Cholesterol-lowering medicines, statins - Interactions 

Interactions with other medicines 

Always read the leaflet

This is not an exhaustive list of possible interactions so it always important that you carefully read the patient information leaflet(s) that comes with your medication.

If in doubt contact your GP or pharmacist for advice.

Antibiotics

Some antibiotics, including erythromycin, clarithromycin, itraconazole, ketoconazole and miconazole, can increase your risk of muscle damage if taken with atorvastatin or simvastatin.

Speak to your doctor if you are taking atorvastatin or simvastatin and need to take one of these antibiotics. Your doctor may advise you to stop taking atorvastatin or simvastatin or take a lower dose of the statin while you are on the course of antibiotics.

The antibiotic daptomycin should also not be taken in combination with any statin.

Warfarin

Statins can enhance the effect of warfarin, which may increase your risk of bleeding.

You should have regular blood tests to monitor the effect of your statin on the warfarin, especially when starting or stopping a statin or when changing the dose of statin.

Last reviewed: 16/04/2012

Next review due: 16/04/2014

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Interactions with food and alcohol

  • There are no known interactions between statins and alcohol.
  • Avoid drinking grapefruit juice if you are taking simvastatin. Grapefruit juice reduces the breakdown by the liver of simvastatin, which raises the level of simvastatin in the blood and makes you more likely to get side effects.
  • Atorvastatin interacts with grapefruit juice if you drink large quantities, but an occasional glass is thought to be safe. It is safe to drink grapefruit juice if you are taking any of the other statins.