Risks of IVF 

Before starting IVF, it's important to be aware of the potential problems that could occur.

Some of the main risks are outlined below.

Medication side effects

Many women will have some reaction to the medications used during IVF. Most of the time, the side effects are mild and may include:

  • hot flushes
  • feeling down or irritable
  • headaches
  • restlessness
  • ovarian hyperstimulation syndrome (see below)

Contact the fertility clinic if you experience persistent or worrying side effects during treatment.

Multiple births

If more than one embryo is replaced in the womb as part of IVF treatment, there's an increased chance of producing twins or triplets.

Having more than one baby may not seem like a bad thing, but it significantly increases the risk of complications for you and your babies. Problems more commonly associated with multiple births include:

Your babies are also more likely to be born prematurely and/or with a low birthweight, and are at an increased risk of developing life-threatening complications such as neonatal respiratory distress syndrome (NRDS) or long-term disabilities, such as cerebral palsy.

NICE guidelines recommend that double embryo transfers should only be considered during treatment in women aged 40-42. Younger women should only be considered for a double embryo transfer if there are no top-quality embryos to choose from.

You can read more about the risks of multiple births on the One at a time website.

Ovarian hyperstimulation syndrome

Ovarian hyperstimulation syndrome (OHSS) is a rare complication of IVF. It occurs in women who are very sensitive to the fertility medication taken to increase egg production. Too many eggs develop in the ovaries, which become very large and painful.

OHSS generally develops in the week after egg collection. The symptoms can include:

  • pain and bloating low down in your tummy
  • feeling and being sick
  • shortness of breath
  • feeling faint

Severe cases can be dangerous. Contact your clinic as soon as possible if you have any of these symptoms. It may be necessary to cancel your current treatment cycle and restart with a lower dose of fertility medication.

Ectopic pregnancy

If you have IVF, you have a slightly higher risk of an ectopic pregnancy, where the embryo implants in the fallopian tubes rather than in the womb. This can cause pain in the tummy, followed by vaginal bleeding or dark vaginal discharge.

If you have a positive pregnancy test after IVF, you'll have a scan at six weeks to make sure the embryo is growing properly and that your pregnancy is normal.

Tell your doctor if you experience vaginal bleeding or stomach pain after having IVF and a positive pregnancy test.



Risks for older women

IVF treatment becomes less successful with age. In addition, the risk of miscarriage and birth defects increases with the age of the woman having IVF treatment.

Your doctor will discuss the increased risks that come with age, and can answer any questions you may have.

Page last reviewed: 01/06/2015

Next review due: 01/06/2017