Arterial thrombosis is a blood clot that develops in an artery. It is very dangerous as it can obstruct the flow of blood to major organs.

Depending on where the clot forms, arterial thrombosis can cause several serious conditions, including:

  • heart attack – when the blood flow to the heart is affected
  • stroke – when the blood flow to the brain is affected
  • peripheral arterial disease (PAD), also known as peripheral vascular disease (PVD) – when the blood flow in the legs is affected

Heart attack and stroke are leading causes of death in the UK.

Who's at risk?

Most cases of arterial thrombosis are caused when an artery is damaged by atherosclerosis. This is where fatty deposits called plaque build up on the walls of the arteries, causing them to harden and narrow. If the plaque ruptures (bursts), a blood clot may develop.

You're at an increased risk of developing an arterial blood clot if you:

The risk of arterial thrombosis also increases with age, so older people are more commonly affected.

Treating arterial thrombosis

It is sometimes possible to treat arterial thrombosis with medication or surgery.


In some cases, a type of medication called a thrombolytic can be used to dissolve blood clots and restore the flow of blood in an artery. Examples of thrombolytic medicines include alteplase and reteplase.

These medicines are most effective if they are used as soon as possible after a heart attack or stroke starts.


Surgery for arterial thrombosis involves unblocking the affected artery or re-routing blood flow around the blockage. The type of surgery used will depend on the location and severity of your condition.

For example, you may need heart surgery if the blood clot is in an artery that supplies blood to your heart. Operations used to treat this include:

  • coronary stent placement – where a balloon is inflated in a blocked artery (angioplasty) to allow a hollow metal tube called a stent to be placed so it can widen the artery and stop it from becoming blocked again
  • coronary artery bypass graft – where a blood vessel taken from another part of the body is used to bypass the point of the blockage

If you have a blood clot in your neck, you may have surgery called carotid endarterectomy. During this operation, the surgeon makes a cut in your neck to open up the artery and remove the fatty deposits.

Reducing your risk

It is not possible to prevent blood clots altogether, but there are a number of ways you can minimise your risk.


If you have previously had a blood clot, you may need to take medicines to reduce the risk of it happening again. These include:

  • statins to lower your blood cholesterol levels 
  • anticoagulant medicines (such as warfarin) or antiplatelet medicines (such as low-dose aspirin or clopidogrel) to thin the blood and reduce the risk of clotting
  • antihypertensive medicines to reduce high blood pressure, such as angiotensin-converting enzyme (ACE) inhibitors


You can also reduce your risk of developing arterial thrombosis and heart disease by:

Heart attack: real story

Mike Smith has had three heart attacks. As he nears 60 and enjoys life to the full, he explains how the attacks affected him and how his recovery was different for each of them.

Media last reviewed: 19/03/2013

Next review due: 19/03/2015

Other types of blood clot

As well as arterial thrombosis, there are several other types of blood clot, including:

  • venous thromboembolism (VTE) – a blood clot that develops in a vein
  • deep vein thrombosis (DVT) – a blood clot in one of the deep veins in the body, usually the leg
  • embolism – a condition where the blood flow in an artery is blocked by a foreign body, such as a blood clot or an air bubble
  • pulmonary embolism – a blood clot in the pulmonary artery, which is the blood vessel that transports blood from the heart to the lungs

Page last reviewed: 05/03/2013

Next review due: 05/03/2015