lucky that I can afford to pay for such advice & treatment. Many people can't which is why it is so important that the powers that be at the NHS open their eyes.

Treating LGS or whatever name you wish to give it, does not cost a lot of money & does not require medication. Yet getting many people back to full health - those who are suffering from chronic bowel disease, depression, IBS, asthma, food intolerances etc (not to mention the secondary complications) & who are costing the NHS & the economy millions - WOULD SAVE A FORTUNE.

Please please secure some funding to coordinate the findings of the numerous independent complementary therapists up & down the country who are treating people with this debilitating condition and getting them back to full health every day. The evidence is there, you just need to look.

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Loulabelle2014 said on 11 May 2014

This article is ridiculous. For at least 3 years I kept going to my Gp saying I do not feel well. My skin was flaring up all the time and I was riddled with constant yeast infections. Untreated, over time I started having reactions to just about everything under the sun, chemicals, foods, and cosmetics I've used for years. I was sent away with steroid cream and a flea in my ear. My oh my how wrong they get things. A private allergy test showed I have various food intolerances etc. And the Candida has gone systemic. Who writes these things!!!!

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chlorophyle said on 11 April 2014

I have a diagnosis of bipolar disorder and have had muscle pain, frozen shoulder, vertigo, costochondritis (had a trip to A &E that ruled out heart problems but the machines confirmed that my blood pressure was erratic) , and chronic back pain for 25 years. In the past 2 years I have realised that my physical and mental problems are all directly affected by the health of my gut. My body gave me no obvious clues that wheat was a major trigger until I had excluded it for 6 weeks and now my system flushes it out very quickly if I have accidentally eaten gluten or any similar protein ( the type of proteins called lectins found in large quantities in wheat, legumes, potatoes and dairy are particularly hard to digest). I do better eating a basically a paleo (stone age) diet excluding grains, potatoes and legumes but instead lots of green vegetables with meat or fish. You cannot feel a leaky gut - only its after-effects. I have no current health issues. My psychiatrist describes me as "in remission" in letters to my GP.
Dr. Marios Hadjivassiliou is a Professor of Neurology at Sheffield Teaching Hospitals NHS Foundation Trust and his work in connecting neurological disorders with gut disorders is a matter of scientific fact. The medical “experts” in the UK and USA have a lot to learn.

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Loobizaz said on 28 January 2014

I had salmonella and campylobacter in 2006. Since this time I have developed food allergies to wheat, tomatoes and oranges - these cause various symptoms from migraine/sinus reaction, joint pain to diahorrea. I have also become intolerant to almost all antibiotics.
I strongly believe that I have increased permeability in my gut wall, hence these problems that I now experience with my health.
I never used to pick up stomach bugs but now get everything going round! Alternative practitioners have not approached me or tried to peddle their solutions - but medicine is failing me, so I will approach them.
I don't find this article very helpful as it is almost suggesting that I am a hyperchondriac.

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