Bone marrow transplant 

Introduction 

Bone marrow transplant: Sarah's story

Sarah had leukemia and needed a bone marrow transplant. In this video she talks about her experiences.

Other types of stem cell transplantation

In the past, doctors were only able to get stem cells from bone marrow. However, it is now possible to get them from other sources.

Peripheral blood stem cell donation

A special medicine can be injected into the donor's blood, which causes the stem cells to filter out of the bone marrow and into the bloodstream. Some of the blood can then be donated to the person who needs it. This is known as a peripheral blood stem cell (PBSC) donation. The advantage is that the donor does not need a general anaesthetic (where they are put to sleep).

Cord blood donation

Stem cells can be collected from the umbilical cord of a newborn baby and stored for years in a laboratory until needed. This is known as a cord blood donation. It is important to note that stem cells are not collected from the baby, but from the blood of the cord and placenta (which are normally discarded). These cord blood stem cells are important because they do not need to be as closely matched as bone marrow or peripheral blood stem cells to ensure a successful outcome.

In October 2009, the NHS Cord Blood Bank opened its state-of-the-art storage facility at Filton, Bristol. The NHS Cord Blood Bank is the fourth largest in the world, with 14,500 donations available for therapeutic use. Deposits will be increased to 20,000 donations by 2013.

Bone marrow is a spongy material found in the hollow centres of some bones. It is important as it contains special cells known as stem cells.

Stem cells create other specialised cells that carry out important functions. Stem cells in bone marrow produce three important types of blood cells:

  • red blood cells, which carry oxygen around the body
  • white blood cells, which help fight infection
  • platelets, which help stop bleeding  

Bone marrow transplantation

Bone marrow transplantation (also known as stem cell transplantation) involves harvesting healthy stem cells to replenish the bone marrow of the patient. The new stem cells take over the production of the blood cells.

In some circumstances, it may be possible to take your own bone marrow from another part of your body (this is known as autologous transplantation). The bone marrow may be cleared of any diseased cells before being returned.

For more information, see How bone marrow transplant is performed.

Outlook

Undergoing a stem cell transplant can be an intensive and challenging experience. The medicines used to prepare the body can cause unpleasant side effects and there is a risk of complications, such as your body rejecting the new stem cells, the new stem cells attacking your body (known as graft-versus-host disease) and infection.

Many people will take up to one year to recover fully from the procedure.

  • show glossary terms

 

Last reviewed: 17/03/2010

Next review due: 17/03/2012

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