Zantac (Zantac 150mg tablets)

Zantac (Zantac 150mg tablets)

Information specific to: Zantac 150mg tablets when used in Indigestion and excess acid.

Zantac (Zan-tak) is a medicine which is used in a number of conditions - an example is treatment of benign gastric ulceration. Zantac contains ranitidine hydrochloride. It is supplied by GlaxoSmithKline UK.

The information in this Medicine Guide for Zantac varies according to the condition being treated and the particular preparation used.

Your medicine

Zantac belongs to a class of medicines called H2-receptor antagonists. This medicine works by reducing the amount of acid in your stomach. It is used to treat gastrointestinal ulcers as well as to relieve heartburn and indigestion.

In some cases, however, heartburn, indigestion and other similar symptoms may not be due to ulcers, but to other, more serious conditions. This means that treatment with Zantac could have the unwanted effect of causing a delay in your doctor diagnosing a more serious condition.

Zantac is sometimes used in addition to one or two antibiotics to treat gastrointestinal ulcers caused by H pylori bacteria. This is known as dual therapy when one antibiotic is used and triple therapy when two antibiotics are used.

This combination of medicines kills the bacteria and prevents ulcers from recurring.

Do not share your medicine with other people. It may not be suitable for them and may harm them.

The pharmacy label on your medicine tells you how much medicine you should take. It also tells you how often you should take your medicine. This is the dose that you and your prescriber have agreed you should take. You should not change the dose of your medicine unless you are told to do so by your prescriber.

If you feel that the medicine is making you unwell or you do not think it is working, then talk to your prescriber.

Whether this medicine is suitable for you

Zantac is not suitable for everyone and some people should never use it. Other people should only use it with special care. It is important that the person prescribing this medicine knows your full medical history.

Your prescriber may only prescribe this medicine with special care or may not prescribe it at all if you:

  • are allergic or sensitive to or have had a reaction to any of the ingredients in the medicine
  • are elderly
  • are immunosuppressed
  • are middle aged or over and have new or different symptoms of indigestion
  • are taking a non-steroidal anti-inflammatory medicine
  • have diabetes
  • have had peptic ulcers
  • have kidney problems
  • have lung problems
  • have or have had porphyria

Furthermore the prescriber may only prescribe this medicine with special care or may not prescribe it at all for a child who is under the age of three years or who weighs less than 30 Kg.

As part of the process of assessing suitability to take this medicine a prescriber may also arrange tests:

  • to determine whether or not the medicine is suitable and whether it must be prescribed with extra care

Over time it is possible that Zantac can become unsuitable for some people, or they may become unsuitable for it. If at any time it appears that Zantac has become unsuitable, it is important that the prescriber is contacted immediately.


Alcohol can interact with certain medicines.

In the case of Zantac:

  • there are no known interactions between alcohol and Zantac


Medicines can interact with certain foods. In some cases, this may be harmful and your prescriber may advise you to avoid certain foods.

In the case of Zantac:

  • there are no specific foods that you must exclude from your diet when taking Zantac

Driving and operating machinery

When taking any medicine you should be aware that it might interfere with your ability to drive or operate machinery safely.

Like all medicines Zantac can cause side effects. You should see how this medicine affects you and then judge if you are safe to drive or operate machinery. If you are in any doubt, talk to your prescriber.

Family planning and pregnancy

Most medicines, in some way, can affect the development of a baby in the womb. The effect on the baby differs between medicines and also depends on the stage of pregnancy that you have reached when you take the medicine.

In the case of Zantac:

  • you should only take this medicine during pregnancy if your doctor thinks that you need it

You need to discuss your specific circumstances with your doctor to weigh up the overall risks and benefits of taking this medicine. You and your doctor can make a decision about whether you are going to take this medicine during pregnancy.

If the decision is that you should not have Zantac, then you should discuss whether there is an alternative medicine that you could take during pregnancy.


Certain medicines can pass into breast milk and may reach your baby through breast-feeding.

In the case of Zantac:

  • you should only take this medicine while breast-feeding if your doctor thinks you need it

Before you have your baby you should discuss breast-feeding with your doctor or midwife. They will help you decide what is best for you and your baby based on the benefits and risks associated with this medicine. You should only breast-feed your baby while taking this medicine on the advice of your doctor or midwife.

Taking other medicines

If you are taking more than one medicine they may interact with each other. At times your prescriber may decide to use medicines that interact, in other cases this may not be appropriate.

The decision to use medicines that interact depends on your specific circumstances. Your prescriber may decide to use medicines that interact, if it is believed that the benefits of taking the medicines together outweigh the risks. In such cases, it may be necessary to alter your dose or monitor you more closely.

Tell your prescriber the names of all the medicines that you are taking so that they can consider all possible interactions. This includes all the medicines which have been prescribed by your GP, hospital doctor, dentist, nurse, health visitor, midwife or pharmacist. You must also tell your prescriber about medicines which you have bought over the counter without prescriptions.

The following medicines may interact with Zantac:

  • atazanavir
  • delavirdine
  • gefitinib
  • glipizide
  • ketoconazole
  • midazolam
  • N-acetylprocainamide
  • procainamide
  • triazolam
  • warfarin

The following types of medicine may interact with Zantac:

  • coumarin anticoagulants

If you are taking Zantac and one of the above medicines or types of medicines, make sure your prescriber knows about it.

Complementary preparations and vitamins

Medicines can interact with complementary preparations and vitamins. In general, there is not much information available about interactions between medicines and complementary preparations or vitamins.

If you are planning to take or are already taking any complementary preparations and vitamins you should ask your prescriber whether there are any known interactions with Zantac.

Your prescriber can advise whether it is appropriate for you to take combinations that are known to interact. They can also discuss with you the possible effect that the complementary preparations and vitamins may have on your condition.

If you experience any unusual effects while taking this medicine in combination with complementary preparations and vitamins, you should tell your prescriber.

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