Blood donation - How it is performed 

How blood donation is performed 

Blood donation: Rudolph's story

Rudolph Isaacs has donated 41 pints of blood in 17 years. He explains why giving blood is important and how it is an easy way to help others.

Platelet donations

A platelet donation is a relatively new way of donating blood. It involves using special equipment to separate out the platelet cells from the donated blood.

Platelet cells are very useful for treating a range of conditions and situations, including:

  • leukaemia (bone marrow cancer)
  • excessive blood loss
  • people who have just received a bone marrow transplant as newly transplanted bone marrow is unable to create new blood cells, such as platelets, until 15 to 30 days after the transplant

The advantage of platelet donations is that a small amount can be used to treat several people. One donation is often enough treat up to three adults or twelve children.

The disadvantage is that donated platelets can only be stored safely for five days. This means that there is a constant demand for new donors.

Not everyone who can donate blood is able to donate platelets because you need to have a higher than average platelet rate in your blood for the donation to be successful. Your platelet rate will be tested before the donation goes ahead.

Do not be alarmed if testing shows that you have an average platelet rate and are unable to donate platelets. This is perfectly normal and is nothing to worry about.

The donation procedure is similar to regular blood donation except it takes slightly longer (about 90 minutes)

Due to the specialised equipment that is needed to separate the platelets from the blood, a donation can only be made at specialised platelets donation centres.

There are currently 24 donation centres in England, which are all located in the larger towns and cities. A list of donation centres can be found on the website of the National Blood Service.

See the National Blood Service website for more information about the platelet donation procedure or call 0300 123 23 23 to find out more. 

Blood types

Your blood type is determined by two specialised proteins called antigens. These are found on the surface of your red blood cells.

The first antigen, known as the ABO antigen, comes in four possible types:

  • A
  • B
  • AB
  • O

The second antigen, known as the Rhesus antigen, comes in two possible types:

  • Rhesus positive (usually shortened to Rhd+)
  • Rhesus negative (usually shortened to Rhd-)

Your blood type is based on a combination of both antigens. For example, if you have a combination of the AB antigen and the Rhd+ antigen, your blood type would be AB+.

Someone who has a blood transfusion must receive blood from a donor with the same blood type, otherwise their immune system (the body’s natural defence against infection) may attack the donated blood. This could lead to potentially life-threatening conditions.

Blood donations are always welcome from people with common blood groups, such as O+, as there is a high demand for this blood type. Blood donations are obviously also welcome from people with rarer blood groups, such as AB-, as the supply of this type of blood is limited.

Find your nearest centre

Blood donor sessions take place all over the country throughout the year. The National Blood Service holds over 23,000 blood donation sessions a year, many of which are held in mobile donation centres.

To find your nearest blood donation centre, call the National Blood Service free on 0300 123 23 23. You can make an appointment for a date and time that are convenient for you.

Alternatively, visit the National Blood Service website, where you can search for your nearest centre. You can also book an appointment to give blood using the online form.

Most people can donate blood every 16 weeks (four months).

If you have never given blood before, you can register as a blood donor on the National Blood Service website.

Before donating blood

Before donating blood, make sure that you eat and drink at least a few hours before your appointment. This will help stop you feeling faint or dizzy after you have given blood. Do not drink alcohol before you give blood.

Important information

When you arrive at the donation centre to donate blood, you will be given some information to read. It is very important that you read this information because it will explain the procedure, and will help ensure that you are suitable to give blood. See Blood donation - who can use it? for information about who can and cannot give blood.

After reading the information, you will be asked to fill in a confidential donor health check form. You will be asked to answer a number of questions about your health and lifestyle. It is very important that you answer the questions honestly and accurately to ensure that the blood you donate is safe to use.

If you are donating blood for the first time, you may also have a confidential discussion with a nurse.

Anaemia check

Once you have completed your donor health check form, a very small blood sample will be taken from your finger tip. Only a droplet of blood is needed. This will be tested to determine how much haemoglobin it contains.

Haemoglobin is a substance that is present in red blood cells. It helps carry oxygen around the body. Anaemia is a condition that occurs when you do not have enough red blood cells, or when the blood cells do not contain enough haemoglobin. Symptoms of anaemia can include:

  • tiredness
  • lethargy
  • shortness of breath
  • palpitations (irregular heartbeat)

If your haemoglobin level is very low, giving blood could make you anaemic. If this is the case, you may need to visit your GP before you can give blood.

See the Health A-Z topic about Anaemia - iron deficiency for more information about this condition.

Donating blood

Once you have passed all of the necessary health checks, you will be able to donate blood. It usually takes 10 to 15 minutes for a sample of your blood to be collected.

The donation procedure will usually involve a cuff being placed around your arm. The cuff will be inflated to help make it easier for the healthcare professional to access the veins in your arm.

A sterile needle will be inserted into a vein in your arm and will be held in place with tape.

You will barely feel the needle. Once the needle is in place, a syringe will be used to collect a sample of your blood.

The needle will be used only once and will be discarded after your donation.

During most blood donations, approximately 470ml (just under one pint) of blood will be taken. This amount is only 10-12% of an adult's blood supply, and your body will be able to replace it very quickly.

As long as you are well hydrated after your blood donation, your body will make up the fluid part of the blood within a few hours. It will take just a few weeks for your body to fully replace all of the blood cells.

Virtual session

You can find out what happens at a blood donor session using the virtual session provided by National Blood Service. This takes you through a blood donor session step-by-step.

After donating

After donating blood, you will need to rest for a short while. You will be offered refreshments to stop you feeling faint or dizzy. The whole process of donating blood should not take longer than an hour.

If you smoke, it is recommended that you avoid smoking for two hours after giving blood because smoking could make you feel faint and dizzy.

Donating blood is very safe, although you may experience some mild after effects such as:

  • bruising at the site where the blood was taken (which affects around 1 in 4 people)
  • a sore arm (which affects around 1 in 10 people)
  • dizziness and fainting (which affects around 1 in 15 people)

More serious after effects that require medical treatment are very rare, occurring in less than 1 in every 3,500 cases.

If you become unwell within two weeks of your donation, call the National Blood Service on 0300 123 23 23. Also call this number if you feel persistently faint following your donation.

If you are concerned about your symptoms, you can call NHS Direct on 0845 46 47 for further advice.

  • show glossary terms
Blood
Blood supplies oxygen to the body and removes carbon dioxide. It is pumped around the body by the heart.
Donor
A donor is a person (living or dead) who donates blood, an organ or other body parts to another person in need.
Platelets
Platelets are cells in the blood that control bleeding by plugging the broken blood vessel and helping the blood to clot.
Red cells
Red blood cells transport oxygen around the body and remove carbon dioxide.
Vein
Veins are blood vessels that carry blood from the rest of the body back to the heart.

Last reviewed: 10/05/2010

Next review due: 10/05/2012