Treating diabetes insipidus 

Treatments for diabetes insipidus aim to reduce the amount of urine your body produces.

Depending on the type of diabetes insipidus you have, there are several ways of treating your condition and controlling your symptoms.

Cranial diabetes insipidus

Mild cranial diabetes insipidus may not require any medical treatment.

Cranial diabetes insipidus is considered mild if you produce approximately 3-4 litres of urine over 24 hours.

If this is the case, you may be able to ease your symptoms by increasing the amount of water you drink, to avoid dehydration. Your GP or endocrinologist (specialist in hormone conditions) may advise you to drink a certain amount of water every day, usually at least 2.5 litres.

However, if you have more severe cranial diabetes insipidus, drinking water may not be enough to control your symptoms. As your condition is due to a shortage of antidiuretic hormone (ADH), your GP or endocrinologist may prescribe a treatment that takes the place of ADH, known as desmopressin (see below).


Desmopressin is a manufactured version of ADH that's more powerful than the ADH naturally produced by your body. It works just like natural ADH, stopping your kidneys producing urine when the level of water in your body is low.

Desmopressin can be taken as a nasal spray or in tablet form. If you're prescribed desmopressin as a nasal spray, you'll need to spray it inside your nose once or twice a day, where it's quickly absorbed into your bloodstream.

If you're prescribed desmopressin tablets, you may need to take them more than twice a day. This is because desmopressin is absorbed into your blood less effectively through your stomach than through your nasal passages, so you need to take more to have the same effect.

Your GP or endocrinologist may suggest switching your treatment to tablets if you develop a cold that prevents you from using the nasal spray.

Desmopressin is very safe to use and has few side effects. However, possible side effects can include:

If you take too much desmopressin or drink too much fluid while taking it, it can cause your body to retain too much water. This can result in:

  • headaches
  • dizziness
  • feeling bloated
  • hyponatraemia – a dangerously low level of sodium (salt) in your blood

Symptoms of hyponatraemia include:

  • a severe or prolonged headache
  • confusion
  • nausea and vomiting

If you think you may have hyponatraemia, stop taking desmopressin immediately and call your GP for advice. If this isn't possible, go to your local accident and emergency (A&E) department.

Thiazide diuretics

Thiazide diuretics are a type of medication that makes the urine more concentrated, so that it contains a high level of waste products.

By increasing the concentration of the urine, the medication reduces the amount of urine passed from the body.

Side effects are uncommon but include:

This last side effect is usually temporary and should resolve itself if you stop taking the medication.

Non-steroidal anti-inflammatory drugs (NSAIDs)

For reasons that are unclear, non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, help reduce urine volume further when they're used in combination with thiazide diuretics.

However, long-term use of NSAIDs increases your risk of developing a stomach ulcer. To counter this increased risk, an additional medication called a proton pump inhibitor (PPI) may be prescribed. PPIs help protect your stomach lining against the harmful effects of NSAIDs, reducing the risk of  ulcers forming.

Read more about the treating stomach ulcers.

Nephrogenic diabetes insipidus

If you have nephrogenic diabetes insipidus that's caused by taking a particular medication, such as lithium or tetracycline, your GP or endocrinologist may stop your treatment and suggest an alternative medication. However, don't stop taking it unless you've been advised to by a healthcare professional.

As nephrogenic diabetes insipidus is caused by your kidneys not responding to ADH, rather than a shortage of ADH, it can't be treated with desmopressin. However, it's still important to drink plenty of water to avoid dehydration.

If your condition is mild, your GP or endocrinologist may suggest reducing the amount of salt and protein in your diet, which will help your kidneys produce less urine. This may mean eating less salt and protein-rich food, such as processed foods, meat, eggs and nuts. Don't alter your diet without first seeking medical advice. Your GP or endocrinologist will be able to advise you about which foods to cut down on.

Read more about eating a healthy, balanced diet.

If you have more severe nephrogenic diabetes insipidus, you may be prescribed a combination of thiazide diuretics and an NSAID to help reduce the amount of urine your kidneys produce. 

Help with health costs

If you have diabetes insipidus, you're entitled to medical exemption (MedEx) certificates. This means you don't have to pay prescription charges for medication that you need to treat your condition.

See Help with health costs for more information about how to apply for a MedEx certificate.

Page last reviewed: 14/04/2014

Next review due: 14/04/2016