Hormone replacement therapy (HRT) - How it is taken 

How HRT is taken 

There are several  ways hormone replacement therapy (HRT) can be taken.

HRT can be taken as:

  • a cream or gel: applied to the skin or directly into the vagina if you are experiencing vaginal dryness
  • tablets: taken by mouth or placed directly into your vagina to treat dryness
  • a patch you stick on your skin
  • an implant: small pellets of oestrogen are placed under the skin of your tummy, buttock or thigh

If you are only experiencing vaginal dryness, you may be advised to use a form of HRT that can be applied directly to your vagina.

Tablets, patches and implants are only usually required if you have other menopausal symptoms, such as hot flushes.

There are different combinations of HRT which may make it difficult for you to decide which one is best for you. Your GP will be able to advise you.

The hormones used in HRT will usually be prescribed at the lowest possible dose to control your symptoms. It may take a while to establish an effective dose for your symptoms. Tell your GP if you feel your current dose is not working.

When to stop taking HRT

Most women are able to stop taking HRT after their menopausal symptoms finish. This is usually two-to-five years after they start.

Gradually decreasing your HRT dose is usually recommended, rather than stopping suddenly. You may have a relapse of menopausal symptoms after you stop HRT but these should pass within a few months.

If you have symptoms that persist for several months after you stop HRT, or if you have particularly severe symptoms, contact your GP because treatment may need to be restarted, usually at a lower dose.

After you have stopped HRT, you may need additional treatment for vaginal dryness and to prevent osteoporosis (brittle bones). Creams and lubricants are available for vaginal dryness, and medicines called bisphosphonates have proved effective in treating osteoporosis.


Last reviewed: 11/05/2012

Next review due: 11/05/2014

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Comments are personal views. Any information they give has not been checked and may not be accurate.

Sidmouth49 said on 14 January 2013

I'm 63 and had been taking HRT since I was 41 - originally because of violent monthly migraines. My doctor had been encouraging me to think about coming off HRT when a couple of months ago I started having bleeding. A visit to the GP confirmed there was nothing serious going on, so I decided to go cold turkey rather than wean myself off them gradually - my reasoning being that if I was going to have bleeding, then it wasn't much point carrying on the HRT. Now, six weeks later, I think I am getting hot flushes, but then I tend to get very hot in bed anyway. One thing I was wary of was loss of libido and vaginal dryness, but this doesn't seem to have happened. One very odd positive side-effect is that very often I nw seem to be able to go through the night without getting up to go to the loo, which was unheard of for me! Has anyone else experienced this?
There was very little information available about what to expect when stopping HRT, apart from the usual problems of hot flushes, but one friend of mine said she didn't mind them cos it reduced her heating bills. For a little light relief, try listening to 'In Praise of the Menopause' by Lynn Heraud and Pat Turner!

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Love2BHealthy said on 29 June 2012

I took the HRT for about five tears , it was the best thing ever for me, it changed my life, I was suffering and felt extremely miserable. The symptons had been so intermitently that it took a long time to diagnos. When I came off it I tested myself by slowly coming off and waiting to see if the sweats, fatigue,sleeplessness and the emotional problem,like suddenly feeling weepy or irritable.
Once I felt confident that I was feeling well again I stopped getting my prescription, and never looked back.

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Zazou1 said on 29 February 2012

I was diagnosed with breast cancer in December 2011. I had to stop taking HRT immediately. Under HRT, I had a new lease of life: no hot flushes, much better libido, energy. All the advantages have gone. The hot flushes have come back with a vengeance and the lack of sleep has affected the quality of my life. However, these are my personal circumstances. I did not have the choice. If you are worried about taking HRT, talk to your GP (not always specialized enough to give YOU the correct balance of hormones and advice) and try to come off it slowing as hermit66 is suggesting. I also have a colleague who has been on HTR for 12 years and is fine. The difficulty is to find the right balance between the quality of life we want and the level of anxiety we can live with.

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hermit666 said on 19 August 2010

Not sure how you'll know when the symptoms should be finished- I was guided by my doctor. Tried 'alternative' HRT without success before using Prempak- stopped 99% of my symptoms and worked very well for me. Am now in my second month of coming off slowly . Taking reduced dose - depending on the type of HRT, can take it even slower by 1 day on original tablet, 1 on lower dose. So far no sudden onset of symptoms and not really expecting any. If they do suddenly appear, no reason why I can't go back on HRT for a while longer then retry in say 6 months. I'm not overweight and generally fit and healthy- for me, the benefits far outweighed any potential negatives.

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Moise said on 15 August 2010

"Most women should be able to stop taking HRT once their menopausal symptoms have finished. This is normally between two to five years." This is the crucial point and the one that puts me off taking HRT. How do you know when your menopausal symptoms have finished as hopefully you don't have any if you are on HRT? Also, will symptoms be severe when you come off it as presumably the drop of oestrogen is rapid? Has anyone done this so they can report back please?

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