Painkillers, ibuprofen - Side effects 

Side effects of ibuprofen 

Reporting side effects

The Yellow Card Scheme allows you to report suspected side effects from any type of medicine you are taking. It is run by a medicines safety watchdog called the Medicines and Healthcare Products Regulatory Agency (MHRA). See the Yellow Card Scheme website for more information.

Ibuprofen can cause a number of side effects. For this reason, the lowest possible dose of ibuprofen should be taken for the shortest possible time to control your symptoms.

Common side effects of ibuprofen include:

  • nausea (feeling sick)
  • vomiting (being sick)
  • diarrhoea (passing loose, watery stools)
  • indigestion (dyspepsia)
  • abdominal (tummy) pain

Less common side effects include:

  • headache
  • dizziness
  • fluid retention (bloating)
  • raised blood pressure
  • gastritis (inflammation of the stomach)
  • duodenal or gastric ulcers (open sores in the digestive system, see Peptic ulcer)
  • allergic reactions, such as a rash
  • worsening of asthma symptoms by causing bronchospasm (narrowing of airways)

Less common side effects can also include malaena (black stools) and haematemesis (blood in your vomit). These side effects can indicate that there is bleeding in your stomach.

Taking ibuprofen, particularly at high doses over long periods of time, can increase your risk of:

  • stroke, when the blood supply to the brain is disturbed
  • heart attacks, when the blood supply to the heart is blocked

In females, long-term use of ibuprofen can sometimes be associated with reduced fertility. This is usually reversible when you stop taking ibuprofen.

See the patient information leaflet that comes with your medicine or the Medicines information section for a full list of side effects.

Ability to drive

Ibuprofen is unlikely to affect your ability to drive safely, although some people may feel dizzy after taking ibuprofen. If you experience dizziness, do not drive.

  • show glossary terms

Inflammation
Inflammation is the body's response to infection, irritation or injury, which causes redness, swelling, pain and sometimes a feeling of heat in the affected area.

Stomach
The sac-like organ of the digestive system that helps digest food by churning it and mixing it with acids to break it down into smaller pieces.

Last reviewed: 04/08/2010

Next review due: 04/08/2012

Comments are personal views. Any information they give has not been checked and may not be accurate.

Lamulady said on 31 March 2012

The article on any side effects of using ibuprofen for a long period of time was, to me, completely useless. I have L.S.S.. I have to take pain relievers if I wish to move anywhere, walk etc. I have been prescribed Gabapentin which has limited success but the contra effects are extreme lassitude & I fear, possible weight gain which is dire. At the moment I am 72kg which is about 3kg below my normal weight whilst in G.B. but, having been in India for 4 months I should have dropped to well under 70kg because of excess heat/sweating , reduced appetite & eating less carbohydrates than I do whilst at home.I am taking about 1g of paracetamol some days & alternate with small amount of iboprufen as well as the gabapentin. However, even taking them all in one dose does not always facilitate my walking as my legs, apart from the normal feet/calf pain sometimes burn right up to the backs of the thighs. Sometimes it becomes impossible to walk more than a few feet at a time because the leg muscles seem unable to function correctly & I become like a drunk...legless! I am turning to all kinds of help lines as I have become worse so fast. The problem began about 2 years ago & after a final MRI scan last October was diagnosed with Stenosis of the lower vertebrae (2 of which are fused anyway from birth.)
I am not sure if this letter will provide any more results than my Doctor is already trying for.

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The Yellow Card Scheme

The MHRA has produced a video that explains how the Yellow Card Scheme can be used to report the side effects of medication