Behçet's disease 


Painful mouth ulcers are a symptom of Behçet's disease 

Behçet's disease is a rare and poorly understood condition in which blood vessels and tissues may become inflamed (swollen).

It is sometimes referred to as an autoinflammatory disease, as certain cells of the immune system may begin this inflammation when triggered.

It is also known as Behçet's syndrome.

Signs and symptoms

The inflammation associated with Behçet's disease can affect blood vessels located within tissues throughout the body. It can therefore cause a wide range of symptoms.

Common symptoms include:

In severe causes, there is also a risk of serious and potentially life-threatening problems, such as permanent vision loss and strokes.

Read more about the symptoms of Behçet's disease.

Seeking medical advice

You should see your GP if you have a collection of persistent symptoms of Behçet's disease.

Confirming a diagnosis of Behçet's disease can be difficult because the symptoms are wide ranging and are shared with a number of other conditions.

A diagnosis will usually need to be made by a specialist based on your symptoms and by ruling out other conditions.

Read more about diagnosing Behçet's disease

What causes Behçet's disease?

The cause of Behçet's disease is unknown, although most experts believe it is an autoinflammatory condition.

An autoinflammatory condition is where the immune system – the body's natural defence against infection and illness – mistakenly attacks healthy tissue.

In cases of Behçet's disease, it is thought the immune system mistakenly attacks the blood vessels.

It's not clear what triggers this problem with the immune system, but it is very likely that both genes and environmental factors play a role.

Read more about the causes of Behçet's disease.

Who is affected?

Behçet's disease tends to be more common in the Far East, the Middle East and Mediterranean countries such as Turkey, Iran and Israel.

It is much rarer in the UK, affecting an estimated 1,000 people in total.

People of Mediterranean, Middle Eastern and Asian origin are thought to be most at risk of developing the condition, although it can affect all ethnic groups.

The symptoms of Behçet's disease can begin at any age, although they usually first appear when a person is between 20 and 30 years of age, and less commonly start after the age of 50.

How Behçet's disease is treated

There is no cure for Behçet's disease, but it is often possible to control the symptoms with medicines that reduce the inflammation in the affected parts of the body.

These medications include:

  • corticosteroids – powerful anti-inflammatory medications
  • immunosuppressants – medications that reduce the activity of the immune system
  • biological therapies – medications that target the biological processes involved in the process of inflammation

Your healthcare team will create a specific treatment plan for you depending on your symptoms.

Read more about treating Behçet's disease.


Behçet's disease is highly unpredictable. Most people with the condition will experience episodes where their symptoms are severe (flare-ups or relapses), followed by periods where the symptoms disappear (remission).

As yet, no triggers have been identified that cause a flare-up of symptoms.

Over time, some of the symptoms can settle down and become less troublesome, although they may never resolve completely.

In the most serious cases, inflammation of the eyes can lead to vision loss. However, modern treatments can help reduce this risk when started early.

Inflammation of the nervous system, veins and arteries or heart can be life threatening, but because of the standard of care in UK, deaths from Behçet's disease are rare.

Page last reviewed: 01/09/2014

Next review due: 01/09/2016


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The 2 comments posted are personal views. Any information they give has not been checked and may not be accurate.

VALLY64 said on 08 May 2012

I was diagnosed with Behçet’s Disease/Syndrome 8mths ago in Autumn 2011. I also suffer from Parvovirus Arthritis & Reynaulds so I have a number of overlapping symptoms.

With Behçet’s I have joint pain at all times but in varying degrees of severity; regular (almost permanent) crops of mouth ulcers which extend to the back of my throat as well as my gums, tongue and inner cheeks. I suffer headaches, nausea & dizziness and I have patches of painful vasculitis on my thighs.

I get very tired easily despite being energetic and hardworking. I manage to work part time as a Registered Nurse in a busy I.T.U. I split my duties so that I can rest the day after a shift as my joints get stiff & painful.

I'm under the care of a Consultant Rheumatologist and presently on Naproxen 250mgs, 3 times day.
Omeprazole 20mg to protect my stomach.
I take Stemetil tabs when I have bouts of nausea and dizziness. And I take regular Paracetamol containing Caffeine.

I suffer from a wide variety of transient symptoms but as I'm 48 and in the Peri-menopausal stage I'm not sure what I can attribute to the conditions I suffer from.

I find it helpful to keep a diary of symptoms, flares: duration, dates etc. This is a great help when visiting the consultant as often things are forgotten in time, it also helps him gauge how the Behcets is progressing or being managed.

Eat a healthy diet and exercise regularly, learn what foods affect you, I'm better off wheat but I don't forbid myself a treat. Stay positive and live your life!
I hope this helps a little.

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sooty50 said on 23 April 2011

i started with bechets at the age 27yr i am now 50yr i have all the symptoms and was under very good doctor at my local hospital i have had all the drugs for this desease but nothing really work just make me more poorly i was in hospital cripled with this illness also had the ulcers mouth and virgina i am still in pain now but every joint i have been on chloroquine 250mg now for 15yrs which as kept it under controll but now i feel that its not working as good i am now get the headaces and sickness all the time but i have got on with my life when i have been able grown hard to the pain had to learn to live with it as i had 2 boys who i have bring up on my own this desease is so horrible and when i have flare ups thers no pain like it i have learnt that you have to keep active as you stiffen up which makes you tierd all time i felt like old women at 27yrs old i sit down when i got up i cripled untill i got my body going my tongue as been eaten away with the ulcers and virgina also i just wanted to die at that time of my flare up i find diet helps stay of acid drinks food otherwise i get burning feeling in my joints i now have sore ankles wrists fingers hips shoulders neck and just tierd all time this is my experience of bechets

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