Cluster headaches - Treatment 

Treating cluster headaches 

Cluster headaches can't be treated with over-the-counter painkillers, such as paracetamol, as they're too slow to take effect. You'll need to be treated at a specialist clinic.

There are two main types of treatment:

  • those that relieve cluster headaches
  • those that prevent cluster headaches

Relieving cluster headaches


A drug called sumatriptan (Imigran) is commonly used to treat cluster headaches. It works in a similar way to a brain chemical called 5HT. It causes your blood vessels to narrow, reducing bloodflow to the brain.

Sumatriptan is usually given as an injection, which you can give yourself as soon as the headache starts. It works very quickly (within about 10 minutes).

The adult dose in an injection is 6mg and you can take a maximum of two injections in 24 hours, as long as they're at least an hour apart.

If an injection is unsuitable, sumatriptan or zolmitriptan nasal spray may be used.

Some people have mild side effects, such as nausea, dizziness, tiredness and a dry mouth. If you have any side effects, talk to your GP. You shouldn't take it if you have heart disease or peripheral vascular disease.

Oxygen therapy

Your doctor may prescribe oxygen cylinders to use at home. You breathe a high flow of pure oxygen through a mask for about 15 minutes, up to five times a day. It's a safe treatment and there's evidence it is effective in relieving cluster headaches.

Read more information about home oxygen treatments.

Preventing cluster headaches

If attacks of cluster headaches happen often or last more than three weeks, preventative treatments are usually necessary. This involves starting treatment as soon as the headaches begin, and continuing every day throughout the period of headaches until they end.

The National Institute for Health and Care Excellence (NICE) recommends that verapamil may be considered as a preventative treatment for cluster headaches.

Verapamil tablets are usually used to treat heart problems but are also effective at preventing cluster headaches. The heart must be closely monitored with ECGs (electrocardiograms) when the dose of verapamil is increased.

Alternative treatments may be considered if verapamil is not effective. Preventative treatments must only be administered under the guidance and close monitoring of a specialist. Some of these treatments are outlined below.


Lithium tablets are normally used to treat mood disorders, but can help cluster headaches. The level of lithium in your blood may need to be carefully monitored to avoid side effects.

Occipital nerve anaesthetic block

The occipital nerve runs from the top of the spine to the scalp and is involved in the pain of cluster headaches. Occipital nerve block is the injection of a local anaesthetic, such as lidocaine, into the back of the head to relieve the pain of cluster headaches for a period of time (usually several weeks). Although there's a lack of research evidence on this treatment, it appears to provide relief for some patients.

Page last reviewed: 11/04/2013

Next review due: 11/04/2015


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The 3 comments posted are personal views. Any information they give has not been checked and may not be accurate.

harrietjt said on 07 September 2014

Response re joliemsa: my husband has had these every day for 6 years, up to 10 attacks. Imperative to be referred to a specialist, ensure they are not just a headache specialist, but also expert in CH. The consultant will write to the doctor directing the medication. Then you will be able to insist it is not witheld. We have had this battle repeatedly, I call the GP practice manager, refer them to the consultants letter, and it gets sorted out. I think the issue is that this medication when used for migraines can cause Medication Overuse Headache (MOH) and because most GPs we have met have not heard of CH they think it is a name we have made up for migraine and then refuse the meds. MOH does not apply to CH and the meds should not be withheld. OUCH UK have helped us make our way through all this and will guide you to get what you need to have.

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tow52 said on 30 May 2014

Ihave had cluster headaches for about 7years but only found out 4 years ago

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Joliemsa said on 23 April 2014

My son in law has been suffering with these for over 20 years now, we have only just got a diagnosis. He has oxygen and I have been fighting to get the injections ( seems the cost is a large issue) he has managed to get prescription for two injections, but when he tried to get another script, the doctor refused, stating he is most likely addicted! This is so infuriating, the medical profession really needs to wake up to this terrible affliction, it is the most painful thing known to mankind, this poor man is to be married next week and his cluster (beast) will ruin it. He also has a baby due, can you imagine how awful that will be with the beast around? The doctor must not put cost before lives. Please educate yourselves on this terrible condition

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