Depression - Causes 

Causes  

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Depression can be triggered by more than one factor 

There is no single cause of depression, you can develop it for different reasons.

Depression has many different triggers. For some, an upsetting or stressful life event, such as bereavement, divorce, illness, redundancy and job or money worries, can be the cause.

Often, different causes combine to trigger depression. For example, you may feel low after an illness and then experience a traumatic event, such as bereavement, which brings on depression.

People often talk about a 'downward spiral' of events that leads to depression. For example, if your relationship with your partner breaks down, you're likely to feel low, so you stop seeing friends and family, and you may start drinking more. All of this can make you feel even worse and trigger depression.

Some studies have also suggested you're more likely to get depression as you get older and that it's more common if you live in difficult social and economic circumstances.

Stressful events

Most people take time to come to terms with stressful events, such as bereavement or a relationship breakdown. When these stressful events happen, you have a higher risk of becoming depressed if you stop seeing your friends and family and you try to deal with your problems on your own.

Illness

You may have a higher risk of depression if you have a long standing or life-threatening illness, such as coronary heart disease or cancer.

Head injuries are also an often under-recognised cause of depression. A severe head injury can trigger mood swings and emotional problems.

Even a minor head injury can damage the pituitary gland, which is a pea-sized gland at the base of your brain that produces thyroid-stimulating hormones. This can cause a number of symptoms, such as extreme tiredness and a loss of interest in sex, which can in turn lead to depression. 

Personality

You may be more vulnerable to depression if you have certain personality traits, such as low self-esteem or being overly self-critical. This may be due to the genes you've inherited from your parents, or because of your personality or early life experiences. 

Family history

If someone else in your family, such as a parent or sister or brother, has suffered from depression in the past, then it's more likely that you will too.

Giving birth

Some women are particularly vulnerable to depression after pregnancy. The hormonal and physical changes, as well as the added responsibility of a new life, can lead to postnatal depression.

Loneliness

Becoming cut off from your family and friends can increase your risk of depression.

Alcohol and drugs

Some people try to cope when life is getting them down by drinking too much alcohol or taking drugs. This can result in a spiral of depression. 

Cannabis helps you relax, but there is evidence that, especially in teenagers, it can bring on depression.

And don't be tempted to drown your sorrows with a drink. Alcohol actually makes depression worse. 


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Last reviewed: 09/09/2010

Next review due: 09/09/2012

Comments are personal views. Any information they give has not been checked and may not be accurate.

Casualty said on 26 January 2012

My depression brought on by prescribed sleeping tablets, Benzodiazepines. It triggered psychosis or rewired the brain causing constant permanent severe head pain. The GP made it worse. More benzodiazipines were prescribed, then antidepressants - the side effects were horrific & told that this was the illness getting worse!!
Doctors do not listen & just jump in & prescribe.
The are never responsible & just state they've learnt something but won't stop.
Be careful you just may end up in a horrid chemical soup, that's worse than the induced pain or depression.

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Cedders said on 18 October 2010

The genetics of depression also reminds me of an interesting article in the Guardian this week by Ben Goldacre http://www.guardian.co.uk/commentisfree/2010/oct/09/ben-goldacre-bad-science-adhd-stigma

It seems that thinking of mental health conditions as genetically caused or biologically distinct increases the stigma and discrimination associated with condition.

Not that that has any bearing on whether there actually is a genetic component to unipolar depression, but the review does match my experience.

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Cedders said on 18 October 2010

Seems more helpful and balanced since the review of 09/09/2010. However, the "Research shows that some genes increase the risk of depression after a stressful life event" still sounds like it's based on the same 5-HTTLPR findings that weren't generally reproduced. (In other words, there might be such genes but I don't think the articles right in suggesting they have already been discovered.)

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Cedders said on 15 July 2010

I wonder if this page could say more about social causes of depression. Compared to the section on genetics, there's not much, but the evidence as I understand it is much stronger, for example linking depression to lack of a confiding partner or early bereavement. One of the the most well-known publications here is Brown and Harris's _Social Origins of Depression_ (1978).

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Cedders said on 15 July 2010

There are medical conditions that can contribute to depression as this page says. There are a few others (although of course, people with depression are often assumed to suffer from hypochondria, so maybe that's why these aren't included!). There are various possible hormonal causes, including a lot of research into cortisol. Dietary deficiencies, eg folic acid, B6, B12, are also sometimes mentioned. This is *not* to say anything one way or another about supplements or a healthy diet, merely that they are known possible causes. There's a handy list in _Mental Health Issues in Primary Care_ by Elizabeth Armstrong.

This isn't intended as advice.

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Cedders said on 15 July 2010

On the psychological side,I suggested the information about interaction between cognitive style and life events is very strong, and so could be mentioned. Cognitive style is things like whether or not negative events are seen as permanent (stable), one's own fault (internal) and wide-ranging (global). I don't have references for this to hand, but it's in standard psychology textbooks. Work on rumination is continuing.

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Cedders said on 15 July 2010

The hypotheses involving neurotransmitters are not supported by consistent evidence; they are merely hypotheses to explain how antidepressants may work.

Reserpine has an anti-serotonergic effect, and yet was the first chemical to show an anti-depressive effect in a randomised controlled trial (More information in David Healy's _The Antidepressant Era_) That's not to say that antidepressants may not work through other mechanisms.

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Cedders said on 15 July 2010

The information about the 5HTT gene is outdated. See "Interaction Between the Serotonin Transporter Gene (5-HTTLPR), Stressful Life Events, and Risk of Depression: A Meta-analysis", Risch et al. JAMA 2009;301:2462-2471.

Results: "the number of stressful life events was significantly associated with depression (OR, 1.41; 95% CI,1.25-1.57). No association was found between 5-HTTLPR genotype and depression in any of the individual studies nor in the weighted average (OR, 1.05; 95% CI, 0.98-1.13) and no interaction effect between genotype and stressful life events on depression was observed (OR, 1.01; 95% CI, 0.94-1.10 "

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Cedders said on 15 July 2010

I added a comment here on the content back in February, questioning some of the statements and also perhaps suggesting a slightly different emphasis. I asked for the content to be reviewed on 20 April, and had a proper reply on 28 May (ref: 47082ab) saying the citations I gave would be followed up, an expert clinician would review the topic before it is republished. However, I think this has still to happen, and on 12 July, my comment was removed saying "We cannot allow messages offering medical advice.... Please consider re-submitting your message without offering any 'advice' to other users."

So far as I can see, there was no medical advice in my comment. As I made it clear, I'm not medically qualified, but the information I mentioned was all from respectable sources and only vaguely touched on diagnosis and treatment. So I will re-submit in smaller pieces so I can find out which section is objectionable.

I do think it would help if more of the statements on this site were referenced.

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