Uterine (uterus) cancer 

Treating uterine (uterus) cancer 

What is good care for endometrial cancer?

People with cancer should be cared for by a team of specialists who work together to provide the best treatment and care. This is called a multidisciplinary team (MDT).

The team often consists of specialist cancer surgeons (gynaecological oncologists), a medical oncologist (a chemotherapy specialist) and a specialist nurse. Other members may include a radiologist, pathologist, physiotherapist, a dietitian and an occupational therapist.

When deciding what treatment is best for you, your doctors will consider:

  • the stage of your cancer (how big it is and how far it has spread) 
  • your general health 
  • whether fertility is a matter of concern (this is rare due to the age at which endometrial cancer usually occurs)

You should feel free to discuss your treatment with your care team at any time, and to ask any questions.

The main treatments for endometrial cancer are:

  • surgery
  • radiotherapy 
  • chemotherapy

You may have one of these treatments, or a combination. This will depend mainly on the stage of your cancer. Before going to hospital to discuss your treatment options, it can be useful to write a list of questions you'd like to ask the specialist. For example, you may want to find out what the advantages and disadvantages of particular treatments are.

Stages of endometrial cancer hide

Health professionals use a staging system to describe how far endometrial cancer has advanced. These stages are:

  • Stage one: the cancer is still contained inside the uterus.
  • Stage two: the cancer has spread to the neck of the womb (the cervix).
  • Stage three: the cancer has spread outside the womb into nearby tissues in the pelvis or the lymph nodes.
  • Stage four: the cancer has spread to the bladder or bowel, or to other parts of the body (metastasis) such as the liver or lungs.

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Treatment overview  show

The main treatment for endometrial cancer is to remove the uterus (hysterectomy). This is sometimes followed by radiotherapy to try to kill any possible remaining cancer cells, depending on the stage and grade of the cancer. Chemotherapy may also be used.

Treatment for women who haven’t been through the menopause

Younger women who haven't already reached the menopause may not want to have their womb removed if they wish to have children.

In this case, under very specific circumstances, it may be possible to treat the cancer using hormone therapy.

Treating advanced cancer

Only a small minority of endometrial cancer is diagnosed at a later stage when it has spread to other parts beyond the uterus. This requires a different course of treatment, usually depending more on chemotherapy. Advanced cancer may not be curable, but the treatment aims to achieve a remission, where the cancer shrinks, making you feel normal and able to enjoy life to the full.

Even if there's no chance of a cure, surgery may be carried out to remove as much of the cancer as possible. Radiotherapy, chemotherapy or hormone therapy can reduce symptoms such as pain by shrinking the cancer or slowing its growth. This can help you feel better.

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Surgery show

Surgery for stage one endometrial cancer

If you have stage one cancer, you'll probably have a hysterectomy. This involves the removal of both ovaries and the fallopian tubes (bilateral salpingo-oophorectomy, or BSO) and the uterus (called a hysterectomy).

The surgeon may also take samples from the lymph nodes in the pelvis and abdomen, and other nearby tissue. These will be sent to the laboratory to see whether the cancer has spread.

You'll probably be ready to go home three to five days after your operation, or less if the surgery is done by keyhole techniques. But it can take many weeks to recover fully. After your operation, you'll be encouraged to start moving about as soon as possible. This is very important, and even if you have to stay in bed you'll need to keep doing regular leg movements to help your circulation and prevent blood clots. You'll be shown exercises by the nurses or physiotherapist to help prevent complications.

When you go home, you'll need to exercise gently to build up your strength and fitness. Discuss with your doctor or physiotherapist which types of exercise would be suitable for you.

Surgery for stage two or three endometrial cancer

If you have stage two or three endometrial cancer and the cancer has spread to the cervix or nearby lymph nodes in the pelvis, you may have a radical hysterectomy. This involves the additional removal of the cervix and the top of your vagina, as well as the removal of the pelvic lymph nodes. You may also need back up radiotherapy treatment after surgery.

Surgery for advanced cancer (stage four)

If you have advanced womb cancer, you may have surgery to remove as much of the cancer as possible. This is called debulking surgery. This won't cure the cancer, but it may ease some of the symptoms. Your doctor will discuss whether debulking surgery is suitable for you.

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Radiotherapy show

A course of radiotherapy will be recommended if your treatment team thinks there's a significant risk that the cancer could return in the pelvis. Radiotherapy may also be used to slow the spread of cancer when a surgical cure is not possible.

There are two types of radiotherapy that are used to treat endometrial cancer:

  • Internal radiotherapy (also known as brachytherapy), where a plastic tube is inserted inside the uterus and radiation treatment is passed down the tube into the uterus.
  • External radiotherapy, where a machine is used to deliver pulses of radiation to your pelvis.

A course of external radiotherapy is usually given to you as an outpatient, for five days a week with a break at the weekend. The treatment takes a few minutes, and the whole course of radiotherapy may last approximately four weeks, depending on the stage and position of the endometrial cancer.

Some women have internal radiotherapy (brachytherapy) as well as external radiotherapy. During brachytherapy, the device that delivers radiation is placed in your vagina and stays there until the correct dose of radiation is delivered.

There are different types of brachytherapy, involving either low, medium or high dose rates. With low dose rate methods the radiation is delivered more slowly, so the device has to stay inside you for longer. You'll have to stay in hospital while you have the treatment. Your doctor will discuss this with you.

Radiotherapy has some side effects. Skin in the treated area can become red and sore, and hair loss may occur. Radiotherapy to the pelvic area can affect the bowel, and cause sickness and diarrhoea. As your course of treatment progresses, you're likely to get very tired. Most of these side effects will go away when your treatment finishes, although around 5% of women continue with long-term treatment effects, such as diarrhoea and rectal bleeding.

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Chemotherapy show

If you have stage three or four endometrial cancer, you may be given a course of chemotherapy. Chemotherapy can be used after surgery to try to prevent the return of the cancer or, in cases of advanced cancer, to slow the spread of the cancer and relieve symptoms.

Chemotherapy is usually given as an injection into the vein (intravenously). Most often, you'll have chemotherapy as an outpatient, but sometimes you may need a short stay in hospital. Chemotherapy is usually given in cycles, with a period of treatment being followed by a period of rest to allow the body to recover.

Side effects of chemotherapy can include:

  • nausea
  • vomiting
  • hair loss
  • fatigue

The side effects should stop once the treatment has finished.

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Hormone therapy show

Some endometrial cancers are affected by the female hormone oestrogen. These cancers may respond to treatment with hormone therapy. Your doctor will discuss with you whether this is a possible treatment for your endometrial cancer.

Hormone therapy most often replaces the progesterone that would naturally occur in your body. Artificial progesterone is used and this is usually given as tablets. It's mainly used to treat advanced-stage endometrial cancers or cancer that has come back, and it can help to shrink the tumour and control any symptoms. The treatment may have some side effects, including mild nausea, mild muscle cramps and weight gain. Your doctor will discuss these with you.

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Clinical trials show

A lot of progress has been made in the treatment of endometrial cancer, and more women are living longer with fewer side effects. Some of these advances were discovered through clinical trials, in which new treatments and combinations of treatments are compared with standard treatment.

All cancer clinical trials in the UK are carefully monitored to make sure that the trial is worthwhile and safely conducted. Participants in clinical trials often do better overall than those in routine care.

If you're invited to take part in a trial, you'll be given an information sheet. If you wish to take part, you'll be asked to sign your consent. You're always free to refuse or withdraw from a clinical trial without it affecting your care.

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Last reviewed: 09/03/2011

Next review due: 09/03/2013

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